Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alfred T. Welzel"'
Autor:
Monichan Phay, Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Veronika Blinder, Tiernan T O'Malley, Alan Solomon, Dominic M Walsh, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)
Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi
Externí odkaz:
https://doaj.org/article/d9c973e149054991ba50bef3823c4302
Autor:
Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50317 (2012)
Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer's disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precis
Externí odkaz:
https://doaj.org/article/b5e5d024a32647f4acc8c5e30db8eff6
Autor:
Dennis J. Selkoe, Igor Klyubin, Dominic M. Walsh, Peter A. Seubert, Alfred T. Welzel, Michael J. Rowan, Beth L. Ostaszewski, John E. Maggio, Shaomin Li, Donald Walker, Ganesh M. Shankar
Publikováno v:
Biochemistry
Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents. The “amyloid hypothesis” of AD postulates deleterious effects of small, soluble forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db75fea61a144b8adb1fd2c73dfb67d
http://europepmc.org/articles/PMC4070750
http://europepmc.org/articles/PMC4070750
Autor:
Richard K. Dykoski, Andrew E. Barry, James P. Cleary, Jessica M. Mc Donald, Michael J. Rowan, Martijn F.B.G. Gebbink, James S. Foster, Dominic M. Walsh, Alfred T. Welzel, Brian O'Nuallain, Igor Klyubin
Publikováno v:
Journal of Neurochemistry. 119:189-201
Diverse lines of evidence indicate that pre-fibrillar, diffusible assemblies of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease pathogenesis. Although the precise molecular identity of these soluble toxins remains unsettled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2de65de5813d78d665a6524fa918af9f
https://doi.org/10.1111/j.1471-4159.2011.07389.x
https://doi.org/10.1111/j.1471-4159.2011.07389.x
Autor:
George M. Savva, Carol Brayne, G. Forster, Paul G. Ince, Dennis J. Selkoe, Alfred T. Welzel, Dominic M. Walsh, Jessica M. Mc Donald, Ganesh M. Shankar
Publikováno v:
Brain; Vol 133
The molecular pathways leading to Alzheimer-type dementia are not well understood, but the amyloid beta-protein is believed to be centrally involved. The quantity of amyloid beta-protein containing plaques does not correlate well with clinical status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34d954471bfe7a5332f0a9c3b77dbb3
https://doi.org/10.1093/brain/awq065
https://doi.org/10.1093/brain/awq065
Autor:
Thomas B. Ladd, Bernadette Cusack, Debra Yager, Dominic M. Walsh, Thomas Kukar, Ghulam M. Maharvi, Robert Chapman, Alfred T. Welzel, Vijayaraghavan Rangachari, Christopher B. Eckman, Wenjuan Ye, Christophe Verbeeck, Sarah A. Sagi, Maralyssa Bann, Todd E. Golde, Robert W. Price, Terrone L. Rosenberry, Boris Schmidt, Justin W. Torpey, Brent Healy, Barbara A. Cottrell, Karen Jansen-West, Jason L. Eriksen, Edward H. Koo, Abdul H. Fauq, Patrick C. Fraering, Rajeshwar Narlawar, Michael S. Wolfe, Brenda D. Moore
Publikováno v:
Nature. 453:925-929
Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf54ddc8ee902f121fabb607fd45858
https://doi.org/10.1038/nature07055
https://doi.org/10.1038/nature07055
Autor:
Roger Anwyl, Ying Peng, Thomas Wisniewski, William K. Cullen, Alfred T. Welzel, Michael J. Rowan, Henrik Zetterberg, Dennis J. Selkoe, Dominic M. Walsh, Igor Klyubin, Kaj Blennow, Cynthia A. Lemere, Vicki Betts, Anders Wallin
Publikováno v:
The Journal of Neuroscience. 28:4231-4237
The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid β protein (Aβ) can be targeted in a similar manner to animal cell-derived or synthetic Aβ. Because the structure of Aβ depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a6ffe4274bcb426644e5eff0bea4c7
https://doi.org/10.1523/jneurosci.5161-07.2008
https://doi.org/10.1523/jneurosci.5161-07.2008
Autor:
Tiernan T. O'Malley, Brian O'Nuallain, Veronika Blinder, Helen P. McWilliams-Koeppen, Dominic M. Walsh, Monichan Phay, Angela Williams, Alan Solomon, Alfred T. Welzel
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)
PLoS ONE
PLoS ONE
Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d067687aad6c2989e54bd015bf6a829c
http://europepmc.org/articles/PMC4569075?pdf=render
http://europepmc.org/articles/PMC4569075?pdf=render
Autor:
Dominic M. Walsh, Susan Byrne, Jean Paul G. Vonsattel, Orla Hardiman, Lewis P. Rowland, Alfred T. Welzel
Publikováno v:
Neurodegenerative Disorders ISBN: 9781849960106
Neurodegenerative diseases share a number of common features with respect to clinical course, pathology, and molecular mechanisms. This chapter outlines the common themes of neurodegeneration, including the concept of selective neuronal vulnerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa779e7e58f1f63cd68caa1cdcf8dce
https://doi.org/10.1007/978-1-84996-011-3_1
https://doi.org/10.1007/978-1-84996-011-3_1
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 670
Recent data suggest that soluble, non-fibrillar assemblies of the amyloid β-protein (Aβ) may mediate the synaptic deficits that characterize the early stages of Alzheimer's disease. Consequently, much effort has been expended in isolating and study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9ebf5141cd6773321e2c5e1ad79d48f
https://pubmed.ncbi.nlm.nih.gov/20967581
https://pubmed.ncbi.nlm.nih.gov/20967581