Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alfredo Darmanin-Sheehan"'
Autor:
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders, Caroline J. Barelle
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its
Externí odkaz:
https://doaj.org/article/2040fb960ade4e4a81c4768f6494230b
Autor:
Zhenwei Su, Jonathan Brooks, Jeffrey Pelker, Tatyana Andreyeva, Hanna Sobon, Roger Gifford, Matthew Powers, Jing Wang, Corey Dower, Martin Hegen, Dean Messing, Alfredo Darmanin Sheehan, Joseph J Brennan
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280590 (2023)
C-C motif chemokine receptor-like 2 (CCRL2) is a non-signaling 7 transmembrane receptor that binds chemotactic ligands to shape leukocyte recruitment to sites of inflammation. However, there is a lack of consensus on the ligands that directly bind CC
Externí odkaz:
https://doaj.org/article/706fbbb9092845e5af906b0160784666
Autor:
Orla Cunningham, Eric Sousa, Susan Benard, Yongjing Guo, C.M. Francis, Puja Sapra, Laura Lin, Lindsay King, Fang Jin, Weijun Ma, Aaron M. D’Antona, Nicole Piche-Nicholas, Sinead E. Keating, Sara Hanscom, Gurkan Guntas, Wayne Stochaj, Khetemcnee Lam, Claire Hendershot, Liliana Wroblewska, H. Lily Zhu, Kimberly Ann Marquette, Kristine Svenson, Divya Mathur, Fernando Narciandi, Yan Liu, Weili Duan, Edward R. Lavallie, Alison Betts, Rosemary Lawrence-Henderson, Chang Chew Shun, Adam Root, Maya Arai, Madan Katragadda, Amy King, Amy Tam, Jatin Narula, Jason Wade, Kerry Kelleher, Lioudmila Tchistiakova, Lidia Mosyak, Alfredo Darmanin Sheehan, Han Yang, Yan Zhang, James R. Apgar, Edward Rosfjord, Laird Bloom, Caryl L. Meade, Matthew McKenna
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Autor:
Marina Kovaleva, Kenneth Saunders, Caroline J. Barelle, Matthew J. Whitters, Jiquan Zhang, Deborah Luxenberg, John Steven, Emma Cummins, Miguel F. Carvalho, Alfredo Darmanin-Sheehan, Ronan O’Dwyer
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Journal of Immunology Research
Journal of Immunology Research
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its
Autor:
Lioudmila Tchistiakova, Laird Bloom, Emma Cummins, Matthew Allister Lambert, William J.J. Finlay, Brian J. Fennell, Janet E. Paulsen, Deirdre Ní Shúilleabháin, Katarzyna Oficjalska, Orla Cunningham, Davinder Gill, Leeying Wu, Bénédicte Autin, Alfredo Darmanin-Sheehan
Publikováno v:
The Journal of Immunology. 188:322-333
Examination of 1269 unique naive chicken VH sequences showed that the majority of positions in the framework (FW) regions were maintained as germline, with high mutation rates observed in the CDRs. Many FW mutations could be clearly related to the mo
Autor:
Emma Cummins, Janet E. Paulsen, Orla Cunningham, Simon Evan Hufton, William J.J. Finlay, Nicole Piche, Debra D. Pittman, Alfredo Darmanin-Sheehan, Xiang Yang Tan, Lioudmila Tchistiakova, Matthew Allister Lambert, Xuemei Liu, Davinder Gill, Ciara M. Mahon, Cliona O'Sullivan, Jason M. Wade, Sreekumar Raman Kodangattil, Brian J. Fennell
Publikováno v:
Journal of Molecular Biology. 388:541-558
Antibodies that neutralize RAGE (receptor for advanced glycation end products)-ligand interactions have potential therapeutic applications in both acute and chronic diseases. We generated XT-M4, a rat anti-RAGE monoclonal antibody that has in vivo ef
Autor:
Emma Cummins, Alfredo Darmanin-Sheehan, Orla Cunningham, Deborah Luxenberg, Brian J. Fennell, Davinder Gill, Matthew J. Whitters, Laird Bloom, Fionnuala Mcaleese, Angela Widom
Publikováno v:
Journal of Immunological Methods. 339:38-46
Phage and ribosome display technologies have emerged as important tools in the high-throughput screening of protein pharmaceuticals. However, a challenge created by the implementation of such tools is the need to purify large numbers of proteins for
Autor:
Orla Cunningham, Janet E. Paulsen, Barry McDonnell, Lioudmila Tchistiakova, Deirdre Ní Shúilleabháin, Joanne Grant, Sue Townsend, Alfredo Darmanin-Sheehan, Niall J. Foy, Conor Fields, Jason Wade, Brian J. Fennell, James R. Apgar, Amy King, Matthew Allister Lambert, William J.J. Finlay, Edward Franklin, Timothy P. Hickling
Although humanized antibodies have been highly successful in the clinic, all current humanization techniques have potential limitations, such as: reliance on rodent hosts, immunogenicity due to high non-germ-line amino acid content, v-domain destabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3ff8e127331263ac7e7116548eddc4
https://europepmc.org/articles/PMC4687607/
https://europepmc.org/articles/PMC4687607/
Autor:
Deirdre Ní Shúilleabháin, John Steven, Elizabeth Kieras, Amy Tam, Matthew J. Whitters, Laird Bloom, Huilan Gao, Matthew McKenna, Brian J. Fennell, Lijun Chang, Orla Cunningham, Allan Jensen, Wenyan Miao, Mark R. H. Krebs, William J.J. Finlay, Alfredo Darmanin-Sheehan, Amy King, Janet E. Paulsen, Deborah Luxenberg, Lori Fitz, Yongjing J Guo, C.M. Francis, William S. Somers, Jason Edmonds, Laura Lin, Christopher Grace, Ian D. Broadbent, Timothy P. Hickling, Angela Boisvert, Barry McDonnell, Emma Cummins, Xiaotian Zhong, Jennifer Alley, Quintus G. Medley, Stephane Olland, Bénédicte Autin
Publikováno v:
mAbs
While myriad molecular formats for bispecific antibodies have been examined to date, the simplest structures are often based on the scFv. Issues with stability and manufacturability in scFv-based bispecific molecules, however, have been a significant
Autor:
Kristine Svenson, Ezio Bonvini, Alfredo Darmanin Sheehan, William J.J. Finlay, Paul A. Moore, Jocelyn Sanford, Chad May, Kelvin M. Kerns, Liqin Liu, Susan Benard, Aaron M. D’Antona, Steve Burke, Scott Gatto, Hua Li, Syd Johnson, Hans-Peter Gerber, Yinhua Yang, Edward R. Lavallie, Gurunadh Reddy Chichili, Lioudmila Tchistiakova, Tao He, Peter LaPan, Stephane Olland, William Brady, Khetemenee Lam, Cliona M. O'Sullivan, Wei Cao, Laura Lin, Adam Root, William S. Somers, Bilian Li, Ralph Alderson, Macy Jin, Lisa Racie, Lily Zhu, Weijun Ma, Caryl L. Meade, Lidia Mosyak, Wayne Stochaj, Amy King, Emma Cummins, Matthew Allister Lambert, Laird Bloom, Dianah Barrett, James R. Apgar, Maya Arai
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Antibodies; Volume 5; Issue 1; Pages: 6
Antibodies
Antibodies; Volume 5; Issue 1; Pages: 6
Antibodies
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec