Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alham Saadat"'
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Reducing disparities is vital for equitable access to precision treatments in cancer. Socioenvironmental factors are a major driver of disparities, but differences in genetic variation likely also contribute. The impact of genetic ancestry o
Externí odkaz:
https://doaj.org/article/f5fc9a4be68842a79c2275a29dc90764
Autor:
Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spegel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W Franks, Sebastian Kalamajski
Publikováno v:
eLife, Vol 12 (2023)
Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to m
Externí odkaz:
https://doaj.org/article/ec3b46da82fb44d690ce61ef78e46cc2
Autor:
Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides
Externí odkaz:
https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1
Autor:
Mi Huang, Melina Claussnitzer, Alham Saadat, Daniel E. Coral, Sebastian Kalamajski, Paul W. Franks
Publikováno v:
Diabetologia.
Aims/hypothesis PPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been ass
Autor:
Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spegel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W Franks, Sebastian Kalamajski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a6869dfc170e167d527fef9fcef9c95
https://doi.org/10.7554/elife.84168.sa2
https://doi.org/10.7554/elife.84168.sa2
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David Root, James McFarland, Rameen Beroukhim, Jesse S. Boehm
Reducing disparities is critical to promote equity of access to precision treatments for all patients with cancer. While socioenvironmental factors are a major driver behind such disparities, biological differences also are likely to contribute. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0df55af9b2b0a3fe1d1e8632f4f48ec
https://doi.org/10.1101/2022.11.18.517155
https://doi.org/10.1101/2022.11.18.517155
Autor:
Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spégel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W. Franks, Sebastian Kalamajski
BackgroundGenetic variation at theMTIF3(Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known.MethodsHere, we applied luciferase repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e183f10b4394de33cf879ceb83d6ea4
https://doi.org/10.1101/2022.10.16.512435
https://doi.org/10.1101/2022.10.16.512435
Autor:
Stephanie S. Lee, Michelle Weitz, Kristin Ardlie, Amy Bantham, Michele Fronk Schuckel, Katey Goehringer, Caitlin Hogue, Rosy Hosking, Kathleen Mortimer, Alham Saadat, Jill Seaman‐Chandler, Benjamin P. Linas, Andrea Ciaranello
Publikováno v:
The Journal of school health. 92(5)
ImportanceCDC guidance emphasizes the importance of in-person education for students in grades kindergarten to 12 (K-12) during the COVID-19 pandemic. CDC encourage weekly SARS-CoV-2 testing of asymptomatic, unvaccinated students and staff (“screen
Autor:
Garrett Garborcauskas, Alycen Harney, Hesam Dashti, Anne E. Carpenter, Miriam S. Udler, Elizabeth McGonagle, Aaron Leong, Hannah Ebert, Josée Dupuis, Maria Kost-Alimova, Cecilia M. Lindgren, Sierra Harken, Giacomo Deodato, Hans Hauner, Beth A. Cimini, Suzanne B.R. Jacobs, Josep M. Mercader, Saskia Reibe-Pal, Jose C. Florez, Adam Stefek, Samantha Laber, David R. Stirling, Gregory P. Way, Nasa Sinnott-Armstrong, Katherine Figueroa, Julius Honecker, Alham Saadat, Alina Ainbinder, Virtudes Calabuig, Melina Claussnitzer, Yixin Zhang, Sophie Strobel
SummaryA primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants and genes associated with human diseases. Broadly applicable high-throughput, unbiased a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e99c4f7b03bd908d4d964e2603077b
https://doi.org/10.1101/2021.07.17.452050
https://doi.org/10.1101/2021.07.17.452050
Autor:
Melina Claussnitzer, Alham Saadat, Manolis Kellis, Xinchen Wang, Liang He, Li Wang, Nasa Sinnott-Armstrong, Sarah M. Goggin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
Genome-wide epigenomic maps have revealed millions of putative enhancers and promoters, but experimental validation of their function and high-resolution dissection of their driver nucleotides remain limited. Here, we present HiDRA (High-resolution D