Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ali Filali"'
Autor:
Tomas Raul Wiche Salinas, Yuwei Zhang, Annie Gosselin, Natalia Fonseca Rosario, Mohamed El-Far, Ali Filali-Mouhim, Jean-Pierre Routy, Carl Chartrand-Lefebvre, Alan L. Landay, Madeleine Durand, Cécile L. Tremblay, Petronela Ancuta
Publikováno v:
Cells, Vol 13, Iss 2, p 157 (2024)
Cardiovascular disease (CVD) remains an important comorbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed in the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Sco
Externí odkaz:
https://doaj.org/article/6e3d5b0e9ac945fea97b1abf8a1ce930
Autor:
Saud Al-Romaih, Oumkaltoum Harati, Leandra Endam Mfuna, Ali Filali-Mouhim, Audrey Pelletier, Axel Renteria Flores, Martin Desrosiers
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
JustificationWe have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live Lactococcus lactis W136, a probiotic bacterium, improves sinus-specific symptoms, SNOT-22, and muco
Externí odkaz:
https://doaj.org/article/453be0c95f494a358a178ff7133cd202
Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects.
Autor:
Sabrina Mazouz, Eduardo Salinas, Nathalie Bédard, Ali Filali, Omar Khedr, Leo Swadling, Mohamed S Abdel-Hakeem, Asiyah Siddique, Eleanor Barnes, Julie Bruneau, Arash Grakoui, Naglaa H Shoukry
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010968 (2022)
Successive episodes of hepatitis C virus (HCV) infection represent a unique natural rechallenge experiment to define correlates of long-term protective immunity and inform vaccine development. We applied a systems immunology approach to characterize
Externí odkaz:
https://doaj.org/article/b2d2784ae87745beaff1b98d4364a008
Autor:
Mohamed El-Far, Madeleine Durand, Isabelle Turcotte, Etienne Larouche-Anctil, Mohamed Sylla, Sarah Zaidan, Carl Chartrand-Lefebvre, Rémi Bunet, Hardik Ramani, Manel Sadouni, Irina Boldeanu, Annie Chamberland, Sylvie Lesage, Jean-Guy Baril, Benoit Trottier, Réjean Thomas, Emmanuel Gonzalez, Ali Filali-Mouhim, Jean-Philippe Goulet, Jeffrey A. Martinson, Seble Kassaye, Roksana Karim, Jorge R. Kizer, Audrey L. French, Stephen J. Gange, Petronela Ancuta, Jean-Pierre Routy, David B. Hanna, Robert C. Kaplan, Nicolas Chomont, Alan L. Landay, Cécile L. Tremblay
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) are still at higher risk for cardiovascular diseases (CVDs) that are mediated by chronic inflammation. Identification of novel inflammatory mediators with the inherent
Externí odkaz:
https://doaj.org/article/6cd3db3e427a4bd79f37a17e37cb3983
Autor:
Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sékaly
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepat
Externí odkaz:
https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde
Autor:
Jie Liu, Elias K Haddad, Joshua Marceau, Kaitlyn M Morabito, Srinivas S Rao, Ali Filali-Mouhim, Rafick-Pierre Sekaly, Barney S Graham
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005486 (2016)
CD8 T cells are involved in pathogen clearance and infection-induced pathology in respiratory syncytial virus (RSV) infection. Studying bulk responses masks the contribution of individual CD8 T cell subsets to protective immunity and immunopathology.
Externí odkaz:
https://doaj.org/article/5d578798acce4e7981800e8689019bd5
Autor:
Vanessa A Evans, Nitasha Kumar, Ali Filali, Francesco A Procopio, Oleg Yegorov, Jean-Philippe Goulet, Suha Saleh, Elias K Haddad, Candida da Fonseca Pereira, Paula C Ellenberg, Rafick-Pierre Sekaly, Paul U Cameron, Sharon R Lewin
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003799 (2013)
Latently infected resting CD4(+) T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and reversed is critical to identifying novel strategies to eliminate latently infected cells. We demonstrate here that co-
Externí odkaz:
https://doaj.org/article/f83812028fa3419e87c01200d2ce81e5
CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.
Autor:
Yoav Peretz, Zhong He, Yu Shi, Bader Yassine-Diab, Jean-Philippe Goulet, Rebeka Bordi, Ali Filali-Mouhim, Jean-Baptiste Loubert, Mohamed El-Far, Franck P Dupuy, Mohamed Rachid Boulassel, Cécile Tremblay, Jean-Pierre Routy, Nicole Bernard, Robert Balderas, Elias K Haddad, Rafick-Pierre Sékaly
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002840 (2012)
Chronic viral infections lead to persistent CD8 T cell activation and functional exhaustion. Expression of programmed cell death-1 (PD-1) has been associated to CD8 T cell dysfunction in HIV infection. Herein we report that another negative regulator
Externí odkaz:
https://doaj.org/article/c5e1765020184b05ba671f1bc2c4d3cf
Autor:
Marc Charabati, Stephanie Zandee, Antoine P Fournier, Olivier Tastet, Karine Thai, Roxaneh Zaminpeyma, Marc-André Lécuyer, Lyne Bourbonnière, Sandra Larouche, Wendy Klement, Camille Grasmuck, Fiona Tea, Bettina Zierfuss, Ali Filali-Mouhim, Robert Moumdjian, Alain Bouthillier, Romain Cayrol, Evelyn Peelen, Nathalie Arbour, Catherine Larochelle, Alexandre Prat
Publikováno v:
Brain. 146:1483-1495
The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with the infil
Autor:
Alexis Vivoli, Julien Ghislain, Ali Filali-Mouhim, Zuraya Elisa Angeles, Anne-Laure Castell, Robert Sladek, Vincent Poitout
Publikováno v:
Diabetes. 72:45-58
The functional mass of insulin-secreting pancreatic β-cells expands to maintain glucose homeostasis in the face of nutrient excess, in part via replication of existing β-cells. Type 2 diabetes appears when these compensatory mechanisms fail. Nutrie