Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alfreda D. Nelson"'
Autor:
Alfreda D. Nelson, Liangyu Wang, Kimberly G. Laffey, Laura R. E. Becher, Christopher A. Parks, Michele M. Hoffmann, Belinda K. Galeano, Ashutosh Mangalam, Emma Teixeiro, Tommi A. White, Adam G. Schrum, John F. Cannon, Diana Gil
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab’)2 or mAb specific for the same CD3 epitope, we observe
Externí odkaz:
https://doaj.org/article/e0c851df2d934c47ad596fb4db81592c
Autor:
Kimberly G. Laffey, Alfreda D. Nelson, Matthew J. Laffey, Quynh Nguyen, Lincoln R. Sheets, Adam G. Schrum
Publikováno v:
BMC Public Health, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background American Indian/Alaska Native (AI/AN) populations have been disproportionately affected by chronic respiratory diseases for reasons incompletely understood. Past research into disease disparity using population-based surveys mostl
Externí odkaz:
https://doaj.org/article/bf32dd295d4b4d549d3c39ab33751c9c
Autor:
Quynh Nguyen, Matthew J. Laffey, Alfreda D. Nelson, Kimberly G. Laffey, Lincoln Sheets, Adam G. Schrum
Publikováno v:
BMC Public Health, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Public Health
BMC Public Health
Background American Indian/Alaska Native (AI/AN) populations have been disproportionately affected by chronic respiratory diseases for reasons incompletely understood. Past research into disease disparity using population-based surveys mostly focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e257be6205fe7f42e8c44d3eae68698
https://doaj.org/article/bf32dd295d4b4d549d3c39ab33751c9c
https://doaj.org/article/bf32dd295d4b4d549d3c39ab33751c9c
Autor:
Hien T. Huynh, Chandrashekara Mahadevappa Puthanapura, Alfreda D Nelson, Laura RE Becher, Megan Abergel, Shuang Hu, Balbino Alarcon, Adam Schrum, Diana Gil Pages
Publikováno v:
The Journal of Immunology. 208:122.16-122.16
A cognate antigen engagement of TCR induces a conformational change in the CD3 complex (CD3Δc) that is required for productive T cell activation. CD3Δc fails when TCRs interact with poorly immunogenic antigens that do not active T cells. Anti-CD3 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc98c956c40ba979449c53cb1631de9d
https://doi.org/10.4049/jimmunol.208.supp.122.16
https://doi.org/10.4049/jimmunol.208.supp.122.16
Autor:
Hien T. Huynh, Alfreda D Nelson, Michele Hoffmann, Megan Abergel, Shuang Hu, Balbino Alarcon, Adam G Schrum, Diana Gil
Publikováno v:
The Journal of Immunology. 204:246.15-246.15
Cognate antigen binding to the T cell receptor (TCR) induces a conformational change of the CD3 complex (CD3Δc), which is required but not sufficient to trigger productive signaling from the TCR/CD3. CD3Δc fails to occur when the TCR ligates poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebe9610ebafb9135f1f058fc8ec62b5
https://doi.org/10.4049/jimmunol.204.supp.246.15
https://doi.org/10.4049/jimmunol.204.supp.246.15
Autor:
Adam G. Schrum, Hien Huynh, Svetomir N. Markovic, Shari L. Sutor, Michele M Hoffmann, Laura R. Elsbernd, Wendy K. Nevala, Larry R. Pease, Alfreda D. Nelson, Diana Gil, Christopher A. Parks
Publikováno v:
Cancer Immunology Research. 8:B78-B78
Malignant melanoma is the most aggressive form of skin cancer, accounting for 10,000 deaths annually. Largely resistant to conventional cytotoxic chemotherapy and radiation, immune checkpoint blockade (ICB) therapies have revolutionized patient care,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a6d2bb86d2c9186caa17e715e986cf
https://doi.org/10.1158/2326-6074.tumimm18-b78
https://doi.org/10.1158/2326-6074.tumimm18-b78
Publikováno v:
The Journal of Immunology. 202:68.18-68.18
Non-covalent anti-CD3 Fab dimers (Bi-Fabs) bind to the TCR/CD3 complex and activate T cells. In the presence of proper co-stimulation, anti-CD3 Bi-Fabs promote T cell cycling and acquisition of effector functions on CD4 and CD8 T cells more robustly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2682ecaa98584229490e2eed5679ca4d
https://doi.org/10.4049/jimmunol.202.supp.68.18
https://doi.org/10.4049/jimmunol.202.supp.68.18
Autor:
Diana Gil, Alfreda D. Nelson, Surendra Dasari, Christopher A. Parks, Adam G. Schrum, Michele M. Hoffmann
Publikováno v:
Journal of Biological Chemistry. 287:42936-42950
Generated by proteolytic cleavage of immunoglobulin, Fab fragments possess great promise as blocking reagents, able to bind receptors or other targets without inducing cross-linking. However, aggregation of Fab preparations is a common occurrence, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f507e78c3653fa25d3419771b828f768
https://doi.org/10.1074/jbc.m112.410217
https://doi.org/10.1074/jbc.m112.410217
Publikováno v:
Cancer Research. 78:962-962
We recently described the concept of T cell co-potentiation as means to target antigen recognition by T cells to achieve antitumor immunotherapy in mouse models. Normally, T cell antigen receptor (TCR) engagement by a strong immunogenic antigen induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97deea3b2199f4514becd562f5514010
https://doi.org/10.1158/1538-7445.am2018-962
https://doi.org/10.1158/1538-7445.am2018-962
Autor:
Carlos Molina-Mendiola, Larry R. Pease, Christopher A. Parks, Diana Gil, Govindarajan Rajagopalan, Alfreda D. Nelson, Edwin E. Reyes, Michele M. Hoffmann, Michael J. Hansen, Adam G. Schrum
Publikováno v:
Science Advances
Fab binding to CD3 couples with weak antigen recognition to enhance T cell responses and immunotherapy.
Adaptive immunity is mediated by antigen receptors that can induce weak or strong immune responses depending on the nature of the antigen tha
Adaptive immunity is mediated by antigen receptors that can induce weak or strong immune responses depending on the nature of the antigen tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1082aefedfc1e117f57d14d94c4e038
https://doi.org/10.1126/sciadv.1500415
https://doi.org/10.1126/sciadv.1500415