Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alfredo A. Pegoraro"'
Autor:
Alfredo A. Pegoraro, Krishnamurthy P. Gudehithlu, Jose A.L. Arruda, George Dunea, Ashok K. Singh
Publikováno v:
Kidney International. 65:2113-2122
Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments. Background In view of recent reports of large amounts of albumin fragments present in normal urine we investigated the mechanism of albumin handling b
Autor:
Alfredo A. Pegoraro, Ashok Kumar Singh, Khaja Basheerudin, George Dunea, Gogi K Singh, Krishnamurthy P. Gudehithlu, Jose A.L. Arruda, Robert B Robey
Publikováno v:
Laboratory Investigation. 84:597-606
We studied the effect of a high glucose (HG) environment on the vascular factors that are secreted by mesangial cells, and regulate endothelial growth and mesangial matrix deposition. To this effect, we measured the vascular factors in the glomeruli
Autor:
V. Khalili, Alfredo A. Pegoraro, Ramin Sam, I. Hristea, Jose A.L. Arruda, George Dunea, Mashouf Shaykh, Ashok Kumar Singh
Publikováno v:
American Journal of Nephrology. 23:438-441
Background: The clinical significance of a trace protein reading on urinalysis is unclear, and such a result is often ignored by the clinician. Methods: We examined 185 samples of urine with trace proteinuria by both Chemstrips and sulfosalicylic aci
Autor:
Ruo Hua Song, Alfredo A. Pegoraro, Ashok Kumar Singh, Rekha Singh, David J. Leehey, Nahid Alavi
Publikováno v:
Nephron Experimental Nephrology. 9:249-257
Diabetic nephropathy is characterized by accumulation of mesangial matrix. Glucose-induced inhibition of matrix-degrading enzymes such as collagenases is believed to contribute to matrix accumulation. We have previously demonstrated that 72 kDa type
Autor:
Ashok K. Singh, George Dunea, Najeeb Ranginwala, Alfredo A. Pegoraro, Mohammed Hasnain, Mashouf Shaykh, Waseem Peracha, Jose A.L. Arruda
Publikováno v:
American Journal of Kidney Diseases. 35:739-744
Urinary total protein (UTP) determinations are notoriously inaccurate, poorly reproducible, and difficult to interpret in early renal disease, causing many investigators to measure urinary albumin instead. In this study, we compare a new nonimmunolog
Publikováno v:
ASAIO Journal. 45:424-427
We reviewed the charts of 160 patients on hemodialysis and identified 33 with parathyroid hormone (PTH) > 800 pg/ml at any time during the last 3 years to confirm our impression that patients with PTH elevations for short durations of time require si
Publikováno v:
Journal of Laboratory and Clinical Medicine. 133:302-308
Carbamylated proteins formed in renal insufficiency from the spontaneous decomposition of urea exert a variety of metabolic effects. Here we examined the effects of carbamylated proteins on glomerular mesangial cells to determine whether urea retenti
Autor:
Ashok Kumar Singh, George Dunea, Ernest Cabrera, Jose A.L. Arruda, Ravi Shankar, Alfredo A. Pegoraro, Krishnamurthy P. Gudehithlu
Publikováno v:
The Journal of laboratory and clinical medicine. 139(6)
Because the mechanism by which lipoproteins are processed and modified in the renal tubule in patients with nephrosis is not completely understood, we studied the handling of low-density lipoprotein (LDL) in perfused rat kidneys made permeable by pro
Publikováno v:
Southern Medical Journal. 92:S62
Autor:
Wa Mo, Alfredo A. Pegoraro, Julienne Au, Sandra L. Garber, Jose A.L. Arruda, Ashok Kumar Singh, Carolyn Brecklin, Ruo H. Song, George Dunea
Publikováno v:
Kidney International. (1):145-153
Changes in collagenases and TGF-βbgr; precede structural alterations in a model of chronic renal fibrosis. Background To study the role of collagenases and transforming growth factor-βbgr; (TGF-βbgr;) in the genesis of interstitial fibrosis, we us