Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Alfred Sze Lok, Cheng"'
Autor:
Xiaoyu Liu, Man Liu, Haoran Wu, Wenshu Tang, Weiqin Yang, Thomas T.H. Chan, Lingyun Zhang, Shufen Chen, Zhewen Xiong, Jianxin Liang, Willis Wai-Yiu Si-Tou, Ting Shu, Jingqing Li, Jianquan Cao, Chengpeng Zhong, Hanyong Sun, Tsz Tung Kwong, Howard H.W. Leung, John Wong, Paul Bo-San Lai, Ka-Fai To, Tingxiu Xiang, Joseph Jao-Yiu Sung, Stephen Lam Chan, Jingying Zhou, Alfred Sze-Lok Cheng
Publikováno v:
JHEP Reports, Vol 6, Iss 7, Pp 101087- (2024)
Background & Aims: Recent studies demonstrated the importance of fibrosis in promoting an immunosuppressive liver microenvironment and thereby aggressive hepatocellular carcinoma (HCC) growth and resistance to immune checkpoint blockade (ICB), partic
Externí odkaz:
https://doaj.org/article/548a0fa4c9c849b8b8cb170ca38dbeaf
Autor:
Jingying Zhou, Huanyu Wang, Ting Shu, Jing Wang, Weiqin Yang, Jingqing Li, Lipeng Ding, Man Liu, Hanyong Sun, John Wong, Paul Bo-san Lai, Shun-Wa Tsang, Simon E. Ward, King-Lau Chow, Joseph Jao-yiu Sung, Alfred Sze-Lok Cheng
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107626- (2023)
Summary: Massive expansion of immature and suppressive myeloid cells is a common feature of malignant solid tumors. Over-expression of cyclin-dependent kinase 20, also known as cell cycle-related kinase (CCRK), in hepatocellular carcinoma (HCC) corre
Externí odkaz:
https://doaj.org/article/64467f2d4d01480781df060e9f589903
Autor:
Kwan Yeung Wong, Gareth J. Morgan, Eileen M. Boyle, Alfred Sze Lok Cheng, Kevin Yuk-Lap Yip, Chor Sang Chim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Enhancer DNA methylation and expression of MYBPHL was studied in multiple myeloma (MM). By bisulfite genomic sequencing, among the three CpGs inside the MYBPHL enhancer, CpG1 was significantly hypomethylated in MM cell lines (6.7–50.0%) th
Externí odkaz:
https://doaj.org/article/d58c3083d67245f89af33385adaad2f0
Autor:
Philip Chiu‐Tsun Tang, Jeff Yat‐Fai Chung, Vivian Wei‐wen Xue, Jun Xiao, Xiao‐Ming Meng, Xiao‐Ru Huang, Shuang Zhou, Alex Siu‐Wing Chan, Anna Chi‐Man Tsang, Alfred Sze‐Lok Cheng, Tin‐Lap Lee, Kam‐Tong Leung, Eric W.‐F. Lam, Ka‐Fai To, Patrick Ming‐Kuen Tang, Hui‐Yao Lan
Publikováno v:
Advanced Science, Vol 9, Iss 1, Pp n/a-n/a (2022)
Abstract Cancer‐associated fibroblasts (CAFs) are important in tumor microenvironment (TME) driven cancer progression. However, CAFs are heterogeneous and still largely underdefined, better understanding their origins will identify new therapeutic
Externí odkaz:
https://doaj.org/article/88a2b3b2105e4c93a1fe6c6dfeb41b23
Autor:
Tsz Tung Kwong, Chi Hang Wong, Jing Ying Zhou, Alfred Sze Lok Cheng, Joseph Jao Yiu Sung, Anthony Wing Hung Chan, Stephen Lam Chan
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100224- (2021)
Background & aims: Immune checkpoint blockade (ICB) has been approved for treatment of hepatocellular carcinoma (HCC). However, many patients with advanced HCC are non-responders to ICB monotherapy. Cytotoxic chemotherapy has been proposed to modulat
Externí odkaz:
https://doaj.org/article/a6f98b12474d47d587e8081f2e31470b
Autor:
Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng
Publikováno v:
Molecular Therapy. 31:119-133
The local microenvironment where tumors develop can shape cancer progression and therapeutic outcome. Emerging evidence demonstrate that the efficacy of immune-checkpoint blockade (ICB) is undermined by fibrotic tumor microenvironment (TME). The majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6053fa210c7ac27584ac1c0a87e5dbc3
https://doi.org/10.1016/j.ymthe.2022.09.012
https://doi.org/10.1016/j.ymthe.2022.09.012
Autor:
Ping Sun, Jing Wang, Khadija S. Khan, Weiqin Yang, Billy Wai-Lung Ng, Nikita Ilment, Matthes Zessin, Emre F. Bülbül, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Publikováno v:
Journal of Medicinal Chemistry. 65:16313-16337
Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition of HDAC8 overexpressed in various of cancers reduces hepatocellular carcinoma tumorigenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c985e4087f311b0e6b58dd9531d9764
https://doi.org/10.1021/acs.jmedchem.2c01132
https://doi.org/10.1021/acs.jmedchem.2c01132
Autor:
Xinjie Zhu, Qiang Zhang, Eric Dun Ho, Ken Hung-On Yu, Chris Liu, Tim H. Huang, Alfred Sze-Lok Cheng, Ben Kao, Eric Lo, Kevin Y. Yip
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background A genomic signal track is a set of genomic intervals associated with values of various types, such as measurements from high-throughput experiments. Analysis of signal tracks requires complex computational methods, which often mak
Externí odkaz:
https://doaj.org/article/57b609a486fd4677a99168b5154b364e
Autor:
Xuezhen, Zeng, Guanrui, Liao, Shumin, Li, Haining, Liu, Xiao, Zhao, Shuang, Li, Kai, Lei, Shenghua, Zhu, Zhihang, Chen, Yi, Zhao, Xuxin, Ren, Tianhong, Su, Alfred Sze-Lok, Cheng, Sui, Peng, Shuibin, Lin, Ji, Wang, Shuling, Chen, Ming, Kuang
Publikováno v:
Hepatology. 77:1122-1138
Radiofrequency ablation (RFA) is an important curative therapy in hepatocellular carcinoma (HCC), but recurrence rate remains as high as all the other HCC therapeutic modalities. Methyltransferase 1 (METTL1), an enzyme for mBy immunohistochemistry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1371dd25b36f20c880e193a19588536f
https://doi.org/10.1002/hep.32585
https://doi.org/10.1002/hep.32585
Autor:
Hung Chan, Qing Li, Xiansong Wang, Wing Yingzhi Liu, Wei Hu, Judeng Zeng, Chuan Xie, Thomas Ngai Yeung Kwong, Idy Hiu Ting Ho, Xiaodong Liu, Huarong Chen, Jun Yu, Ho Ko, Raphael Chiu Yeung Chan, Margaret Ip, Tony Gin, Alfred Sze Lok Cheng, Lin Zhang, Matthew Tak Vai Chan, Sunny Hei Wong, William Ka Kei Wu
Publikováno v:
Autophagy. 18:2050-2067
Clostridioides difficile infection (CDI) is a common cause of nosocomial diarrhea. TcdB is a major C. difficile exotoxin that activates macrophages to promote inflammation and epithelial damage. Lysosome impairment is a known trigger for inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721c18a4ac7c1fb9b149bb18003a3db9
https://doi.org/10.1080/15548627.2021.2016004
https://doi.org/10.1080/15548627.2021.2016004