Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alfredo C Castro"'
Autor:
Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes wi
Externí odkaz:
https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b
Autor:
Jeffrey Ecsedy, Xiaoyan M. Zhang, Mark Manfredi, Prabitha Natarajan, Sakeena Syed, Jeremy Tchaicha, Meghan Walsh, Silvia Coma, Jill Cavanaugh, Alfredo C. Castro, Karen McGovern
Supplementary Table from Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a11276840ac47ab69018568d15800d
https://doi.org/10.1158/1535-7163.22523289.v1
https://doi.org/10.1158/1535-7163.22523289.v1
Autor:
Jeffrey Ecsedy, Xiaoyan M. Zhang, Mark Manfredi, Prabitha Natarajan, Sakeena Syed, Jeremy Tchaicha, Meghan Walsh, Silvia Coma, Jill Cavanaugh, Alfredo C. Castro, Karen McGovern
Supplementary Figure from Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050525c3bfe144ac014dd2f1d4357a1f
https://doi.org/10.1158/1535-7163.22523295.v1
https://doi.org/10.1158/1535-7163.22523295.v1
Autor:
Jeremy Tchaicha, Mathieu Gigoux, Alfredo C. Castro, Levi Mangarin, Luis Felipe Campesato, Taha Merghoub, Jedd D. Wolchok, Dmitriy Zamarin, Cailian Liu, Karen McGovern, Ivan J. Cohen, Sadna Budhu, Jill Cavanaugh, Stephane Pourpe, David Redmond, Roberta Zappasodi, Chien-Huan Weng, Mark G. Manfredi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The tryptophan metabolite L-Kynurenine (Kyn) interacts with the ligand-activated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d59e3ffc81c5620e9286906dd2ae745
http://link.springer.com/article/10.1038/s41467-020-17750-z
http://link.springer.com/article/10.1038/s41467-020-17750-z
Autor:
Karen McGovern, Alfredo C. Castro, Jill Cavanaugh, Silvia Coma, Meghan Walsh, Jeremy Tchaicha, Sakeena Syed, Prabitha Natarajan, Mark Manfredi, Xiaoyan M. Zhang, Jeffrey Ecsedy
Publikováno v:
Molecular cancer therapeutics. 21(8)
Aryl hydrocarbon receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells subsequent to binding to numerous endogenous and exogenous ligands. For example, AHR is activated by the metabolite kyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5472282317b508d39d9d8194eaf7a68
https://pubmed.ncbi.nlm.nih.gov/35666806
https://pubmed.ncbi.nlm.nih.gov/35666806
Autor:
Benjamin S. Amidon, Marta Sanchez-Martin, Wilmin Bartolini, Sakeena Syed, Karen McGovern, Lan Xu, Jeffrey Ecsedy, X. Michelle Zhang, Alex Constan, Alfredo C. Castro
Publikováno v:
Cancer Research. 82:2156-2156
The Hippo pathway is critical to cancer progression, biogenesis, metastasis, and therapeutic resistance. Many cancer indications have a high frequency of mutations in the Hippo pathway. These pro-tumor mutations lead to constitutive TEAD transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2442c1bb149691ab54fad1bc6fd7e0d
https://doi.org/10.1158/1538-7445.am2022-2156
https://doi.org/10.1158/1538-7445.am2022-2156
Autor:
Karen McGovern, Marta Sanchez-Martin, Jeremy H. Tchaicha, Jeff Ecsedy, Ben Amidon, X. Michelle Zhang, Alfredo C. Castro, Hyejin Frosch, Katie O'Callaghan, Sakeena Syed, Prabitha Natarajan, Jill Cavanaugh
Publikováno v:
Regular and young investigator award abstracts.
Background Aryl Hydrocarbon Receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells subsequent to binding to a diverse set of endogenous and exogenous ligands. One such endogenous AHR ligand i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ebba6efde01468121bfc712cbc9b1f8
https://doi.org/10.1136/jitc-2020-sitc2020.0448
https://doi.org/10.1136/jitc-2020-sitc2020.0448
Autor:
Christian M. Martin, Jennifer Proctor, Patrick O'Hearn, Janid A. Ali, Andre Lescarbeau, Jennifer Hoyt, Jonathan P. DiNitto, Ann M. Rowley, Thomas T. Tibbitts, Catherine A. Evans, Martin R. Tremblay, Tao Liu, Vito J. Palombella, John Soglia, Johan A. Pradeilles, Somarajan J. Nair, Melissa Pink, David G. Winkler, Stanley Goldstein, Quentin Glenadel, Erin L. O’Hearn, Culver Cheung, Erin Brophy, Alfredo C. Castro, Louis Grenier
Publikováno v:
ACS Medicinal Chemistry Letters. 7:862-867
Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f2e63c8dbb32a50d02e0a4d22c2564
https://doi.org/10.1021/acsmedchemlett.6b00238
https://doi.org/10.1021/acsmedchemlett.6b00238
Autor:
Michael Foley, Andre Lescarbeau, Martin R. Tremblay, Lombardy Richard John, Grogan Michael John, Andrew B. Hague, Kristopher M. Depew, Jimin Xiong, Joseph Helble, Priscilla L. White, Julian Adams, Brian C. Austad, Caroline D. Lory, Somarajan J. Nair, Stéphane Peluso, Lin-Chen Yu, Alfredo C. Castro, André B. Charette, Benjamin S. Lane, Jeanne Shaffer, Louis Grenier, James R. Porter, Matthew Campbell, Koney Nii O, Mark L. Behnke
Publikováno v:
Organic Process Research & Development. 20:786-798
The formation of the d-homocyclopamine ring system in IPI-926 is the key step in its semisynthesis and proceeds via a chemoselective cyclopropanation followed by a stereoselective acid-catalyzed carbocation rearrangement. In order to perform large-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9debb0b604cbda59d104def86c7642
https://doi.org/10.1021/acs.oprd.6b00048
https://doi.org/10.1021/acs.oprd.6b00048
Autor:
Sakeena Syed, Hyejin Frosch, Ben Amidon, Jill Cavanaugh, Jeffrey Ecsedy, Alfredo C. Castro, Karen McGovern, Prabitha Natarajan
Publikováno v:
Cancer Research. 80:2474-2474
The Hippo signaling cascade is an important pathway for cancer biogenesis and tumor maintenance. The Hippo pathway is heavily mutated across many cancer indications through loss of function mutations in genes such as NF2. These pro-tumor mutations le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19b866c6e65b684592e84fbe5d69a743
https://doi.org/10.1158/1538-7445.am2020-2474
https://doi.org/10.1158/1538-7445.am2020-2474