Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alfred W. A. Hahn"'
Autor:
Alfred W. A. Hahn, Manfred Raschack, Alwin Weber, Silvia Göck, Stefan Hergenröder, Roef Jansen, Willi Amberg, Liliane Unger, Peter Alken
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:S241-S244
LU 302 872 (racemate LU 224 332) is a new glycerinic acid derivative related to the selective ET A receptor antagonist LU 135 252. LU 302 872 exhibits high and balanced affinity to ET A and ET B receptors (K i 2.2 and 5.8 nmol/L), whereas LU 135 252
Publikováno v:
Journal of Vascular Research. 32:162-174
The arterial tenascin C expression in vivo and in vitro has been studied using immunohistochemistry. The functional relevance of localized tenascin C expression was assessed in vitro using various human cell types involved in the progression of vascu
Autor:
Konstantin G. Birukov, Vsevolod A. Tkachuk, V.P. Shirinsky, Olga V. Stepanova, Vladimir N. Smirnov, Terese J. Resink, Alfred W. A. Hahn
Publikováno v:
Molecular and Cellular Biochemistry. 144:131-139
The exertion of periodic dynamic strain on the arterial wall is hypothesized to be relevant to smooth muscle cell morphology and function. This study has investigated the effect of cyclic mechanical stretching on rabbit aortic smooth muscle cell prol
Publikováno v:
Journal of Vascular Research. 31:163-172
Laminin, a major structural glycoprotein complex of basement membranes has been found to be modulated by angiotensin II in vitro and in vivo. In cultures of aortic organoids and vascular smooth muscle cells, expression of laminin was stimulated by ex
Autor:
Valery N. Bochkov, Fritz R. Bühler, Alfred W. A. Hahn, Thérèse J. Resink, Vsevolod A. Tkachuk, J. Bernhardt
Publikováno v:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 13:1261-1269
Low-density (LDL) and high-density (HDL3) lipoproteins dose-dependently activate phosphoinositide turnover and elevate cytosolic free Ca2+ concentrations ([Ca2+]i) in cultured vascular smooth muscle cells (VSMCs) from either human (microarterioles an
Publikováno v:
Biochemical and Biophysical Research Communications. 192:1260-1265
Angiotensin II is a major regulator of cardiovascular function, fluid homeostasis and also plays a role in long-term cardiovascular disease processes. At present it is unclear if and how the diverse functions of angiotensin II may relate to different
Publikováno v:
Biochemical and Biophysical Research Communications. 192:189-197
This study has investigated the influence of the vasoconstrictor peptides angiotensin II (Ang II) and endothelin-1 (ET-1) on fibronectin expression by vascular smooth muscle cells (VSMC). In confluent, quiescent cultures of VSMC, Ang II and ET-1 elev
Publikováno v:
Journal of Cardiovascular Pharmacology. 20:S55-S64
Publikováno v:
Journal of Cardiovascular Pharmacology. 20:S33-S36
Endothelin-1 (ET-1) produced by vascular endothelial cells has been proposed to act in a paracrine manner on adjacent smooth muscle cells (SMCs) in vivo, exerting a variety of short- and long-term effects. Although some of the in vitro ET-1-mediated
Publikováno v:
American Journal of Hypertension. 4:183-188
Smooth muscle cells from spontaneously hypertensive rats (SHR) proliferate in culture faster than those isolated from sex- and age-matched Wistar- Kyoto (WKY) animals. There was no difference in the kinetics of S6 kinase activation in the two culture