Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ali, Shawki"'
Autor:
Poonamjot Deol, Paul Ruegger, Geoffrey D. Logan, Ali Shawki, Jiang Li, Jonathan D. Mitchell, Jacqueline Yu, Varadh Piamthai, Sarah H. Radi, Sana Hasnain, Kamil Borkowski, John W. Newman, Declan F. McCole, Meera G. Nair, Ansel Hsiao, James Borneman, Frances M. Sladek
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTInflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18
Externí odkaz:
https://doaj.org/article/5cd2f4244d6b4c3b8efb161aa4fbaa8c
Autor:
Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 39-62 (2023)
Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage comm
Externí odkaz:
https://doaj.org/article/6312182efc1f47dca7056b2a59fb791d
Autor:
Marianne R. Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli’sa Crawford, Alina N. Santos, Pritha Chatterjee, Jiang Li, Meera G. Nair, Declan F. McCole
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Macrophages intimately interact with intestinal epithelial cells, but the consequences of defective macrophage–epithelial cell interactions for protection against enteric pathogens are poorly understood. Here, we show that in mice with a deletion i
Externí odkaz:
https://doaj.org/article/4a7e0dcb82a94f50a7e8005e4bb6f94c
Autor:
Ali Shawki, Rocio Ramirez, Marianne R. Spalinger, Paul M. Ruegger, Anica Sayoc-Becerra, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, Jonathan D. Mitchell, John C. Macbeth, Casey M. Gries, Michel L. Tremblay, Ansel Hsiao, James Borneman, Declan F. McCole
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1547-1566 (2020)
Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene incr
Externí odkaz:
https://doaj.org/article/20562da928e4413393bb29a2492d7c9e
Autor:
Chandrika N. Deshpande, T. Alex Ruwe, Ali Shawki, Vicky Xin, Kyle R. Vieth, Erika V. Valore, Bo Qiao, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that
Externí odkaz:
https://doaj.org/article/61dff6b0396e40ccba89522883e761ae
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary
Autor:
Ali Shawki, Declan F. McCole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 41-50 (2017)
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens. Inflammation pl
Externí odkaz:
https://doaj.org/article/d057e4e8cd454d36a50368b51a83af3e
Autor:
Pritha Chatterjee, Marianne Spalinger, Ali Shawki, Alina Santos, Anica Sayoc, Hillmin Lei, Saloman Manz, Meli'sa Crawford, Vinicius Canale, James Borneman, Declan McCole
Publikováno v:
Physiology. 38
Background: Alterations in epithelial tight junction proteins can compromise the ability of the intestinal mucosa to act as a barrier between luminal contents and underlying tissues. The resulting increase in intestinal permeability can give rise to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a8c158215c272d9da8047e42553a441
https://doi.org/10.1152/physiol.2023.38.s1.5734009
https://doi.org/10.1152/physiol.2023.38.s1.5734009
Autor:
Hillmin Lei, Ali Shawki, Marianne Spalinger, Vinicius Canale, Alina Santos, Pritha Chatterjee, Meli’sa Crawford, Salomon Manz, Michael Scharl, Declan McCole
Publikováno v:
Physiology. 38
Background: Anemia is the most frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and is associated with the risk of Crohn’s disease. Anemia significantly impairs quality of life, increases hospitalization rates, and increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8533cac3dcfc83ce1f7aecedc3379dbe
https://doi.org/10.1152/physiol.2023.38.s1.5725802
https://doi.org/10.1152/physiol.2023.38.s1.5725802
Autor:
Ali Shawki, Declan F. McCole, Sarah D Bobardt, Jiang Li, Marianne R. Spalinger, Pritha Chatterjee, Meera G. Nair, Anica Sayoc-Becerra, Meli’sa S. Crawford, Alina N. Santos
Publikováno v:
Mucosal immunology, vol 15, iss 1
Mucosal Immunology
Mucosal Immunology
Macrophages are a heterogeneous population of innate immune cells that are often divided into two major subsets: classically activated, typically pro-inflammatory (M1) macrophages that mediate host defense, and alternatively activated, tolerance-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de157ee2100aea15e41e4f8908e4e87
https://doi.org/10.1038/s41385-021-00441-3
https://doi.org/10.1038/s41385-021-00441-3
Autor:
Pritha Chatterjee, Marianne Spalinger, Ali Shawki, Alina Santos, Casey Gries, Anica Sayoc, Vinicus Canale, Meli'sa Crawford, Hillmin Lei, James Borneman, Declan McCole
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd3815aae9efc9397f16855defae1f1
https://doi.org/10.1096/fasebj.2022.36.s1.r2659
https://doi.org/10.1096/fasebj.2022.36.s1.r2659