Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alfredo Lanzaro"'
Autor:
Alfredo Lanzaro
Publikováno v:
SN Applied Sciences, Vol 3, Iss 9, Pp 1-10 (2021)
Abstract Subcutaneous injection by means of prefilled syringes allows patients to self-administrate high-concentration (100 g/L or more) protein-based drugs. Although the shear flow of concentrated globulins or monoclonal antibodies has been intensiv
Externí odkaz:
https://doaj.org/article/1ef6d2b5130f43a09c7db1ebd47df290
Autor:
Alfredo Lanzaro, Xue-Feng Yuan
Publikováno v:
Micromachines, Vol 13, Iss 2, p 256 (2022)
We introduce a “Rheo-chip” prototypical rheometer which is able to characterise model fluids under oscillatory flow at frequencies f up to 80 Hz and nominal strain up to 350, with sample consumption of less than 1 mL, and with minimum inertial ef
Externí odkaz:
https://doaj.org/article/36ff26aa707441598c1ad2d9d622f5aa
Autor:
Amjad Chowdhury, Neha Manohar, Geetika Guruprasad, Amy T. Chen, Alfredo Lanzaro, Marco Blanco, Keith P. Johnston, Thomas M. Truskett
Publikováno v:
The Journal of Physical Chemistry B. 127:1120-1137
Autor:
Amjad A. Chowdhury, Neha Manohar, Marta A. Witek, Mahlet A. Woldeyes, Ranajoy Majumdar, Ken K. Qian, William D. Kimball, Shifeng Xu, Alfredo Lanzaro, Thomas M. Truskett, Keith P. Johnston
Publikováno v:
Molecular Pharmaceutics.
Publikováno v:
Chinese Journal of Polymer Science. 40:1432-1440
Autor:
Robin Curtis, Maryam Shah, Shahid Uddin, Peter Davis, Daniel Corbett, C. F. van der Walle, Aisling Roche, Nicole Sibanda, Alain Pluen, Alfredo Lanzaro
Publikováno v:
Shah, M, Corbett, D, Lanzaro, A, Roche, A, Sibanda, N, Davis, P, Uddin, S, van der Walle, C F, Curtis, R & Pluen, A 2020, ' Micro-and macro-viscosity relations in high concentration antibody solutions ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 153, 10.1016/j.ejpb.2020.06.007, pp. 211-221 . https://doi.org/10.1016/j.ejpb.2020.06.007
Molecular crowding in highly concentrated monoclonal antibody (mAb) solutions results in significant increases in viscosity, which complicates fill-finish steps and patient administration by subcutaneous injection. As viscosity measurements for optim
Publikováno v:
Journal of Non-Newtonian Fluid Mechanics. 242:57-65
We have characterised the flow of semi-dilute PAAm solutions (3.3c* ≤ c ≤ 16.6c*) through a three-dimensional cross-slot device (width to depth aspect ratio 2: 1) over a range of Weissenberg (0.13 ≤ Wi ≤ 88.5) and Elasticity (1.5 ≤ El ≤ 5
Publikováno v:
Microfluidics and Nanofluidics. 18:819-828
Nonlinear flows of polyacrylamide (PAAm) ( $$M_{\text{w}} = 5.7 \times 10^{6}\,{\text{g}}/{\text{mol}}$$ ) aqueous solutions through a micro-fabricated, hyperbolic contraction geometry with high Hencky strain ( $$\varepsilon_{{\text{H}}} = 3.7$$ ) ha
Autor:
Xue Feng Yuan, Alfredo Lanzaro
Publikováno v:
Journal of Non-Newtonian Fluid Mechanics. 207:32-41
A numerical method is proposed to calculate local extensional rate along arbitrary streamlines measured experimentally. It leads to the calculation of a “local Deborah number” (De) field, which characterizes heterogeneous flows of polymer solutio
Autor:
Xue Feng Yuan, Alfredo Lanzaro
Publikováno v:
Journal of Non-Newtonian Fluid Mechanics. 166:1064-1075
Highly non-linear flows of semi-dilute ð3:3 6 c=c � 6 16:6Þ polyacrylamide (PAAm) aqueous solutions through three micro-fabricated 4:1:4, 8:1:8 and 16:1:16 contraction–expansion geometries have been investigated by micro-particle imaging veloci