Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Alfredo Castello"'
Autor:
Stephanie M. Rainey, Vincent Geoghegan, Daniella A. Lefteri, Thomas H. Ant, Julien Martinez, Cameron J. McNamara, Wael Kamel, Zaydah Rolande de Laurent, Alfredo Castello, Steven P. Sinkins
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Some strains of the inherited bacterium Wolbachia have been shown to be effective at reducing the transmission of dengue virus (DENV) and other RNA viruses by Aedes aegypti in both laboratory and field settings and are being deployed for DEN
Externí odkaz:
https://doaj.org/article/bb6e683150e0411cae705926cd39ed1f
Autor:
Jeffrey Y Lee, Peter AC Wing, Dalia S Gala, Marko Noerenberg, Aino I Järvelin, Joshua Titlow, Xiaodong Zhuang, Natasha Palmalux, Louisa Iselin, Mary Kay Thompson, Richard M Parton, Maria Prange-Barczynska, Alan Wainman, Francisco J Salguero, Tammie Bishop, Daniel Agranoff, William James, Alfredo Castello, Jane A McKeating, Ilan Davis
Publikováno v:
eLife, Vol 11 (2022)
Despite an unprecedented global research effort on SARS-CoV-2, early replication events remain poorly understood. Given the clinical importance of emergent viral variants with increased transmission, there is an urgent need to understand the early st
Externí odkaz:
https://doaj.org/article/9faa31e3a35e4bed8c3ceedffa1e3c5f
Autor:
Andrew E Shaw, Suzannah J Rihn, Nardus Mollentze, Arthur Wickenhagen, Douglas G Stewart, Richard J Orton, Srikeerthana Kuchi, Siddharth Bakshi, Mila Rodriguez Collados, Matthew L Turnbull, Joseph Busby, Quan Gu, Katherine Smollett, Connor G G Bamford, Elena Sugrue, Paul C D Johnson, Ana Filipe Da Silva, Alfredo Castello, Daniel G Streicker, David L Robertson, Massimo Palmarini, Sam J Wilson
Publikováno v:
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Externí odkaz:
https://doaj.org/article/93c6a324bb0649b4bf2748908f349e90
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
Autor:
Peter A.C. Wing, Thomas P. Keeley, Xiaodong Zhuang, Jeffrey Y. Lee, Maria Prange-Barczynska, Senko Tsukuda, Sophie B. Morgan, Adam C. Harding, Isobel L.A. Argles, Samvid Kurlekar, Marko Noerenberg, Craig P. Thompson, Kuan-Ying A. Huang, Peter Balfe, Koichi Watashi, Alfredo Castello, Timothy S.C. Hinks, William James, Peter J. Ratcliffe, Ilan Davis, Emma J. Hodson, Tammie Bishop, Jane A. McKeating
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109020- (2021)
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension,
Externí odkaz:
https://doaj.org/article/0e81e8390d8b4bff8a888f023b7b0038
Publikováno v:
Open Biology, Vol 10, Iss 12 (2020)
The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are perceived by the host machinery as defective and are retained in the nucle
Externí odkaz:
https://doaj.org/article/7f261dfb83514a8483bca361a7bfc5e2
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
Autor:
Fruzsina Hobor, Andre Dallmann, Neil J. Ball, Carla Cicchini, Cecilia Battistelli, Roksana W. Ogrodowicz, Evangelos Christodoulou, Stephen R. Martin, Alfredo Castello, Marco Tripodi, Ian A. Taylor, Andres Ramos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Syncrip is a conserved RNA-binding protein that mediates selective miRNA loading into cell-secreted exosomes, which is important for cell–cell communication. Here the authors provide mechanistic insights into how Syncrip recognises its target miRNA
Externí odkaz:
https://doaj.org/article/e8b59054a2c04f5fa6bc358e84c2ef95
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
Autor:
Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-20 (2017)
Abstract Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related r
Externí odkaz:
https://doaj.org/article/2f8e9d8eaf534683ae8abdef33ed476b
Autor:
Yalin Liao, Alfredo Castello, Bernd Fischer, Stefan Leicht, Sophia Föehr, Christian K. Frese, Chikako Ragan, Sebastian Kurscheid, Eloisa Pagler, Hao Yang, Jeroen Krijgsveld, Matthias W. Hentze, Thomas Preiss
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1456-1469 (2016)
RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL-1 cells by jointly employing two in vivo proteomic methods, mRNA interactom
Externí odkaz:
https://doaj.org/article/067299274f904368916a5098e226b4ce
Autor:
Vasiliy O. Sysoev, Bernd Fischer, Christian K. Frese, Ishaan Gupta, Jeroen Krijgsveld, Matthias W. Hentze, Alfredo Castello, Anne Ephrussi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Early development is controlled by maternally deposited mRNAs and the RNA-binding proteins (RBPs) that regulate them. Here the authors describe the identification of a large number of RBPs bound to polyadenylated RNAs in Drosophilaembryos before and
Externí odkaz:
https://doaj.org/article/2fbe552daba04c8d8a620555ac971d55
Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method
Autor:
Marcel Bach-Pages, Felix Homma, Jiorgos Kourelis, Farnusch Kaschani, Shabaz Mohammed, Markus Kaiser, Renier A. L. van der Hoorn, Alfredo Castello, Gail M. Preston
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 661 (2020)
RNA-binding proteins (RBPs) play a crucial role in regulating RNA function and fate. However, the full complement of RBPs has only recently begun to be uncovered through proteome-wide approaches such as RNA interactome capture (RIC). RIC has been app
Externí odkaz:
https://doaj.org/article/a8694706628543f4a068aa4b983b31ce