Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alfred W. Alberts"'
Publikováno v:
Biochemical Journal. 289:889-895
The beta-lactones L-659,699 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2- oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid) and its radioactive derivative 3H-L-668,411 (the 2,3-ditritiated methyl ester of L-659,699) inhibited a partially purified preparation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cef03008eb1781c072e8fceacf8ca98
https://doi.org/10.1042/bj2890889
https://doi.org/10.1042/bj2890889
Autor:
Thomas W. Doebber, Alfred W. Alberts, San-Bao Hwang, Robert L. Bugianesi, My-Hanh Lam, Margaret Wu, John C. Chabala, William H. Parsons, Mitree M. Ponpipom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:181-184
(±)-trans-2-(3-Methoxy-4-phenylsulfonylethoxy-5-n-propylsulfonylphenyl)tetrahydrofuran (L-671,284) is a highly potent, selective, competitive PAF-receptor antagonist with a Ki of 1.0 nM for inhibition of binding of [3H]C18-PAF to human platelets and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae90938d643d8bd7e4b4b38235478a32
https://doi.org/10.1016/s0960-894x(01)80446-7
https://doi.org/10.1016/s0960-894x(01)80446-7
Autor:
Ludvic Peric-Golia, Dana E. Wilson, Linda K Kwong, Kenneth R. Feingold, Alfred W. Alberts, Thanh Le, John D. Karkas
Publikováno v:
Diabetes. 40:1630-1639
We previously reported that dog diabetes results in hypercholesterolemia and the accumulation of a high-density lipoprotein (HDL) subclass, HDL1. Hypercholesterolemic diabetic rodents exhibit hyperphagia, intestinal hypertrophy, and increased intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783296372f6496c5d8408d2a32581372
https://doi.org/10.2337/diab.40.12.1630
https://doi.org/10.2337/diab.40.12.1630
Autor:
J. S. Chen, John D. Karkas, Vincent M. Hunt, Alfred W. Alberts, Y. Chao, R. Liou, G. W. Kuron
Publikováno v:
European Journal of Clinical Pharmacology. 40:S11-S14
Lovastatin and simvastatin are potent competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Key inhibit the synthesis of cholesterol in cultured HepG23 cells, rat hepatocytes and in rats. The primary target organ of cholesterol s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1680d8c6b5679b8c5075a199e4481d68
https://doi.org/10.1007/bf01409400
https://doi.org/10.1007/bf01409400
Autor:
Narindar N. Girotra, Tesfaye Biftu, Donald W. Graham, Silvi Luell, Robert L. Bugianesi, Chan-Hwa Kuo, D. Euan MacIntyre, Soumya P. Sahoo, My-Hanh Lam, John C. Chabala, Alfred W. Alberts, Mitree M. Ponpipom, Margaret Wu, Thomas W. Doebber, John J. Acton, Roger Meurer, T. Bach, San-Bao Hwang, Philip Davies
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:327-332
An enantioselective synthesis of MK 287 (L-680,573), a member of a family of trans-,5-diaryltetrahydrofurans, and its biological activity are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1223c05c5b6f17c5d39398372d13dde9
https://doi.org/10.1016/s0960-894x(01)80818-0
https://doi.org/10.1016/s0960-894x(01)80818-0
Autor:
Jeremy M. Gleeson, Dana E. Wilson, Thanh Le, Alfred W. Alberts, Ing-Fong Chan, Jamal S. Hejazi, Linda K. Kwong
Publikováno v:
Atherosclerosis. 84:1-12
Hypercholesterolemia and increased concentrations of an apolipoprotein E (apoE)-containing HDL subclass, high density lipoprotein 1 (HDL 1 ) have been observed in streptozocin-alloxan diabetic dogs consuming normal amounts of dietary cholesterol. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b68f488490df523db7bb0d08190a6e3
https://doi.org/10.1016/0021-9150(90)90002-z
https://doi.org/10.1016/0021-9150(90)90002-z
Autor:
Alfred W. Alberts
Publikováno v:
Drug Investigation. 2:9-17
Lovastatin (mevinolin) and simvastatin (epistatin) are lactone prodrugs, which, after conversion to their respective dihydroxy open acids, are very active inhibitors of HMG CoA reductase, the key rate-limiting enzyme in cholesterol biosynthesis. Afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322bd4b8d36ee2d5eb67db22750d6a9a
https://doi.org/10.1007/bf03258189
https://doi.org/10.1007/bf03258189
Autor:
Alfred W. Alberts, Robert L. Bugianesi, Bach Tn, John J. Acton, Mitree M. Ponpipom, John C. Chabala, William H. Parsons, Tesfaye Biftu, Nirindar N Girotra, Ball Rg
Publikováno v:
Journal of medicinal chemistry. 35(19)
(-)-trans-(2S,5S)-2-[3-[(2-Oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (10) is one of the most potent platelet-activating factor (PAF) antagonists in vitro and in vivo developed to date. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99b510f457609d4aa2b7c1c5acd41e2
https://pubmed.ncbi.nlm.nih.gov/1404229
https://pubmed.ncbi.nlm.nih.gov/1404229
Publikováno v:
Lipids. 26(12)
Addition of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to leukocyte-rich plasma from several species resulted in the rapid and pronounced activation of the PAF biosynthetic enzyme acetyl-CoA:1-O-alkyl-sn-glycero-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127a698c29d414813e793fc9c5b8e08d
https://pubmed.ncbi.nlm.nih.gov/1819756
https://pubmed.ncbi.nlm.nih.gov/1819756
Autor:
Alfred W. Alberts
Publikováno v:
Cardiology. 77
The microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase is a key rate-controlling step early in the cholesterol biosynthetic pathway that catalyzes the conversion of HMG CoA to mevalonic acid. Since this enzyme plays a signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d53248a865c7a36b77337db9a6f2f2
https://pubmed.ncbi.nlm.nih.gov/2073667
https://pubmed.ncbi.nlm.nih.gov/2073667