Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations

Autor: Chen, Ji Yih, Wu, Yee Ling, Mok, Mo Yin, Wu, Yeong-Jian Jan, Lintner, Katherine E., Wang, Chin-Man, Chung, Erwin K., Yang, Yan, Zhou, Bi, Wang, Huanyu, Yu, Dennis, Alhomosh, Alaaedin, Jones, Karla, Spencer, Charles H., Nagaraja, Haikady N., Lau, Yu Lung, Lau, Chak-Sing, Yu, C. Yung

Human complement C4 is complex, with multiple layers of diversity. The aims of this study were to elucidate the copy number variations (CNVs) of C4A and C4B in relation to disease risk in systemic lupus erythematosus (SLE), and to compare the basis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4042854f94c2fedf1dbe3366a23053a
https://europepmc.org/articles/PMC5114127/

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

Autor: Yih Chen, Ji, Ling Wu, Yee, Yin Mok, Mo, Jan Wu, Yeong‐Jian, Lintner, Katherine E., Wang, Chin‐Man, Chung, Erwin K., Yang, Yan, Zhou, Bi, Wang, Huanyu, Yu, Denise J. H. C., Alhomosh, Alaaedin, Jones, Karla, Spencer, Charles H., Nagaraja, Haikady N., Lung Lau, Yu, Lau, Chak‐Sing, Yung Yu, C.

Publikováno v: Arthritis & Rheumatology; Jun2016, Vol. 68 Issue 6, p1442-1453, 12p

Adrenal crisis in a patient with acute myeloid leukaemia.

Autor: Li, Wang, Okwuwa, Ikemefuna, Toledo-Frazzini, Karla, Alhomosh, Alaaedin

Publikováno v: BMJ Case Reports; Jul2013, p1-3, 3p, 1 Color Photograph, 1 Black and White Photograph

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

Autor: Chen JY; Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan, Republic of China., Wu YL; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Mok MY; Division of Rheumatology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Wu YJ; Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan, Republic of China., Lintner KE; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Wang CM; Department of Rehabilitation, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan, Republic of China., Chung EK; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Yang Y; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Zhou B; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Wang H; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Yu D; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Alhomosh A; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Jones K; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Spencer CH; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA., Nagaraja HN; Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio 43201, USA., Lau YL; Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lau CS; Division of Rheumatology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Yu CY; Center for Molecular and Human Genetics, The Research Institute and Division of Pediatric Rheumatology, Nationwide Children's Hospital; and Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2016 Jun; Vol. 68 (6), pp. 1442-1453.