Zobrazeno 1 - 10
of 388
pro vyhledávání: '"Alfredo A Molinolo"'
Autor:
Robert Saddawi-Konefka, Aoife O’Farrell, Farhoud Faraji, Lauren Clubb, Michael M. Allevato, Shawn M. Jensen, Bryan S. Yung, Zhiyong Wang, Victoria H. Wu, Nana-Ama Anang, Riyam Al Msari, Shiruyeh Schokrpur, Ida Franiak Pietryga, Alfredo A. Molinolo, Jill P. Mesirov, Aaron B. Simon, Bernard A. Fox, Jack D. Bui, Andrew Sharabi, Ezra E. W. Cohen, Joseph A. Califano, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Response rates to immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) remain low. Here the authors show that ablative treatment of tumor-draining regional lymphatics, a standard of care approach in patien
Externí odkaz:
https://doaj.org/article/45b1c1184762403b85513f3b2ecdf50e
Autor:
Dina V. Hingorani, Michael M. Allevato, Maria F. Camargo, Jacqueline Lesperance, Maryam A. Quraishi, Joseph Aguilera, Ida Franiak-Pietryga, Daniel J. Scanderbeg, Zhiyong Wang, Alfredo A. Molinolo, Diego Alvarado, Andrew B. Sharabi, Jack D. Bui, Ezra E. W. Cohen, Stephen R. Adams, J. Silvio Gutkind, Sunil J. Advani
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated t
Externí odkaz:
https://doaj.org/article/72a567e57f8f44099d033840d2c36067
Autor:
Zhiyong Wang, Yusuke Goto, Michael M. Allevato, Victoria H. Wu, Robert Saddawi-Konefka, Mara Gilardi, Diego Alvarado, Bryan S. Yung, Aoife O’Farrell, Alfredo A. Molinolo, Umamaheswar Duvvuri, Jennifer R. Grandis, Joseph A. Califano, Ezra E. W. Cohen, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
There is an unmet need to improve the response to immune checkpoint blockade in patients with head and neck squamous cell carcinoma (HNSCC). Here the authors show that aberrant HER3 activation sustains the proliferation of PIK3CA wild type HNSCC cell
Externí odkaz:
https://doaj.org/article/5c6d1bf166824a7299c38c08b6124d71
Autor:
Yazmin San Miguel, Scarlett Lin Gomez, James D. Murphy, Richard B. Schwab, Corinne McDaniels-Davidson, Alison J. Canchola, Alfredo A. Molinolo, Jesse N. Nodora, Maria Elena Martinez
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background We assessed breast cancer mortality in older versus younger women according to race/ethnicity, neighborhood socioeconomic status (nSES), and health insurance status. Methods The study included female breast cancer cases 18 years o
Externí odkaz:
https://doaj.org/article/562ac8727757431e938ae9722d7c75ef
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
Autor:
Zhiyong Wang, Victoria H. Wu, Michael M. Allevato, Mara Gilardi, Yudou He, Juan Luis Callejas-Valera, Lynn Vitale-Cross, Daniel Martin, Panomwat Amornphimoltham, James Mcdermott, Bryan S. Yung, Yusuke Goto, Alfredo A. Molinolo, Andrew B. Sharabi, Ezra E. W. Cohen, Qianming Chen, J. Guy Lyons, Ludmil B. Alexandrov, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report
Externí odkaz:
https://doaj.org/article/3fd2a00b6d274d9893b38fa9d6f2e131
Autor:
J. Silvio Gutkind, Alfredo A. Molinolo, Xingyu Wu, Zhiyong Wang, Daniela Nachmanson, Olivier Harismendy, Ludmil B. Alexandrov, Beverly R. Wuertz, Frank G. Ondrey, Denise Laronde, Leigha D. Rock, Miriam Rosin, Charles Coffey, Valerie D. Butler, Lisa Bengtson, Chiu-Hsieh Hsu, Julie E. Bauman, Stephen M. Hewitt, Ezra E.W. Cohen, H-H. Sherry Chow, Scott M. Lippman, Eva Szabo
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the most frequently dysregulated signaling events in head and neck squamous cell carcinoma (HNSCC). Here, we conducted a single-arm, open-label phase IIa clinical trial
Externí odkaz:
https://doaj.org/article/7bd72c5d13414014a05eecb53dce3ebd
Autor:
Alfredo A Molinolo, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary C Hartman, Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Rashna Madan, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Carol A Lange, Christy R Hagan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formatio
Externí odkaz:
https://doaj.org/article/3ebc51e37c9e47cf891b9468adc3f631
Autor:
Akihiro Sakai, Mizuo Ando, Takahito Fukusumi, Shuling Ren, Chao Liu, Jesse Qualliotine, Sunny Haft, Sayed Sadat, Yuki Saito, Theresa W Guo, Guorong Xu, Roman Sasik, Kathleen M Fisch, J Silvio Gutkind, Elana J Fertig, Alfredo A Molinolo, Joseph A Califano
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233380 (2020)
Alternative mRNA splicing increases protein diversity, and alternative splicing events (ASEs) drive oncogenesis in multiple tumor types. However, the driving alterations that underlie the broad dysregulation of ASEs are incompletely defined. Using he
Externí odkaz:
https://doaj.org/article/f4066e559bd14055b02f0f7dceea5315
Autor:
Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in
Externí odkaz:
https://doaj.org/article/1b930320d9074414b8a21037b5706075
Autor:
James W. Hodge, Alfredo A. Molinolo, Lauren M. Lepone, Italia Grenga, Michael A. Coplin, Renee N. Donahue, Benedetto Farsaci
Effect of sunitinib or sorafenib in combination with rMVATwist- TRICOM vaccine on tumor compactness in the 4T1 breast cancer model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89344c7c628be0ca6a57049c06bce904
https://doi.org/10.1158/2326-6066.22537010.v1
https://doi.org/10.1158/2326-6066.22537010.v1
