Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alfredo Gonzalez-Sulser"'
Autor:
Grant F. Marshall, Melissa Fasol, Faith C. J. Davies, Matthew Le Seelleur, Alejandra Fernandez Alvarez, Cavan Bennett-Ness, Alfredo Gonzalez-Sulser, Catherine M. Abbott
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/56c3302572a5435cb351a33c1a994ccb
Autor:
Katherine Bonnycastle, Katharine L. Dobson, Eva-Maria Blumrich, Akshada Gajbhiye, Elizabeth C. Davenport, Marie Pronot, Moritz Steinruecke, Matthias Trost, Alfredo Gonzalez-Sulser, Michael A. Cousin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Dynamin-1 is a large GTPase with an obligatory role in synaptic vesicle endocytosis at mammalian nerve terminals. Heterozygous missense mutations in the dynamin-1 gene (DNM1) cause a novel form of epileptic encephalopathy, with pathogenic mu
Externí odkaz:
https://doaj.org/article/978480a973bf49a58749c29e55169d7b
Autor:
Ingrid Buller-Peralta, Katerina Hristova, Alejandro Bassi, Sally Till, Adrian Ocampo-Garces, Peter Kind, Alfredo Gonzalez-Sulser
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss Suppl 1 (2021)
Externí odkaz:
https://doaj.org/article/12b63fd99d6c40ce95aaf698a08bc5bd
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 3 (2021)
In most mouse models of disease, the outward manifestation of a disorder can be measured easily, can be assessed with a trivial test such as hind limb clasping, or can even be observed simply by comparing the gross morphological characteristics of mu
Externí odkaz:
https://doaj.org/article/9d8e0984c86e4068827e3540acc1fc2c
Autor:
Thomas C Watson, Katerina Hristova, Alfredo Gonzalez-Sulser, Cristina Martinez-Gonzalez, Kevan Hashemi, Neela K. Codadu, Matthew F. Nolan, Peter C. Kind
Publikováno v:
Brain
Hristova, K, Martinez Gonzalez, C, Watson, T, Codadu, N, Hashemi, K, Kind, P, Nolan, M & Gonzalez-Sulser, A 2021, ' Medial Septal GABAergic Neurons Reduce Seizure Duration Upon Optogenetic Closed-Loop Stimulation ', Brain, vol. 144, no. 5, pp. 1576–1589 . https://doi.org/10.1093/brain/awab042
Hristova, K, Martinez Gonzalez, C, Watson, T, Codadu, N, Hashemi, K, Kind, P, Nolan, M & Gonzalez-Sulser, A 2021, ' Medial Septal GABAergic Neurons Reduce Seizure Duration Upon Optogenetic Closed-Loop Stimulation ', Brain, vol. 144, no. 5, pp. 1576–1589 . https://doi.org/10.1093/brain/awab042
Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3519087d6305deed7ad76b00b2b8e37a
http://europepmc.org/articles/PMC8219369
http://europepmc.org/articles/PMC8219369
Autor:
Alfredo Gonzalez-Sulser
Publikováno v:
Gonzalez-Sulser, A 2022, ' New inroads into the brain circuits and network dynamics behind sudden unexpected death in epilepsy ', Brain Communications, vol. 4, no. 2, fcac097 . https://doi.org/10.1093/braincomms/fcac097
This scientific commentary refers to ‘Hyperexcitable superior colliculus and fatal brainstem spreading depolarization in a model of sudden unexpected death in epilepsy’ by Cain et al. (https://doi.org/10.1093/braincomms/fcac006) and ‘Ictal neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdb4039c2372ee8f0906c38179efe5a
https://www.pure.ed.ac.uk/ws/files/261455548/GonzalezSulser_2022_v2.pdf
https://www.pure.ed.ac.uk/ws/files/261455548/GonzalezSulser_2022_v2.pdf
Autor:
Ingrid, Buller-Peralta, Jorge, Maicas-Royo, Zhuoen, Lu, Sally M, Till, Emma R, Wood, Peter C, Kind, Javier, Escudero, Alfredo, Gonzalez-Sulser
Publikováno v:
Brain communications. 4(6)
Mutations in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dce5458d4c2441c5b3533947697f2c7
https://pubmed.ncbi.nlm.nih.gov/36349120
https://pubmed.ncbi.nlm.nih.gov/36349120
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 3 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Marshall, G, Gonzalez-Sulser, A & Abbott, C M 2021, ' Modelling epilepsy in the mouse: challenges and solutions ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.047449
Disease Models & Mechanisms
article-version (VoR) Version of Record
Marshall, G, Gonzalez-Sulser, A & Abbott, C M 2021, ' Modelling epilepsy in the mouse: challenges and solutions ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.047449
In most mouse models of disease, the outward manifestation of a disorder can be measured easily, can be assessed with a trivial test such as hind limb clasping, or can even be observed simply by comparing the gross morphological characteristics of mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5bd47b8b4d5ba07607d04ab4d1ff19
https://doi.org/10.1242/dmm.047449
https://doi.org/10.1242/dmm.047449
Autor:
Oliver Hardt, Alfredo Gonzalez-Sulser, I. Buller-Peralta, Jacqueline Smith, S. Biswal, Michael A. Cousin, Nicholas Perentos, Daisy Arkell, V. Kapgal, Peter C. Kind, M. S. Nawaz, Danai Katsanevaki, Emma R. Wood, Sally M. Till, Natasha J. Anstey, Thomas C Watson, S. Tiwari, L. Mizen, Matt Jones, Sumantra Chattarji
Pathogenic variants in SYNGAP1 are one of the most common genetic causes of nonsyndromic intellectual disability (ID) and are considered a risk for autism spectrum disorder (ASD). SYNGAP1 encodes a synaptic GTPase activating protein that modulates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b55f8a496b2614deb02d23f736d9fcf
https://doi.org/10.1101/2020.10.14.339192
https://doi.org/10.1101/2020.10.14.339192
Autor:
Alfredo Gonzalez-Sulser
Publikováno v:
Gonzalez-Sulser, A 2020, ' Rodent genetic models of neurodevelopmental disorders and epilepsy ', European Journal of Paediatric Neurology, vol. 24, pp. 66-69 . https://doi.org/10.1016/j.ejpn.2019.12.012
Neurodevelopmental disorders (NDDs) are characterised by cognitive, social and motor deficits and are highly comorbid with intractable epilepsies. Through advances in genetic sequencing technologies a vast number of genes have been implicated in NDDs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85efb9e1cdc54ad7ef905670bf1226d1
https://hdl.handle.net/20.500.11820/3ce5beee-d62a-426c-bf06-b2dfd66890ad
https://hdl.handle.net/20.500.11820/3ce5beee-d62a-426c-bf06-b2dfd66890ad