Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression

Autor: Helena Lund-Palau, Claudia Ivette Juarez-Molina, Cuixiang Meng, Anushka Bhargava, Aikaterini Pilou, Kiran Aziz, Nora Clarke, Naoko Atsumi, Ali Ashek, Michael R. Wilson, Masao Takata, Simon Padley, Deborah R. Gill, Stephen C. Hyde, Cliff Morgan, Eric W.F.W. Alton, Uta Griesenbach

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 382-391 (2022)

We developed a novel lentiviral vector, pseudotyped with the F and HN proteins from Sendai virus (rSIV.F/HN), that produces long-lasting, high-efficiency transduction of the respiratory epithelium. Here we addressed whether this platform technology c

Externí odkaz: https://doaj.org/article/4c2433997a7f402b8741006400d6273c

Application of [18F]FLT-PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers

Autor: Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton V. Noordegraaf, Jurjan Aman, Hans Harms, Frances S. de Man, Marc C. Huisman, Lan Zhao, Harm J. Bogaard

Publikováno v: Pulmonary Circulation, Vol 11 (2021)

Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3′-deoxy-3′-[18F]-fluorot

Externí odkaz: https://doaj.org/article/12b7dfe777ea4a989667e82718226482

Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.

Autor: Ali Ashek, Robert I Menzies, Linda J Mullins, Christopher O C Bellamy, Anthony J Harmar, Christopher J Kenyon, Peter W Flatman, John J Mullins, Matthew A Bailey

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e36311 (2012)

Transgenic rats with inducible expression of the mouse Ren2 gene were used to elucidate mechanisms leading to the development of hypertension and renal injury. Ren2 transgene activation was induced by administration of a naturally occurring aryl hydr

Externí odkaz: https://doaj.org/article/54047f7466664a23a9d55dee0886b846

SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension

Autor: Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, Olin D. Liang, Ali Ashek, Olivier Dubois, Lin Zhao, Farah Sabrin, Inês Cebola, Jorge Ferrer, Nicholas W. Morrell, James R. Klinger, Martin R. Wilkins, Lan Zhao, Christopher J. Rhodes

Publikováno v: Circulation, 147(21), 1606-1621. Lippincott Williams and Wilkins
Walters, R, Vasilaki, E, Aman, J, Chen, C-N, Wu, Y, Liang, O D, Ashek, A, Dubois, O, Zhao, L, Sabrin, F, Cebola, I, Ferrer, J, Morrell, N W, Klinger, J R, Wilkins, M R, Zhao, L & Rhodes, C J 2023, ' SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension ', Circulation, vol. 147, no. 21, pp. 1606-1621 . https://doi.org/10.1161/CIRCULATIONAHA.122.061940

Background: Pulmonary arterial hypertension (PAH) is a rare disease characterized by remodeling of the pulmonary arteries, increased vascular resistance, and right-sided heart failure. Genome-wide association studies of idiopathic/heritable PAH estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d289ac157f18f26f95cb8c066dad6a
https://research.vumc.nl/en/publications/7d3b0e34-0272-44db-94f4-8bbba8efcf79

Application of [18F]FLT-PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers

Autor: Jurjan Aman, Marc C. Huisman, Anton Vonk Noordegraaf, Harm Jan Bogaard, Onno A. Spruijt, Ali Ashek, Liza Botros, Hans Harms, Lan Zhao, Frances S. de Man, Jelco Tramper, Samara M.A. Jansen

Publikováno v: Pulmonary Circulation, 11(3). University of Chicago Press
Pulmonary Circulation, Vol 11 (2021)
Botros, L, Jansen, S M A, Ashek, A, Spruijt, O A, Tramper, J, Noordegraaf, A V, Aman, J, Harms, H, de Man, F S, Huisman, M C, Zhao, L & Bogaard, H J 2021, ' Application of [18F]FLT-PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers ', Pulmonary Circulation, vol. 11, no. 3 . https://doi.org/10.1177/20458940211028017
Pulmonary Circulation

Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3′-deoxy-3′-[18F]-fluorot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f32f60b4082090358aa6f4c44f190e
https://doi.org/10.1177/20458940211028017