Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alfred T. Elvin"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 12:515-523
Multiple oral doses of diltiazem (DTZ) and propranolol (PPL, 60 mg every 8 h daily for 13 doses) were administered to 14 healthy volunteers alone and in combination on three separate occasions. Serial blood samples were collected up to 24 h after dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82b14f27b89f5d03952a04b9f60f423
https://doi.org/10.1002/bdd.2510120705
https://doi.org/10.1002/bdd.2510120705
Autor:
Robert C. Lanman, Bruce Morrill, Dennis H. Giesing, Michael B Lanman, Dale K Yu, Larry S Eichmeier, Alfred T Elvin
Publikováno v:
Clinical Pharmacology and Therapeutics. 48:26-33
Single doses of 1 gm 5-aminosalicylic acid (5-ASA) suspension was administered to 24 healthy volunteers during both fasting and fed conditions. For subjects in a fasting state, plasma 5-ASA and acetyl 5-ASA concentrations peaked rapidly 1 hour after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27a7fab66e6254cf318a2af25ccaddb
https://doi.org/10.1038/clpt.1990.113
https://doi.org/10.1038/clpt.1990.113
Publikováno v:
Clinical Pharmacology & Therapeutics. 19:757-766
Tocainide, a primary amine analogue of lidocaine, is effective against some experimental and clinical arrhythmias. Its pharmacokinetic behavior was studied in 6 healthy male subjects. Peak blood levels (CB max) and area under the blood concentration-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7f291d033b1c72e667141d1209c358
https://doi.org/10.1002/cpt1976196757
https://doi.org/10.1002/cpt1976196757
Publikováno v:
Clinical Pharmacology & Therapeutics. 25:172-183
Five healthy male subjects received oral doses of 10 and 40 mg/kg of sulfamethazine (SMZ) approximately 14 days apart in a nonrandomized crossover study. Blood and urine samples were collected for at least 24 and 72 hr, respectively. All samples were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b132b60f6590cd25bf273b6d4a8f8cb1
https://doi.org/10.1002/cpt1979252172
https://doi.org/10.1002/cpt1979252172
Publikováno v:
Clinical Pharmacology and Therapeutics. 30:455-460
The effect of high-protein meal on the hepatic clearance (ClH) of intravenous lidocaine, because of its conceptual importance in understanding first-pass metabolic phenomena, was evaluated in nine healthy males. Our randomized crossover study demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac5a76ce5eaa49ac6f172c76e25b606
https://doi.org/10.1038/clpt.1981.188
https://doi.org/10.1038/clpt.1981.188
Publikováno v:
Journal of Pharmaceutical Sciences. 71:1011-1014
The metabolism of the antiarrhythmic drug tocainide (I) has been shown previously to occur via a novel pathway involving the addition of carbon dioxide to the primary amine nitrogen of I followed by conjugation with glucuronic acid. The product of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b32ccc39d0570ae0f23958bd18133d
https://doi.org/10.1002/jps.2600710914
https://doi.org/10.1002/jps.2600710914
Publikováno v:
Inorganic Chemistry. 13:2031-2033
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba19061ea91d5ab91394806fa91d91a3
https://doi.org/10.1021/ic50138a048
https://doi.org/10.1021/ic50138a048
Autor:
K.S. Albert, Alfred T. Elvin, Edward J. Antal, W R Gillespie, John G. Wagner, Evelyn A. Pratt
Publikováno v:
Biopharmaceutics & Drug Disposition. 6:341-343
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f516cb1e7507a37b0deba41f1d567f
https://doi.org/10.1002/bdd.2510060309
https://doi.org/10.1002/bdd.2510060309
Publikováno v:
Journal of Pharmaceutical Sciences. 73:1791-1793
Tris(2-butoxyethyl) phosphate (I), a plasticizer commonly found in evacuated blood collection tubes, displaces many basic drugs from their binding sites on serum proteins and causes them to redistribute from serum into red blood cells (i.e., artifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118a041650dc000e2d86013fa87a4941
https://doi.org/10.1002/jps.2600731233
https://doi.org/10.1002/jps.2600731233
Publikováno v:
Chemischer Informationsdienst. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::519ec837ef2f4431cc8f12293e3399bf
https://doi.org/10.1002/chin.197440344
https://doi.org/10.1002/chin.197440344