Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Algirdas Mikalkėnas"'
Autor:
Algirdas Mikalkėnas, Bazilė Ravoitytė, Daiva Tauraitė, Elena Servienė, Rolandas Meškys, Saulius Serva
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 384-389 (2018)
Small molecule inhibitors have a powerful blocking action on viral polymerases. The bioavailability of the inhibitor, nevertheless, often raise a significant selectivity constraint and may substantially limit the efficacy of therapy. Phosphonoacetic
Externí odkaz:
https://doaj.org/article/f77653e475894f209699d0402048b96e
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 35:163-177
The synthesis and characterization of novel acyclic and cyclic pyridone-based nucleosides and nucleotides is described. In total, seven nucleosides and four nucleotides were synthesized. None of the tested nucleosides showed inhibitory properties aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0091d31936b1e157c57610100b2db9ab
https://doi.org/10.1080/15257770.2015.1122197
https://doi.org/10.1080/15257770.2015.1122197
Publikováno v:
Biologija. 63
Novel pyridone-based nucleotides were investigated for maintenance of DNA synthesis, carried on by representatives of different classes of polymerases. Five different nucleoside triphosphates of similar structure were addressed, demonstrating involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a7799558f02ad705fcd9c6e49aa74b
https://doi.org/10.6001/biologija.v63i1.3473
https://doi.org/10.6001/biologija.v63i1.3473