Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alfred R. Crosswell"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1965-1970
Four polyamides based on the structure of spermine and spermidine were prepared and tested in vitro in an HL-60 cell differentiation assay. Their activity was compared with that of hexamethylene bisacetamide (HMBA) 1 whose optimal activity (ca. 65% d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c04b9e47e7b75b6ebaf45626b5bce2e2
https://doi.org/10.1016/s0960-894x(01)80996-3
https://doi.org/10.1016/s0960-894x(01)80996-3
Autor:
Alfred R. Crosswell, Karen Leboulluec, Saulnier Mark G, Danny P.C. McGee, Dolatrai M. Vyas, Byron H. Long
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1619-1624
The E-ring 3′,4′,5′-trihydroxy etoposide analog 3 of the clinical antitumor agent etoposide 1 was synthesized from the corresponding etoposide ortho-quinone 2 . This analog is twice as potent as etoposide in its ability to elicit topoisomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63d7810da1bb93d3408b71a434509e7
https://doi.org/10.1016/s0960-894x(00)80029-3
https://doi.org/10.1016/s0960-894x(00)80029-3
Autor:
Dolatrai M. Vyas, Jay O. Knipe, Henry Wong, Anna Maria Casazza, Terrence W. Doyle, Alfred R. Crosswell, Stephen W. Mamber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1357-1360
Synthesis and in vivo antitmor evaluation of water soluble 2′- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d61d1ce83eefcb8fa238933dea7ef0
https://doi.org/10.1016/s0960-894x(00)80348-0
https://doi.org/10.1016/s0960-894x(00)80348-0
Autor:
Alfred R. Crosswell, Byron H. Long, Saulnier Mark G, Karen L. LeBoulleuc, Dolatrai M. Vyas, Terrence W. Doyle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1213-1218
The E-ring 4′-deshydroxy-4′-methyl analogs of the clinical antitumor agents etoposide and teniposide were synthesized from the corresponding 4′-triflates. These compounds display significant antitumor activity against murine P388 leukemia in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a239d33d4687c6d9b175ea6f4e6f02e
https://doi.org/10.1016/s0960-894x(00)80216-4
https://doi.org/10.1016/s0960-894x(00)80216-4
Autor:
Terrence W. Doyle, John F. Kadow, Alfred R. Crosswell, William C. Rose, Dolatrai M. Vyas, Min Min Tun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:17-22
The A ring of the clinical antitumor agent, etoposide, was opened to a protected 6,7-diphenol which was derivatized to form a number of new analogs. These compounds displayed activity inferior to etoposide when evaluated against several tumor cells l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bdb79be1849c09864188c8cd38d1e94
https://doi.org/10.1016/s0960-894x(00)80646-0
https://doi.org/10.1016/s0960-894x(00)80646-0
Publikováno v:
Journal of Natural Products. 54:1607-1611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98d0f149c624f0143ff9c9e42f9a483c
https://doi.org/10.1021/np50078a018
https://doi.org/10.1021/np50078a018
Autor:
Anna Maria Casazza, Pamela A. Trail, George A. Basler, Alfred R. Crosswell, Saulnier Mark G, William C. Rose
Publikováno v:
Investigational New Drugs. 8:S25-S32
BMY-40481-30 is a new, water-soluble derivative and probable prodrug of etoposide characterized by the presence of a phosphate group in position 4′ of the E ring of the etoposide molecule. The compound was only weakly cytotoxic in vitro and, conseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e757bad3524eda5edc03350c98f63f3
https://doi.org/10.1007/bf00171981
https://doi.org/10.1007/bf00171981
Publikováno v:
JNCI Journal of the National Cancer Institute. 82:510-512
Phosphonylmethoxyalkylpurine analogues were evaluated for their antitumor activity in murine tumor models. Three compounds, (S)-9-[(3-hydroxy-2-phosphonylmethoxy)propyl]adenine (HPMPA), 9-[(2-phosphonylmethoxy)ethyl]adenine (PMEA), and 9-[(2-phosphon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba70266201550f69629d7193e5990a7
https://doi.org/10.1093/jnci/82.6.510
https://doi.org/10.1093/jnci/82.6.510
Publikováno v:
Toxicologic pathology. 22(5)
The effects of high toxic doses of the anticancer drugs, etoposide and its phosphate derivative, BMY-40481, on the nervous system of female CD-1 mice were examined by light microscopy (LM) and transmission electron microscopy. Mice were euthanatized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8d56122124108861491d96188c3c77
https://pubmed.ncbi.nlm.nih.gov/7899782
https://pubmed.ncbi.nlm.nih.gov/7899782
Autor:
and E. Meyers, Veeraswamy Manne, L. Dean, Stella Huang, Wen-Chih Liu, Dolores M. Pirnik, M. Bulgar, Junius M. Clark, Terrence W. Doyle, M. Barbacid, Alfred R. Crosswell, J. S. Wells, Prabhavathi B. Fernandes
Publikováno v:
Europe PubMed Central
10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of RAS p21 protein. The compound was isolated from the fermentation broth and its structure determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7dbd3f3322932247a337f6f21e19ac
https://pubmed.ncbi.nlm.nih.gov/1592677
https://pubmed.ncbi.nlm.nih.gov/1592677