Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ali C.M. Johnson"'
Autor:
Richard A. Zager, Ali C.M. Johnson
Publikováno v:
Translational Research. 237:53-62
Cardiorenal syndrome I (CRS-1) denotes a state in which acute kidney injury occurs in the setting of acute heart failure (AHF). Isoproterenol (Iso) administration is widly used as an AHF model by transiently inducing extreme tachycardia, hypotension,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25a9bab996b69602b432f239c25b256
https://doi.org/10.1016/j.trsl.2021.06.005
https://doi.org/10.1016/j.trsl.2021.06.005
Publikováno v:
Clin J Am Soc Nephrol
BACKGROUND AND OBJECTIVES: Oxidative stress is a hallmark and mediator of CKD. Diminished antioxidant defenses are thought to be partly responsible. However, there is currently no way to prospectively assess antioxidant defenses in humans. Tin protop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abe7b9ecda4a2345aa8c8b87edfaa5c
https://doi.org/10.2215/cjn.15951219
https://doi.org/10.2215/cjn.15951219
Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway
Autor:
Ali C.M. Johnson, Richard A. Zager
Publikováno v:
American Journal of Physiology-Renal Physiology. 316:F674-F681
The cyclin kinase inhibitor p21 is acutely upregulated during acute kidney injury (AKI) and exerts cytoprotective effects. A proposed mechanism is oxidant stress-induced activation of p53, the dominant p21 transcription factor. Glycerol-induced rhabd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323f7fde0cc8513920f24fdefffedb38
https://doi.org/10.1152/ajprenal.00571.2018
https://doi.org/10.1152/ajprenal.00571.2018
Autor:
Ali C.M. Johnson, Richard A. Zager
Publikováno v:
Physiological Reports, Vol 8, Iss 18, Pp n/a-n/a (2020)
Physiological Reports
Physiological Reports
Background Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO‐1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal‐ and extra‐renal tissue injuries. This effect is mediated, in part, via SnPP‐induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b4ac18ebbdd65ba8b8c22e310a314c
https://doaj.org/article/d66a6191b3c947279fbd18419851a1db
https://doaj.org/article/d66a6191b3c947279fbd18419851a1db
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 36(3)
Background Iron sucrose (FeS) administration induces a state of renal preconditioning, protecting against selected forms of acute kidney injury (AKI). Recent evidence suggests that recombinant hepcidin also mitigates acute renal damage. Hence the goa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03d38af04b2b4cfc756eb834bfe291
https://pubmed.ncbi.nlm.nih.gov/33547792
https://pubmed.ncbi.nlm.nih.gov/33547792
Autor:
Richard A. Zager, Ali C.M. Johnson
Publikováno v:
Nephrology Dialysis Transplantation. 33:1927-1941
Background P21, a cyclin kinase inhibitor, is upregulated by renal 'ischemic preconditioning' (IPC), and induces a 'cytoresistant' state. However, P21-induced cell cycle inhibition can also contribute to cellular senescence, a potential adverse renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25047433d05f912a2907df4b3a36f8e8
https://doi.org/10.1093/ndt/gfy029
https://doi.org/10.1093/ndt/gfy029
Autor:
Ali C.M. Johnson, Richard A. Zager, Henrick Rasmussen, Guillem Alvaro F, Ted Gooley, Jeff Keyser, Bhupinder Singh
Publikováno v:
American journal of physiology. Renal physiology. 317(6)
Experimental data suggest that iron sucrose (FeS) injection, used either alone or in combination with other prooxidants, can induce “renal preconditioning,” in part by upregulating cytoprotective ferritin levels. However, the rapidity, degree, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840b8460d90fc774443e20deb6a53d34
https://pubmed.ncbi.nlm.nih.gov/31608670
https://pubmed.ncbi.nlm.nih.gov/31608670
Autor:
Roya Sharifian, Richard A. Zager, Oleg Denisenko, Ali C.M. Johnson, Sina A. Gharib, Karol Bomsztyk, Daryl M. Okamura
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states. Although changes in gene expression patterns have recently been elucidated for the transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb3c107ddb0e22e3d9386ec4c2f9e70
https://doi.org/10.1038/s41598-018-35943-x
https://doi.org/10.1038/s41598-018-35943-x
Publikováno v:
American Journal of Physiology-Renal Physiology. 311:F640-F651
α1-Microglobulin (A1M) is a low-molecular-weight heme-binding antioxidant protein that is readily filtered by the glomerulus and reabsorbed by proximal tubules. Given these properties, recombinant A1M (rA1M) has been proposed as a renal antioxidant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b22c76e2c3182571cb34ad6a709e4bb
https://doi.org/10.1152/ajprenal.00264.2016
https://doi.org/10.1152/ajprenal.00264.2016
Publikováno v:
Kidney International. 90:67-76
Tissue preconditioning, whereby various short term stressors initiate organ resistance to subsequent injury, is well recognized. However, clinical preconditioning of the kidney for protection against acute kidney injury (AKI) has not been established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee8f2b681dce96d1538a54c49eca6f8
https://doi.org/10.1016/j.kint.2016.01.022
https://doi.org/10.1016/j.kint.2016.01.022