Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alfred M. Del Vecchio"'
Autor:
Ronald B. Turner, Philip E. Silkoff, Patrick Branigan, Alfred M. Del Vecchio, Susan Flavin, Elliot S. Barnathan
Publikováno v:
Pulmonary Pharmacology & Therapeutics
There is an association with acute viral infection of the respiratory tract and exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Although these exacerbations are associated with several types of viruses, human rhinoviruses (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce434ad294ab2921624ce1ab6513e40f
https://doi.org/10.1016/j.pupt.2014.10.005
https://doi.org/10.1016/j.pupt.2014.10.005
Autor:
Christian Herzmann, Ronald B. Turner, Mathew J. Loza, Robert Gordon, René Lutter, Sebastian L. Johnston, David Proud, Frédéric Baribaud, Brian Lipworth, Dave Singh, Alfred M. Del Vecchio, Philip E. Silkoff, Elliot S. Barnathan, Andreas Eich, Peter J. Sterk, Zuzana Diamant, Tjeert T. Mensinga, Patrick Branigan, Vibeke Backer, Scott A. Halperin, James E. Gern, Susan Flavin, Lani San Mateo
Background Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma. Objective We sought to evaluate an inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d492722fb5f03a97012b0c9809d9a
http://hdl.handle.net/10044/1/51680
http://hdl.handle.net/10044/1/51680
Autor:
Olivia Goethals, Alfred M. Del Vecchio, Francois Nicol, Kurt Hertogs, Yuan Peng Zhang, Zheng Xu, Lester L. Gutshall, Tim Hugo Maria Jonckers, Reginald Clayton, Robert T. Sarisky, Asa Ohagen, Lieve Emma Jan Michiels, Sharon Bola, Haiyan Jiang, Marnix Van Loock, John Grigsby, Mark W. Cunningham
Publikováno v:
Antiviral Research. 84:142-149
Selective delivery of antiretrovirals to human immunodeficiency virus (HIV) infected cells may reduce toxicities associated with long-term highly active antiretroviral therapy (HAART), may improve therapeutic compliance and delay the emergence of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322a28309dc9f5a7dee0732ddbee8a3a
https://doi.org/10.1016/j.antiviral.2009.08.003
https://doi.org/10.1016/j.antiviral.2009.08.003
Publikováno v:
Journal of Neurovirology
Infection of mice with mouse hepatitis virus (MHV) strain JHM (RJHM) induces lethal encephalitis, with high macrophage and neutrophil, but minimal T-cell, infiltration into the brain when compared to the neuroattenuated strain RA59. To determine if c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3666cda33975bf4ff8daf47e4f3f296a
https://doi.org/10.1080/13550280701750635
https://doi.org/10.1080/13550280701750635
Autor:
J. Furze, Alfred M. Del Vecchio, Marian Kruszynski, Concepción Palomo, Eric J. Beil, Lester L. Gutshall, Nicole D. Day, Ping Tsui, Patrick Branigan, Changbao Liu, Geraldine Taylor, Sheng-Jiun Wu, José A. Melero, Albert Schmidt
Publikováno v:
Journal of General Virology. 88:2719-2723
Chimeric 101F (ch101F) is a mouse–human chimeric anti-human respiratory syncytial virus (HRSV) neutralizing antibody that recognizes residues within antigenic site IV, V, VI of the fusion (F) glycoprotein. The binding of ch101F to a series of pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd5bfbdbc04254ae0f4f2f9389c8b8d
https://doi.org/10.1099/vir.0.82753-0
https://doi.org/10.1099/vir.0.82753-0
Autor:
Mark Cunningham, Alfred M. Del Vecchio, Changbao Liu, Anuk Das, Joseph Vennarini, William G. Glass, Ken Dixon, Juliane Mills
Publikováno v:
Cytokine. 38:145-150
Biologic activities of IL-16 have been well described (e.g., chemotaxis of CD4+ cells, CD25 upregulation, secretion of IL-1b, IL-4 and TNF-a secretion) but very few signaling events have been described. To gain a better understanding of how the biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dfadbe0f92eb014874c3a44eff23d3
https://doi.org/10.1016/j.cyto.2007.05.016
https://doi.org/10.1016/j.cyto.2007.05.016
Autor:
John O'Connell, Huiming Cheng, Atul Agarwal, Alfred M. Del Vecchio, Rajiv Chopra, Anita Y. M. Howe, Steve Herrmann, Ian J. Thompson, Srinivas K. Chunduru
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:4103-4113
A new pyranoindole class of small-molecule inhibitors was studied to understand viral resistance and elucidate the mechanism of inhibition in hepatitis C virus (HCV) replication. HCV replicon variants less susceptible to inhibition by the pyranoindol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6fef80b382d7bedb511eb6db373ea
https://doi.org/10.1128/aac.00365-06
https://doi.org/10.1128/aac.00365-06
Autor:
Lester L. Gutshall, Patrick Branigan, José A. Melero, Changbao Liu, Alfred M. Del Vecchio, Robert T. Sarisky, Nicole D. Day
Publikováno v:
Journal of General Virology. 87:395-398
The cytoplasmic domains of the fusion proteins encoded by several viruses play a role in cell fusion and contain sites for palmitoylation associated with viral protein trafficking and virus assembly. The fusion (F) protein ofHuman respiratory syncyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10723d5d2f8b2eb4dc8e7f03edafe203
https://doi.org/10.1099/vir.0.81481-0
https://doi.org/10.1099/vir.0.81481-0
Autor:
Srinivas K. Chunduru, John W. Ellingboe, Huiming Cheng, Boris Feld, John O'Connell, Carl J. Baldick, Matthew W. Olson, Ian J. Thompson, Tarek S. Mansour, Michelle L. Kimberland, Marja van Zeijl, Girija Krisnamurthy, Christopher A. Benetatos, Joel S. Christensen, Dorothy C. Young, Ariamala Gopalsamy, Mark Orlowski, Steve Swanberg, Glen A. Coburn, Megan Thorn, Alfred M. Del Vecchio, Johnathan Bloom, Xiaoqun Jiang, S V Johann, Janis Upeslacis, Marc S. Collett, William P. Gorczyca, Anita Y. M. Howe, Steve Herrmann
Publikováno v:
Antimicrobial Agents and Chemotherapy
A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1 R )-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3750639fe4a595b533d24806055005
https://doi.org/10.1128/aac.48.12.4813-4821.2004
https://doi.org/10.1128/aac.48.12.4813-4821.2004
Autor:
Changbao Liu, Juili Lin-Goerke, Lester L. Gutshall, Baohua Gu, Alfred M. Del Vecchio, Cynthia A. Feltenberger, Derrick Maley
Publikováno v:
Journal of Virology. 74:1794-1800
Helicase/nucleoside triphosphatase (NTPase) motifs have been identified in many RNA virus genomes. Similarly, all the members of the Flaviviridae family contain conserved helicase/NTPase motifs in their homologous NS3 proteins. Although this suggests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906dc0a0f375ac04e55b9d95e15206df
https://doi.org/10.1128/jvi.74.4.1794-1800.2000
https://doi.org/10.1128/jvi.74.4.1794-1800.2000