Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alfred SL Cheng"'
Autor:
Jinglin, Zhang, Bonan, Chen, Hui, Li, Yifei, Wang, Xiaoli, Liu, Kit Yee, Wong, Wai Nok, Chan, Aden Ky, Chan, Alvin Hk, Cheung, Kam Tong, Leung, Yujuan, Dong, Yi, Pan, Huixing, Ke, Li, Liang, Zhaocai, Zhou, Jianyong, Xiao, Chi Chun, Wong, William Kk, Wu, Alfred Sl, Cheng, Brigette By, Ma, Jun, Yu, Kwok Wai, Lo, Wei, Kang
Publikováno v:
The Journal of Pathology. 259:205-219
Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment exerts crucial effects in driving CRC progression. Cancer-associated fibroblasts (CAFs) serve as one of the most important tumor microenvironment componen
Autor:
Wei Kang, Qin Cao, Otto Kw. Cheung, Stephen L. Chan, Liangliang Xu, Myth T.S. Mok, Alfred Sl Cheng, Feng Wu, Paul B.S. Lai, Yalin Tu, Kevin Y. Yip, Ka F. To, Joseph J.Y. Sung, Patrick Tan, Lemuel Lm. Szeto, Weiqin Yang
Publikováno v:
Cancer Letters. 525:115-130
Hepatocellular carcinoma (HCC) is a major cancer burden worldwide with increasing incidence in many developed countries. Super-enhancers (SEs) drive gene expressions required for cell type-specificity and tumor cell identity. However, their roles in
Autor:
Zhixian Liang, Jianquan Cao, Wenshu Tang, Haoran Wu, Yalin Tu, Zhewen Xiong, Jingying Zhou, Stephen L Chan, Alfred SL Cheng
Publikováno v:
Basic Hepatology.
Autor:
Anthony Wh Chan, Alfred Sl Cheng, Candice Ch Lam, Vincent W-S Wong, Alice P. Kong, Wenshu Tang, Weiqin Yang, Jingying Zhou, Heung Man Lee, S. K. H. Wong, Yu Feng
Publikováno v:
Abstracts.
Background Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer deaths worldwide. Driven by the epidemics of obesity and diabetes, it is anticipated that non-alcoholic fatty liver disease (NAFLD) wi
Autor:
Jiawei, Chen, Isabella Wai-Yin, Cheuk, Man-Ting, Siu, Weiqin, Yang, Alfred Sl, Cheng, Vivian Yvonne, Shin, Ava, Kwong
Publikováno v:
Am J Cancer Res
Cellular metabolism reprogramming is a hallmark in cancers including breast cancer. Switching off the glycolytic energy in cancer has been indicated as one of the anti-cancer strategies. Aberrant haptoglobin (HP) expression has been shown to cause me
Autor:
Ka Fai To, Anthony Wh Chan, Stephen L. Chan, Otto Kw. Cheung, Kevin Yl Yip, Jingying Zhou, Alfred Sl Cheng, Weiqin Yang, Hanyong Sun, Yu Feng, Joseph J.Y. Sung, Zhiwei Chen
Publikováno v:
Basic Hepatology.
Background The heterogeneous responses to immune-checkpoint blockade (ICB) therapy e.g. anti-programmed death-ligand 1 (PD-L1) antibody are attributable to the complex interplay between a range of cancer-cell-autonomous cues and immunosuppressive tum
Publikováno v:
Basic Hepatology.
Background and objective Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer deaths worldwide. Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of disorders from simple steatosis to n
Autor:
Yangchao Chen, Chi‐Han Li, Ka Fai To, Xiangdong Fang, Alfred Sl Cheng, Zhangang Xiao, Joanna Hung Man Tong
Publikováno v:
International Journal of Cancer. 140:120-129
MicroRNA-34a (miR-34a) is frequently downregulated in pancreatic ductal adenocarcinoma (PDAC) cells, however, the silencing mechanism remains unclear. Enhancer of zeste homolog 2 (EZH2) is overexpressed in PDAC, and our previous miRNA profiling showe
Autor:
Wei Kang, Jun Yu, Junhong Zhao, Joanna Hm Tong, Enders Kw Ng, Minnie Y. Go, Ka Fai To, Joseph J.Y. Sung, Yujuan Dong, P.W.Y. Chiu, Alfred Sl Cheng
Publikováno v:
Oncoscience
BACKGROUND Helicobacter pylori (H. pylori) is the most important gastric carcinogen. However, the mechanisms of H. pylori induced gastric carcinogenesis through STAT3 activation are largely unknown. We evaluated the effects of H. pylori infection on
Publikováno v:
The Journal of pathology. 239(3)
Epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodelling and microRNAs, convert environmental signals to transcriptional outputs but are commonly hijacked by pathogenic microorganisms. Recent advances in cancer e