Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Ali Jahanian, Najafabadi"'
Autor:
Saghi Jani Kargar Moghaddam, Amaneh Mohammadi Roushandeh, Masoud Hamidi, Shadman Nemati, Ali Jahanian-Najafabadi, Mehryar Habibi Roudkenar
Publikováno v:
Iranian Journal of Medical Sciences, Vol 48, Iss 3, Pp 268-276 (2023)
Background: Lipocalin-2 (LCN2) deregulation has been reported in several types of cancer and is implicated in the proliferation, migration, angiogenesis, and progression of tumors. However, its aberrant expression has been rarely studied in nasophary
Externí odkaz:
https://doaj.org/article/6dc42e3f77534b28993637ee7c2b0da0
Autor:
Zahra Pourmohammadi-Bejarpasi, Reza Sabzevari, Amaneh Mohammadi Roushandeh, Ammar Ebrahimi, Mohammadreza Mobayen, Ali Jahanian-Najafabadi, Abbas Darjani, Mehryar Habibi Roudkenar
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 12, Iss 3, Pp 550-560 (2022)
Purpose: Currently, several disorders including burns, trauma, excisional and diabetic wounds,and bedsores threaten the human health. Application of mesenchymal stem cells (MSCs) isrecommended for treatment of skin disorders. However, because of oxid
Externí odkaz:
https://doaj.org/article/2e4835a3f07c4966a359da0ff5b1f68c
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 3, Pp 218-225 (2020)
Background and purpose: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine with a wide range of therapeutic applications although expression of GM-CSF in Escherichia coli (E. coli) usually leads to formation of insoluble aggregat
Externí odkaz:
https://doaj.org/article/a32cb1ab45c5431dbaf778f906bb215a
In silico design of two novel fusion proteins, p28-IL-24 and p28-M4, targeted to breast cancer cells
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 2, Pp 200-208 (2020)
Background and purpose: An anticancer peptide P28, has shown to be cytolethal on various cancer cells including breast cancer. Moreover, p28 can be alsoused as a targeting moiety in the structure of fusion proteins. IL-24 (or its truncated form, M4)
Externí odkaz:
https://doaj.org/article/9b14d2e3be224c0488c761df743f48dc
Autor:
Niloufar Mohammadian, Hossein Mohammadian, Fatemeh Moazen, Mohammad Hosein Pakdel, Ali Jahanian-Najafabadi, Hamid Mir Mohammad Sadeghi
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 4, Pp 331-339 (2020)
Background and purpose: Tobacco etch virus (TEV) protease, a 27 KDa protein, consists of the catalytic domain of nuclear inclusion a (NIa) protein produced by Tobacco etch virus. Because of its unique sequence, TEV protease is used for purging fusion
Externí odkaz:
https://doaj.org/article/fa181b937e5d47809bab552659455a0d
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Cancer is one of the prominent causes of death worldwide. Despite the existence of various modalities for cancer treatment, many types of cancer remain uncured or develop resistance to therapeutic strategies. Furthermore, almost all chemotherapeutics
Externí odkaz:
https://doaj.org/article/1bcc58f70af4452abfde4249376ee483
Autor:
Jaleh Varshosaz, Erfaneh Ghassami, Abdollah Noorbakhsh, Mohsen Minaiyan, Ali Jahanian‐Najafabadi
Publikováno v:
IET Nanobiotechnology, Vol 13, Iss 8, Pp 829-833 (2019)
Human epidermal growth factor receptor 2 (HER‐2) is overexpressed in 20–30% of human breast cancers, associated with poor prognosis and tumour aggression. The aim of this study was the production of trastuzumab‐targeted Ecoflex nanoparticles (N
Externí odkaz:
https://doaj.org/article/397b67cdeccc42f7aa8207b2c9116ab4
Publikováno v:
Research in Pharmaceutical Sciences, Vol 14, Iss 4, Pp 320-328 (2019)
Interleukin (IL) 24 is a pro-inflammatory and tumor suppressor cytokine capable of inducing selective apoptosis in various cancer cells. BR2, on the other hand, is an anti-microbial peptide with selective penetrability to the cancer cells. In this st
Externí odkaz:
https://doaj.org/article/6f1461e11e99433e82e06edb19a1b34d
Autor:
Tahereh Sadeghian-Rizi, Azade Ebrahimi, Fatemeh Moazzen, Hesam Yousefian, Ali Jahanian-Najafabadi
Publikováno v:
Research in Pharmaceutical Sciences, Vol 14, Iss 5, Pp 400-407 (2019)
Overexpression of recombinant proteins in Escherichia coli results in inclusion body formation, and consequently decreased production yield and increased production cost. Co-expression of chaperon systems accompanied by recombinant protein is a gener
Externí odkaz:
https://doaj.org/article/8442b7c18c5748c3b504a4f95a6f751a
Publikováno v:
Research in Pharmaceutical Sciences, Vol 14, Iss 4, Pp 369-377 (2019)
Klotho is considered as an anti-aging factor inducing insulin resistance and involved in type 2 diabetes. However, mechanisms by which klotho induces insulin resistance remain to be understood. Thus, in this study, we aimed to evaluate possible inter
Externí odkaz:
https://doaj.org/article/0969f7f70577449cba1249fefce5f368