Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Alfredo A Molinolo"'
Autor:
Alfredo A Molinolo, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary C Hartman, Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Rashna Madan, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Carol A Lange, Christy R Hagan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formatio
Externí odkaz:
https://doaj.org/article/3ebc51e37c9e47cf891b9468adc3f631
Autor:
Akihiro Sakai, Mizuo Ando, Takahito Fukusumi, Shuling Ren, Chao Liu, Jesse Qualliotine, Sunny Haft, Sayed Sadat, Yuki Saito, Theresa W Guo, Guorong Xu, Roman Sasik, Kathleen M Fisch, J Silvio Gutkind, Elana J Fertig, Alfredo A Molinolo, Joseph A Califano
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233380 (2020)
Alternative mRNA splicing increases protein diversity, and alternative splicing events (ASEs) drive oncogenesis in multiple tumor types. However, the driving alterations that underlie the broad dysregulation of ASEs are incompletely defined. Using he
Externí odkaz:
https://doaj.org/article/f4066e559bd14055b02f0f7dceea5315
Autor:
Colleen L Doçi, Constantinos M Mikelis, Juan Luis Callejas-Valera, Karina K Hansen, Alfredo A Molinolo, Asuka Inoue, Stefan Offermanns, J Silvio Gutkind
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173692 (2017)
G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two members of the G protein f
Externí odkaz:
https://doaj.org/article/df420c4435414d65b2c0651af441b2d3
Autor:
Kendra A Williams, Minnkyong Lee, Ying Hu, Jonathan Andreas, Shashank J Patel, Suiyuan Zhang, Peter Chines, Abdel Elkahloun, Settara Chandrasekharappa, J Silvio Gutkind, Alfredo A Molinolo, Nigel P S Crawford
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004809 (2014)
Although prostate cancer typically runs an indolent course, a subset of men develop aggressive, fatal forms of this disease. We hypothesize that germline variation modulates susceptibility to aggressive prostate cancer. The goal of this work is to id
Externí odkaz:
https://doaj.org/article/37dcb56c93a64c16bce461847a4a366a
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61848 (2013)
Neuroendocrine (NE) differentiation has gained increased attention as a prostate cancer (PC) prognostic marker. The aim of this study is to determine whether host germline genetic variation influences tumor progression and metastasis in C57BL/6-Tg(TR
Externí odkaz:
https://doaj.org/article/98df94023eb24663a41da0fd4f7b9870
Autor:
Katiuchia Uzzun Sales, John P Hobson, Rebecca Wagenaar-Miller, Roman Szabo, Amber L Rasmussen, Alexandra Bey, Maham F Shah, Alfredo A Molinolo, Thomas H Bugge
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23261 (2011)
Genome mining at the turn of the millennium uncovered a new family of type II transmembrane serine proteases (TTSPs) that comprises 17 members in humans and 19 in mice. TTSPs phylogenetically belong to one of four subfamilies: matriptase, hepsin/TMPR
Externí odkaz:
https://doaj.org/article/e7c0670a36374c32a94c09b4c05ff719
Autor:
Jeffrey M Schafer, Diane E Peters, Thomas Morley, Shihui Liu, Alfredo A Molinolo, Stephen H Leppla, Thomas H Bugge
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20532 (2011)
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Although considerable progress has been made in elucidating the etiology of the disease, the prognosis for individuals diagnosed with HNSCC remains poor, undersc
Externí odkaz:
https://doaj.org/article/f9749c0468314d60b6c37af1e097329d
Autor:
Dina V. Hingorani, Michael M. Allevato, Maria F. Camargo, Jacqueline Lesperance, Maryam A. Quraishi, Joseph Aguilera, Ida Franiak-Pietryga, Daniel J. Scanderbeg, Zhiyong Wang, Alfredo A. Molinolo, Diego Alvarado, Andrew B. Sharabi, Jack D. Bui, Ezra E. W. Cohen, Stephen R. Adams, J. Silvio Gutkind, Sunil J. Advani
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated t
Externí odkaz:
https://doaj.org/article/72a567e57f8f44099d033840d2c36067
Autor:
James W. Hodge, Alfredo A. Molinolo, Lauren M. Lepone, Italia Grenga, Michael A. Coplin, Renee N. Donahue, Benedetto Farsaci
Effect of sunitinib or sorafenib in combination with rMVATwist- TRICOM vaccine on tumor compactness in the 4T1 breast cancer model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89344c7c628be0ca6a57049c06bce904
https://doi.org/10.1158/2326-6066.22537010.v1
https://doi.org/10.1158/2326-6066.22537010.v1
Autor:
James W. Hodge, Alfredo A. Molinolo, Lauren M. Lepone, Italia Grenga, Michael A. Coplin, Renee N. Donahue, Benedetto Farsaci
Supplementary Materials and Methods; Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e96cf5f647fb2e29a4b82b5a9ecea70
https://doi.org/10.1158/2326-6066.22537019
https://doi.org/10.1158/2326-6066.22537019