Výsledky vyhledávání - "Alfredo R. Arocena"

Akademický článek

Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders.

Autor: Luisina I Onofrio, Alfredo R Arocena, Augusto F Paroli, María E Cabalén, Marta C Andrada, Roxana C Cano, Susana Gea

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003464 (2015)

BACKGROUND:The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH), and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood. METHODOLOGY/

Externí odkaz: https://doaj.org/article/1d392c7a0b634562bf05ba9b9e6d212d

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NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection

Autor: Luisina Inés Onofrio, Cintia Díaz-Luján, Susana Gea, Patricia Verónica Gonzalez, Eugenio A Carrera-Silva, Augusto Fabián Paroli, Alfredo R. Arocena, Roxana Carolina Cano

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology

Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d608d56c5762e3a3de794b06e22e9344
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00913/full

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Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders

Autor: Marta Cecilia Andrada, Augusto Fabián Paroli, Luisina Inés Onofrio, María Eugenia Cabalén, Susana Gea, Roxana Carolina Cano, Alfredo R. Arocena

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003464 (2015)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases

Background The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH), and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood. Methodology/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a110e0f0b9fe295e86c65938ffabf677
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003464

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Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection

Autor: Augusto Fabián Paroli, Roxana Carolina Cano, Alfredo R. Arocena, Luisina Inés Onofrio, Susana Gea, Andrea Pellegrini, Antonio E. Carrera Silva, Maria P. Aoki

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Myeloid-derived suppressor cells (MDSCs) are key players in the immune suppressivenetwork. During acute infection with the causative agent of Chagas disease,Trypanosomacruzi, BALB/c mice show less inflammation and better survival than C57BL/6 (B6) mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500961679f5e75e36bd32d327020fc10
Wiley Online Library

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Importance of TLR2 on Hepatic Immune and Non-Immune Cells to Attenuate the Strong Inflammatory Liver Response During Trypanosoma cruzi Acute Infection

Autor: Alfredo R. Arocena, Roxana Carolina Cano, Maria Pilar Aoki, Natalia Guiñazú, Andrea Pellegrini, Susana Gea, Eugenio Antonio Carrera-Silva

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 4, Iss 11, p e863 (2010)

Background Toll-like receptors (TLR) and cytokines play a central role in the pathogen clearance as well as in pathological processes. Recently, we reported that TLR2, TLR4 and TLR9 are differentially modulated in injured livers from BALB/c and C57BL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d292782a2b742393ce7956bff5dfba
http://europepmc.org/articles/PMC2970533

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