Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Ali Ghuma"'
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Akademický článek
An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage.
Autor: Rajaie Namas, Ali Ghuma, Andres Torres, Patricio Polanco, Hernando Gomez, Derek Barclay, Lisa Gordon, Sven Zenker, Hyung Kook Kim, Linda Hermus, Ruben Zamora, Matthew R Rosengart, Gilles Clermont, Andrew Peitzman, Timothy R Billiar, Juan Ochoa, Michael R Pinsky, Juan Carlos Puyana, Yoram Vodovotz
Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8406 (2009)
BACKGROUND:Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental. METHODOLOGY/PRINCIPAL FINDINGS:Paradoxically, plasma levels of the early inflammatory cytokine TNF-alpha (but not IL-
Externí odkaz: https://doaj.org/article/c536708d11474bfc8381dae7a923e8be
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2
Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients
Autor: Ruben Zamora, Akram Zaaqoq, Timothy R. Billiar, Khalid Almahmoud, Yoram Vodovotz, Rami A. Namas, Othman Abdul-Malak, Jason L. Sperry, Ali Ghuma, Xiao-Guang Zhu, Qi Mi, Rajaie Namas
Publikováno v: Journal of Critical Care. 36:146-153
Purpose We hypothesized that early inflammation can drive, or impact, later multiple organ dysfunction syndrome (MODS), that patient-specific principal component analysis (PCA) of circulating inflammatory mediators could reveal conserved dynamic resp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571640695475c07e321c10f849ddb402
https://doi.org/10.1016/j.jcrc.2016.07.002
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3
The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects
Autor: Ruben Zamora, L Hermus, Timothy R. Billiar, Yoram Vodovotz, Ali Ghuma, Rajaie Namas, David O. Okonkwo
Publikováno v: Libyan Journal of Medicine; Vol 4, No 3 (2009); 97-103
Libyan Journal of Medicine, Vol 4, Iss 3, Pp 136-148 (2009)
The Libyan Journal of Medicine
Libyan Journal of Medicine; Vol 4, No 3 (2009)
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may result in death. Inflammation describes a coordinated series of molecular, cellular, tissue, organ, and systemic responses that drive the pathology of various d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1500fda0787ae938fcd37f8543baeb3
https://doi.org/10.4176/090325
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4
Trauma in silico: Individual-specific mathematical models and virtual clinical populations
Autor: David L. Brown, Gregory M. Constantine, Timothy R. Billiar, Derek Barclay, Andrew Abboud, Ruben Zamora, Rami A. Namas, Akram Zaaqoq, Yoram Vodovotz, Khalid Almahmoud, Joydeep Sarkar, Ali Ghuma, S. Chang, Jinling Yin, Gary F. Nieman
Publikováno v: Science Translational Medicine. 7
Trauma-induced critical illness is driven by acute inflammation, and elevated systemic interleukin-6 (IL-6) after trauma is a biomarker of adverse outcomes. We constructed a multicompartment, ordinary differential equation model that represents a vir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5485aee490c4a817948a3ecb313028
https://doi.org/10.1126/scitranslmed.aaa3636
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5
An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage
Autor: Juan Carlos Puyana, Derek Barclay, Andres Torres, Michael R. Pinsky, Gilles Clermont, Rajaie Namas, Patricio M. Polanco, Juan B. Ochoa, Lisa Gordon, Hernando Gomez, Hyung Kook Kim, Linda Hermus, Yoram Vodovotz, Sven Zenker, Andrew B. Peitzman, Matthew R. Rosengart, Ali Ghuma, Timothy R. Billiar, Ruben Zamora
Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8406 (2009)
PLoS ONE
BACKGROUND:Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental. METHODOLOGY/PRINCIPAL FINDINGS:Paradoxically, plasma levels of the early inflammatory cytokine TNF-alpha (but not IL-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5c9ad68a565e146c4a3e96933f31c0
http://europepmc.org/articles/PMC2794373?pdf=render
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8
Data-driven segregation of trauma patients using principal component analysis yields novel, patient-specific insights into acute inflammation
Autor: Yoram Vodovotz, Juan B. Ochoa, Ali Ghuma, Ruben Zamora, Rajaie Namas, Timothy R. Billiar, Cordelia Giraldo, Qi Mi
Publikováno v: Journal of Critical Care. 26:e2
Objectives: The human inflammatory response to trauma is a multidimensional, complex process that manifests in patient-topatient variability. We have attempted to elucidate aspects of this response using mathematical approaches, with the goal of impr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4335bc4e13b40c04d48886d1bb24b9ff
https://doi.org/10.1016/j.jcrc.2010.12.020
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9
Principal component analysis delineates both subgroup- and patient-specific insights into acute inflammation in trauma patients
Autor: Ruben Zamora, Yoram Vodovotz, Cordelia Ziraldo, Timothy R. Billiar, Rajaie Namas, Qi Mi, Juan B. Ochoa, Ali Ghuma
Publikováno v: Journal of Critical Care. 24:e24
Results: Mortality was 14% (76 patients). Increases in pressures were associated with small but statistically significant decreases in HR complexity; associations between RR and HR complexity were not significant (Table 1). Decreased HR complexity re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96e5d1a0e6c3d127fb88deddf11a68d9
https://doi.org/10.1016/j.jcrc.2009.06.026
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