Výsledky vyhledávání - "Ali H Ellebedy"

Akademický článek

Assessment of antibodies in the upper and lower human respiratory tract at steady state and after respiratory viral infection

Autor: Marios Koutsakos, Jackson S Turner, M Cristina Vazquez Guillamet, Daniel Reynolds, Tingting Lei, Derek E Byers, Ali H Ellebedy, Philip A Mudd

Publikováno v: Clinical & Translational Immunology, Vol 12, Iss 8, Pp n/a-n/a (2023)

Abstract Objectives There is an increasing appreciation for the need to study mucosal antibody responses in humans. Our aim was to determine the utility of different types of samples from the human respiratory tract, specifically nasopharyngeal (NP)

Externí odkaz: https://doaj.org/article/0889cf52f04a40f68c7ee341b9a9fdcb

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Akademický článek

Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

Autor: Kenneth B Hoehn, Jackson S Turner, Frederick I Miller, Ruoyi Jiang, Oliver G Pybus, Ali H Ellebedy, Steven H Kleinstein

Publikováno v: eLife, Vol 10 (2021)

The poor efficacy of seasonal influenza virus vaccines is often attributed to pre-existing immunity interfering with the persistence and maturation of vaccine-induced B cell responses. We previously showed that a subset of vaccine-induced B cell line

Externí odkaz: https://doaj.org/article/a02d4d2d2cdd46088337aeb5a30242a5

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Akademický článek

Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

Autor: Daniel Stadlbauer, Meagan McMahon, Hannah L. Turner, Xueyong Zhu, Hongquan Wan, Juan Manuel Carreño, George O’Dell, Shirin Strohmeier, Zain Khalil, Marta Luksza, Harm van Bakel, Viviana Simon, Ali H. Ellebedy, Ian A. Wilson, Andrew B. Ward, Florian Krammer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)

Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glyco

Externí odkaz: https://doaj.org/article/ea11854011e8459a82e13f846026455f

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Akademický článek

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Autor: Guha Asthagiri Arunkumar, Disha Bhavsar, Tiehai Li, Shirin Strohmeier, Veronika Chromikova, Fatima Amanat, Mehman Bunyatov, Patrick C. Wilson, Ali H. Ellebedy, Geert-Jan Boons, Viviana Simon, Robert P. de Vries, Florian Krammer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

The recently identified Wuhan spiny eel influenza virus (WSEIV) sequence is more closely related to influenza B than A viruses. Here, the authors functionally characterize the putative surface glycoproteins of WSEIV and show that its NA-like protein

Externí odkaz: https://doaj.org/article/7d019ab5c90341b1b42cb0b05de64f8d

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Akademický článek

Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain

Autor: Clara G. Altomare, Daniel C. Adelsberg, Juan Manuel Carreno, Iden A. Sapse, Fatima Amanat, Ali H. Ellebedy, Viviana Simon, Florian Krammer, Goran Bajic

Publikováno v: mBio, Vol 13, Iss 3 (2022)

ABSTRACT Structural characterization of infection- and vaccination-elicited antibodies in complex with antigen provides insight into the evolutionary arms race between the host and the pathogen and informs rational vaccine immunogen design. We isolat

Externí odkaz: https://doaj.org/article/7a2d1df034874f1281491d42db5fb6c5

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Akademický článek

PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2

Publikováno v: mSphere, Vol 7, Iss 3 (2022)

ABSTRACT To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated

Externí odkaz: https://doaj.org/article/b59ae6f5c06f419881a4ea9667b385f3

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Akademický článek

Immune checkpoint modulation enhances HIV-1 antibody induction

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Elucidation of broadly neutralizing antibodies (bnAb) is a goal in HIV vaccine development. Here, Bradley et al. show that administration of CTLA-4 blocking antibody with vaccine antigens increases HIV-1 envelope antibody responses in macaques and a

Externí odkaz: https://doaj.org/article/2846a0ffd9114ffb86364a75259018f1

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Akademický článek

Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

Publikováno v: mBio, Vol 12, Iss 5 (2021)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-

Externí odkaz: https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e

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