Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alfred Xuyang Sun"'
Autor:
Carla Bianca Luena Victorio, Wisna Novera, Arun Ganasarajah, Joanne Ong, Melisyaa Thomas, Jonas Wu, Hilary Si Yin Toh, Alfred Xuyang Sun, Eng Eong Ooi, Ann-Marie Chacko
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer affecting the adult population. Median overall survival for GBM patients is poor (15 months), primarily due to high rates of tumour recurrence and the paucity of
Externí odkaz:
https://doaj.org/article/ee0a50612b5542f497fd6d538bc211a5
Autor:
Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J. Rodriguez, Durgadevi Alagappan, Su Min Lim, Yik-Lam Cho, Yuji Shimizu, Alfred Xuyang Sun, Sheue-Houy Tyan, Edward Koo, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Katsutomo Okamura, Shuo-Chien Ling
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108152- (2023)
Summary: MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS). As fused in sarcoma (FUS) is a causal gene for ALS and regulates biogenesis of miRNAs, we syst
Externí odkaz:
https://doaj.org/article/a1a36ec90cb447b39d91b7f4cf3e5ff6
Autor:
Jonathan Aow, Tzu-Rung Huang, Yeek Teck Goh, Alfred Xuyang Sun, Gopal Thinakaran, Edward H. Koo
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112774- (2023)
Summary: Amyloid precursor protein (APP) internalization via clathrin-/dynamin-mediated endocytosis (CME) mediated by its YENPTY motif into endosomes containing β-secretase is proposed to be critical for amyloid-beta (Aβ) production. Here, we show
Externí odkaz:
https://doaj.org/article/1ad08fec10ba44458bddca6059c7e346
Autor:
Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Yixin Xiao, Danlei Wang, Audrey Tze Ting Khoo, Levena Sani, Hoang-Dai Tran, Paul Kim, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Bing Lim, Hyunsoo Shawn Je
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1942-1953 (2016)
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders. Patient-derived interneurons could provide a foundation for studying the pathogenesis o
Externí odkaz:
https://doaj.org/article/091f2fb94fb34db09bbe7c3f12c0d72b
Autor:
Alfred Xuyang Sun1,2 sunxya@gis.a-star.edu.sg, Qiang Yuan3,4, Masahiro Fukuda4, Weonjin Yu4, Haidun Yan5, Grace Gui Yin Lim1, Mui Hoon Nai6, D’Agostino, Giuseppe Alessandro7, Hoang-Dai Tran2, Yoko Itahana8, Danlei Wang1, Lokman, Hidayat4, Itahana, Koji8, Wai Lin Lim, Stephanie4, Jiong Tang9, Ya Yin Chang1, Menglan Zhang4, Cook, Stuart A.7, Rackham, Owen J. L.7, Chwee Teck Lim6
Publikováno v:
Science. 12/20/2019, Vol. 366 Issue 6472, p1486-1492. 7p. 4 Diagrams.
Autor:
Lynn Yap, Shang Li, Yu Ming Lim, Xin Yi Choo, Lusy Handoko, Alfred Xuyang Sun, Owen J. L. Rackham, John F. Ouyang, Khairunnisa Katwadi, Karl Tryggvason
Publikováno v:
ACS Synthetic Biology. 10:640-645
The combination of single-cell RNA sequencing with CRISPR inhibition/activation provides a high-throughput approach to simultaneously study the effects of hundreds if not thousands of gene perturbations in a single experiment. One recent development
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Publikováno v:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
Neuropsychiatric manifestations of coronavirus disease 2019 (COVID-19) have been increasingly recognized. However, the pathophysiology of COVID-19 in the central nervous system remains unclear. Brain organoid models derived from human pluripotent ste
Autor:
Paul M. Yen, Brijesh K. Singh, Eyleen L. K. Goh, Danlei Wang, Jin Zhou, Dongrui Ma, Jinyan Zhang, Yi Zhao, Eng-King Tan, Dongliang Ma, Hoang-Dai Tran, Alfred Xuyang Sun, Wei Zhou
Publikováno v:
Human Molecular Genetics
Coiled-coil-helix-coiled-coil-helix domain containing protein 2 (CHCHD2) mutations were linked with autosomal dominant Parkinson’s disease (PD) and recently, Alzheimer’s disease/frontotemporal dementia. In the current study, we generated isogenic