Bioremediation, drought tolerance and biofortification in biotechnological uses

Autor: Bruna DalPizol Novello, Marcela Maria Zanatta, Felipe Pompolim Mendes, Alfredo Paiola Albrecht, Arthur Arrobas Martins Barroso

Publikováno v: Acta Scientiarum: Biological Sciences, Vol 45, Iss 1 (2023)

The objective of this review is to bring information about innovations and technologies that, through genetic improvement, are being used to improve the sustainability and productivity of agricultural crops, improve human nutrition, as well as conser

Externí odkaz: https://doaj.org/article/c8d7396ceebb4e9ea02b251293641c68

An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer

Autor: Paolo Rovero, Alfredo Paio, Annunziata D’Ercole, Matteo Zini, Francesca Nuti, L. Pacini, Anna Maria Papini, Arianna Ribecai, Giuseppina Sabatino

Publikováno v: Organic process research & development 25 (2021): 2754–2771. doi:10.1021/acs.oprd.1c00368
info:cnr-pdr/source/autori:D'Ercole, Annunziata; Pacini, Lorenzo; Sabatino, Giuseppina; Zini, Matteo; Nuti, Francesca; Ribecai, Arianna; Paio, Alfredo; Rovero, Paolo; Papini, Anna Maria/titolo:An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer/doi:10.1021%2Facs.oprd.1c00368/rivista:Organic process research & development/anno:2021/pagina_da:2754/pagina_a:2771/intervallo_pagine:2754–2771/volume:25

A growing industrial interest toward the peptide drug market fueled the need for the development of effective and cGMP compliant manufacturing methods for these complex molecules. Solid-phase strategies are considered methods of election for medium-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29c2a766b49246c4ffd343dfd85a016
https://publications.cnr.it/doc/464122

Synthesis and Structure–Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics

Autor: Daniele Donati, Stefano Biondi, Alfredo Paio, Stjepan Mutak, Sergio Lociuro, Elisa Piga, Francesca Cardullo, Dražen Pavlović, Daniele Andreotti

Publikováno v: ACS Medicinal Chemistry Letters. 5:1133-1137

An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8c82745e0260869ef5d53f6e44524e
https://doi.org/10.1021/ml500279k

Synthesis of 5-(3,4-dichlorophenyl)-4-[(methyloxy)methyl]-2-azabicyclo[3.2.1]octane derivatives as constrained aryl-piperidines with activity as triple re-uptake inhibitors

Autor: Daniele Andreotti, Roberto Profeta, Alfredo Paio, Simone Spada, Francesco Ferroni, Jens Klein

Publikováno v: Tetrahedron Letters. 51:5521-5524

Stereochemical and synthetic aspects encountered during the preparation of the four possible isomers of 1 are reported. The 5-aryl 2-azabicyclo [3.2.1] octane derivatives represent a novel class of compounds which can be deemed as an example of aryl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a9af09b68927810407ff57c9b2f1aa6
https://doi.org/10.1016/j.tetlet.2010.07.145

Polymer-Supported Haloarene Chromium Dicarbonyl Isonitrile Complexes: A Study of Their Synthesis and Reactivity

Autor: Giovanna Zinzalla, Carla Marchioro, Laura Casiraghi, Stefano Maiorana, Clara Baldoli, Elisabetta de Magistris, Pierfausto Seneci, and Alfredo Paio, Emanuela Licandro

Publikováno v: Journal of Combinatorial Chemistry. 5:809-813

Different arene Cr(CO)(3) complexes were supported on a polystyrene isonitrile resin by photochemical-promoted replacement of a chromium carbonyl ligand by the NC group. The supported complexes proved to be stable and were successfully used for furth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefdddcaaabc2d9c1f6606b85b493db9
https://doi.org/10.1021/cc0340123