Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alfred T Harding"'
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008098 (2019)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting virion incompletely infectious. It is kn
Externí odkaz:
https://doaj.org/article/e46eed4b7dda409aba017274b569886d
Autor:
Alfred T. Harding, Karen Ocwieja, Minjin Jeong, Yichen Zhang, Valerie Leger, Nairuti Jhala, Konstantina M. Stankovic, Lee Gehrke
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTCongenital hearing loss is a common chronic condition affecting children in both developed and developing nations. Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes congen
Externí odkaz:
https://doaj.org/article/d952475ee8e2487e8275ecf2a527d2d4
Autor:
Brook E. Heaton, Edward M. Kennedy, Rebekah E. Dumm, Alfred T. Harding, Matthew T. Sacco, David Sachs, Nicholas S. Heaton
Publikováno v:
Cell Reports, Vol 20, Iss 7, Pp 1503-1512 (2017)
Influenza A virus (IAV) is a pathogen that poses significant risks to human health. It is therefore critical to develop strategies to prevent influenza disease. Many loss-of-function screens have been performed to identify the host proteins required
Externí odkaz:
https://doaj.org/article/e716c767ea214b789a87a430cce058b3
Autor:
Benjamin H, Schott, Liuyang, Wang, Xinyu, Zhu, Alfred T, Harding, Emily R, Ko, Jeffrey S, Bourgeois, Erica J, Washington, Thomas W, Burke, Jack, Anderson, Emma, Bergstrom, Zoe, Gardener, Suzanna, Paterson, Richard G, Brennan, Christopher, Chiu, Micah T, McClain, Christopher W, Woods, Simon G, Gregory, Nicholas S, Heaton, Dennis C, Ko
Publikováno v:
Cell genomics. 2(11)
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::375f0e4e6f2c25d65219308a87b43d6b
https://pubmed.ncbi.nlm.nih.gov/36465279
https://pubmed.ncbi.nlm.nih.gov/36465279
Autor:
Benjamin H. Schott, Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, Thomas W. Burke, Jack Anderson, Emma Bergstrom, Zoe Gardener, Suzanna Paterson, Richard G. Brennan, Christopher Chiu, Micah T. McClain, Christopher W. Woods, Simon G. Gregory, Nicholas S. Heaton, Dennis C. Ko
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ba3d18cfb5edf87a1e40e2fbe068b3
http://hdl.handle.net/10044/1/100790
http://hdl.handle.net/10044/1/100790
Autor:
Tomer M. Yaron, Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M. Liberatore, Danielle K. Bulaon, Samantha J. Van Nest, Nikos Koundouros, Edward R. Kastenhuber, Marisa N. Mercadante, Kripa Shobana-Ganesh, Long He, Robert E. Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E. Nilsson-Payant, Gina Lee, Joseph D. Trimarco, Kaitlyn N. Burke, Cait E. Hamele, Ryan R. Chaparian, Alfred T. Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M. Smith, Anthony P. Possemato, Sasha L. Tkachev, Peter V. Hornbeck, Sean A. Beausoleil, Shankara K. Anand, François Aguet, Gad Getz, Andrew D. Davidson, Kate Heesom, Maia Kavanagh-Williamson, David A. Matthews, Benjamin R. tenOever, Lewis C. Cantley, John Blenis, Nicholas S. Heaton
Publikováno v:
Science signaling, vol 15, iss 757
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f52febef82f67d02ed9c0d55e48f84
https://escholarship.org/uc/item/44d513nc
https://escholarship.org/uc/item/44d513nc
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. To facilitate cost-effective growth, vaccine strains are serially passaged under production conditio
Externí odkaz:
https://doaj.org/article/903553c0d64a420585785726adc1a281
Autor:
Ryan R. Chaparian, Alfred T. Harding, Cait E. Hamele, Kristina Riebe, Amelia Karlsson, Gregory D. Sempowski, Nicholas S. Heaton, Brook E. Heaton
Publikováno v:
Journal of Virology. 96
Vaccines targeting SARS-CoV-2 have been shown to be highly effective; however, the breadth against emerging variants and the longevity of protection remains unclear. Postimmunization boosting has been shown to be beneficial for disease protection, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e6edee6214b02f85e345c646115b8f
https://doi.org/10.1128/jvi.00689-22
https://doi.org/10.1128/jvi.00689-22
Publikováno v:
Science
GPER1 in utero to the rescue! Several common pathogens, including influenza A virus (IAV), can activate systemic type I interferon (IFN) signaling during pregnancy. Such infections would be expected to cause birth defects and fetal mortality, but mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef454472f85452a55d12de70a101e609
https://doi.org/10.1126/science.aba9001
https://doi.org/10.1126/science.aba9001
Autor:
Benjamin H. Schott, Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, Thomas W. Burke, Jack Anderson, Emma Bergstrom, Zoe Gardener, Suzanna Paterson, Richard G. Brennan, Christopher Chiu, Micah T. McClain, Christopher W. Woods, Simon G. Gregory, Nicholas S. Heaton, Dennis C. Ko
SummaryDiversity in the human genome is one factor that confers resistance and susceptibility to infectious diseases. This is observed most dramatically during pandemics, where individuals exhibit large differences in risk and clinical outcomes again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f3d505c6414d2fc1557705d16e6647
https://doi.org/10.1101/2022.01.30.478319
https://doi.org/10.1101/2022.01.30.478319