Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Alfred Ross"'
Publikováno v:
CHIMIA, Vol 61, Iss 10 (2007)
Externí odkaz:
https://doaj.org/article/9020971bf4084d13887c34c1c1690ea7
Autor:
Eric-André Kusznir, Jean-Christophe Hau, Michaela Portmann, Anne-Gaëlle Reinhart, Fabio Falivene, Jessica Bastien, Jesper Worm, Alfred Ross, Matthias Lauer, Philippe Ringler, Filippo Sladojevich, Sylwia Huber, Konrad Bleicher, Michael Keller
Publikováno v:
Bioconjugate Chemistry. 34:866-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b442ab932caa92dc32e3a2f57bf189a
https://doi.org/10.1021/acs.bioconjchem.3c00085
https://doi.org/10.1021/acs.bioconjchem.3c00085
Autor:
Katja Heinig, Filippo Sladojevich, Jeannine Petrig Schaffland, Georg Jaeschke, Alfred Ross, Philipp Koldewey, Saša M. Miladinović, Jin Wang, Caroline Rynn
Publikováno v:
Pharmaceutical Research. 39:653-667
Exploration of the chemical, analytical and pharmacokinetic properties of the API, RO7304898, an allosteric EGFR inhibitor, intended to be developed as a mixture of two rapidly interconverting diastereoisomers with composition ratio of approximately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73e622a7a6ab994ee6fe51bf457a35
https://doi.org/10.1007/s11095-022-03234-w
https://doi.org/10.1007/s11095-022-03234-w
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
Viscosity behavior of liquid oligonucleotide therapeutics and its dependence on formulation properties has been poorly studied to date. We observed a high increase in viscosity and solidification of therapeutic oligonucleotide formulations with incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395af238044d0797438557ca172451a5
https://pubmed.ncbi.nlm.nih.gov/36435312
https://pubmed.ncbi.nlm.nih.gov/36435312
Autor:
Gabriel Hoffmann, Nuria Sancho Oltra, Bernd Steinhuber, Wei Chen, Robert Kopf, Alfred Ross, Satya Krishna Kishore Ravuri, Christian Bell, Steven Bond
Publikováno v:
Journal of chromatography. A. 1652
Poloxamer 188 (P188) is formulated in proteinaceous therapeutics as an alternative surfactant to polysorbate because of its good chemical stability and surfactant properties, which enable interfacial protection, preventing visible and sub-visible par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509727901751d04606ad894c9fcfc6d5
https://pubmed.ncbi.nlm.nih.gov/34237484
https://pubmed.ncbi.nlm.nih.gov/34237484
Publikováno v:
Molecular Pharmaceutics. 14:284-295
The parallel artificial membrane permeability assay (PAMPA) has emerged as a widely used primary in vitro screen for passive permeability of potential drug candidates. However, the molecular structure of the permeation barrier (consisting of a filter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fae0f042b6d26f586ae6717560cb82e
https://doi.org/10.1021/acs.molpharmaceut.6b00889
https://doi.org/10.1021/acs.molpharmaceut.6b00889
Autor:
Peter Schmieder, Ryan M. Evans, Robert G. Brinson, Chad W. Lawrence, Kristian Schweimer, Yves Aubin, Ping Xu, Göran Widmalm, Andreas Blomgren, Hamish G. Grant, Anthony J. Kearsley, John P. Marino, Janez Plavec, John B. Jordan, Geneviève Gingras, Scott A. Bradley, Koichi Kato, Stuart Parnham, Patrick N. Reardon, John R. Cort, David W. Keizer, Edward R. Zartler, Feng Ni, Frank Delaglio, Gregor Ilc, Saeko Yanaka, David A. Keire, Jonas Ståhle, Mats Wikström, Luke W. Arbogast, Alfred Ross, Thea Suter-Stahel, Darón I. Freedberg, Ana Carolina de Mattos Zeri, Maurício L. Sforça, Nils Trieloff, Desiree Tsao, Torgny Rundlöf, Xinying Jia, Kang Chen, Ken Skidmore, Gregory K. Pierens, Houman Ghasriani, Donna M. Baldisseri, Carlos A. Amezcua, Mehdi Mobli, Julie Yu Wei, Christina M. Szabo, Gerhard Wider
Publikováno v:
mAbs
The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new analytical techniques that can precisely assess physicochemical properties of these large and very complex drugs for the pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f183bde956423f5930af0c3d9a27c283
https://nrc-publications.canada.ca/eng/view/object/?id=633c08c1-47ae-47b0-a883-a615bb5663ce
https://nrc-publications.canada.ca/eng/view/object/?id=633c08c1-47ae-47b0-a883-a615bb5663ce
Autor:
Dominique Burger, Guillaume A. Schoch, Toon Laeremans, David C. Fry, Ashwani Sharma, Jörg Benz, Michel O. Steinmetz, Ralf Thoma, Armin Ruf, Jan Steyaert, Alfred Ross, Thomas Kremer, Paola Di Lello, Hugues Matile, Maja Debulpaep, Arne C. Rufer, Walter Huber, Brigitte D'Arcy, Martine Stihle, Markus G. Rudolph
Publikováno v:
Journal of Biological Chemistry
Doublecortin is a microtubule-associated protein produced during neurogenesis. The protein stabilizes microtubules and stimulates their polymerization, which allows migration of immature neurons to their designated location in the brain. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01273fc3e700d1dafe66ffca88566d5
https://doi.org/10.1074/jbc.m116.726547
https://doi.org/10.1074/jbc.m116.726547
Autor:
Michael Müller, Matthias Höhne, Alfred Ross, Philipp Matzel, Dennis Wetzl, Hans Iding, Steven P. Hanlon, Beat Wirz, Hubertus Müller, Martin Gand
Publikováno v:
ChemCatChem. 8:2023-2026
Biocatalysis employing imine reductases is a promising approach for the one-step generation of chiral amines from ketones. The enzymes reported for this process suffer from low activity and moderate stereoselectivity. We identified a set of enzymes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08d20fcb677e8af43cd5ec0ba9ba21f
https://doi.org/10.1002/cctc.201600384
https://doi.org/10.1002/cctc.201600384
Publikováno v:
Pharmaceutical Research. 32:3201-3212
Antimicrobial preservatives are known to interact with proteins and potentially affect their stability in aqueous solutions. In this systematic study, the interactions of a model peptide with three commonly used preservatives, benzyl alcohol, phenol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c2df63bc2c1f6cafbc4b471b0b3b0e
https://doi.org/10.1007/s11095-015-1697-z
https://doi.org/10.1007/s11095-015-1697-z