Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives.

Autor: Alho DPS; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.; Centre for Neuroscience and Cell Biology, 3000-504 Coimbra, Portugal., Salvador JAR; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. salvador@ci.uc.pt.; Centre for Neuroscience and Cell Biology, 3000-504 Coimbra, Portugal. salvador@ci.uc.pt., Cascante M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain., Marin S; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. silviamarin@ub.edu.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. silviamarin@ub.edu.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2019 Aug 14; Vol. 24 (16). Date of Electronic Publication: 2019 Aug 14.

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

Autor: Salvador JAR; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal. Electronic address: salvador@ci.uc.pt., Leal AS; Michigan State University, Department of Pharmacology and Toxicology, Life Science Building 1355, Bogue St Room 430, USA., Valdeira AS; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Gonçalves BMF; Center for Neuroscience and Cell Biology, Coimbra, Portugal; CHEM4PHARMA, Biocant - Parque Tecnológico de Cantanhede, Núcleo 4, Lote 14, 3060-197, Cantanhede, Portugal., Alho DPS; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Figueiredo SAC; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Silvestre SM; Center for Neuroscience and Cell Biology, Coimbra, Portugal; CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal., Mendes VIS; Center for Neuroscience and Cell Biology, Coimbra, Portugal; CHEM4PHARMA, Biocant - Parque Tecnológico de Cantanhede, Núcleo 4, Lote 14, 3060-197, Cantanhede, Portugal.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2017 Dec 15; Vol. 142, pp. 95-130. Date of Electronic Publication: 2017 Jul 14.