Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Alfred Singer"'
Autor:
Xuguang Tai, Alfred Singer
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 2, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/6ce5d04c3b6e46c5b7f62bcf03a46b23
Autor:
François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is ref
Externí odkaz:
https://doaj.org/article/76e87e0eec1242be99fc58fb598e83f1
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
Motoko Y. Kimura, Akemi Igi, Koji Hayashizaki, Yukiyoshi Mita, Miho Shinzawa, Tejas Kadakia, Yukihiro Endo, Satomi Ogawa, Ryoji Yagi, Shinichiro Motohashi, Alfred Singer, Toshinori Nakayama
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
CD69 competes with S1P1, a chemokine receptor mediating thymocyte egress, for surface expression on thymocytes, but whether CD69 is required for normal thymic development is unclear. Here the authors show that CD69 and S1P1 synergize to control type
Externí odkaz:
https://doaj.org/article/610ec23ec8e14597aab0581e48fe6d35
Autor:
Anne Gegonne, Qing-Rong Chen, Anup Dey, Ruth Etzensperger, Xuguang Tai, Alfred Singer, Daoud Meerzaman, Keiko Ozato, Dinah S. Singer
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 117-129 (2018)
Summary: T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly dist
Externí odkaz:
https://doaj.org/article/69f3e19e9a5c4397a55ab00523c4b6eb
Autor:
Asaf Madi, Asaf Poran, Eric Shifrut, Shlomit Reich-Zeliger, Erez Greenstein, Irena Zaretsky, Tomer Arnon, Francois Van Laethem, Alfred Singer, Jinghua Lu, Peter D Sun, Irun R Cohen, Nir Friedman
Publikováno v:
eLife, Vol 6 (2017)
Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between species has not been characterized. Using n
Externí odkaz:
https://doaj.org/article/3937974f5c114e8194e5e132044691d1
Autor:
Xuguang Tai, Alyssa Indart, Mirelle Rojano, Jie Guo, Nicolai Apenes, Tejas Kadakia, Marco Craveiro, Amala Alag, Ruth Etzensperger, Mohamed Elsherif Badr, Flora Zhang, Zhongmei Zhang, Jie Mu, Terry Guinter, Assiatu Crossman, Larry Granger, Susan Sharrow, Xuyu Zhou, Alfred Singer
Publikováno v:
Nature Immunology. 24:637-651
Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to differentiate into specialized regulatory T (Treg) or effector T (Teff) CD4+ cells. How these differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::097f7f9677884eec529ab211ea56cfe5
https://doi.org/10.1038/s41590-023-01469-2
https://doi.org/10.1038/s41590-023-01469-2
Autor:
Miho Shinzawa, E. Ashley Moseman, Selamawit Gossa, Yasuko Mano, Abhisek Bhattacharya, Terry Guinter, Amala Alag, Xiongfong Chen, Maggie Cam, Dorian B. McGavern, Batu Erman, Alfred Singer
Publikováno v:
Nature immunology. 23(5)
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains uncertain. We now report that switching cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b541b368a1ccee9612aed581f1a9d510
https://pubmed.ncbi.nlm.nih.gov/35804242
https://pubmed.ncbi.nlm.nih.gov/35804242
Autor:
Jan Wisniewski, Terry I. Guinter, John H. Kehrl, Yuan Zhuang, Tejas Kadakia, Xuguang Tai, Il-Young Hwang, Michael J. Kruhlak, Sumedha Roy, Alfred Singer, Amala Alag
Publikováno v:
The Journal of Experimental Medicine
The E-protein transcription factors E2A and HEB regulate thymocyte expression of the chemokine receptor CXCR4 to retain preselection thymocytes in the thymic cortex. TCR-mediated positive selection signals extinguish CXCR4 expression to allow positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18238610a4b69c2bf4a418683423806
https://doi.org/10.1084/jem.20182285
https://doi.org/10.1084/jem.20182285