Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Alfred L. M. Bothwell"'
Autor:
Olivia C. Ihedioha, Haley Q. Marcarian, Anutr Sivakoses, Stephen M. Beverley, Diane McMahon-Pratt, Alfred L. M. Bothwell
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundHost-related factors highly regulate the increased circulation of neutrophils during Leishmania infection. Platelet-derived Dickkopf-1 (DKK1) is established as a high-affinity ligand to LRP6. Recently, we demonstrated that DKK1 upregulates
Externí odkaz:
https://doaj.org/article/55f928ce26a24a75b624a2873a7d0b5d
Autor:
Olivia C. Ihedioha, Anutr Sivakoses, Stephen M. Beverley, Diane McMahon-Pratt, Alfred L. M. Bothwell
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPlatelets are rapidly deployed to infection sites and respond to pathogenic molecules via pattern recognition receptors (TLR, NLRP). Dickkopf1 (DKK1) is a quintessential Wnt antagonist produced by a variety of cell types including platelets
Externí odkaz:
https://doaj.org/article/bba3b1ba911e48cc9971cbc868bd1b68
Autor:
Wook-Jin Chae, Alfred L. M. Bothwell
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Regulatory T cells (Tregs) are an important subset of adaptive immune cells and control immune reactions for maintaining homeostasis. Tregs are generated upon their encounter with self or non-self-antigen and mediate tolerance or suppress aberrant im
Externí odkaz:
https://doaj.org/article/4c275ec1347f4421bf6d75733be8b4a3
Autor:
Wook-Jin Chae, Alfred L. M. Bothwell
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
The control of inflammatory diseases requires functional regulatory T cells (Tregs) with significant Gata-3 expression. Here we address the inhibitory role of Tregs on intestinal tumorigenesis in the Apc/Min+ mouse model that resembles human familial
Externí odkaz:
https://doaj.org/article/5361bde397c440b485773cb2e0000c43
Publikováno v:
J Leukoc Biol
The human body encounters various challenges. Tissue repair and regeneration processes are augmented after tissue injury to reinstate tissue homeostasis. The Wnt pathway plays a crucial role in tissue repair since it induces target genes required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfd57d018059731b707eeb04a500026
https://doi.org/10.1002/jlb.3ri0721-385r
https://doi.org/10.1002/jlb.3ri0721-385r
Publikováno v:
Developmental Neurobiology. 81:389-399
Zika virus (ZIKV) can generate a number of neurological dysfunctions in infected humans. Here, we tested the potential of human immune cells to protect against ZIKV infection in genetically humanized MISTRG mice. FACS analysis showed robust reconstit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8efddc7f06742e61cc4c53e95867de
https://doi.org/10.1002/dneu.22820
https://doi.org/10.1002/dneu.22820
Autor:
Tania Rahim, Madison A. Levinson, Kelly E. W. Carufe, Matthew Burak, Rithy Meas, Stephen Maher, Alfred L. M. Bothwell, Naomi Gades, Joann B. Sweasy
Publikováno v:
PLOS ONE, 17(4):e0267913
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3379f97f9308b145c354e2603d0cce9b
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267913#sec014
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267913#sec014
Autor:
Stephen E. Maher, Jaekwang Jeong, Jae Hun Shin, Alfred L. M. Bothwell, Jaechul Lim, Heon-Woo Lee
Publikováno v:
Proc Natl Acad Sci U S A
Cancer cells can develop an immunosuppressive tumor microenvironment to control tumor-infiltrating lymphocytes. The underlying mechanisms still remain unclear. Here, we report that mouse and human colon cancer cells acquire lymphocyte membrane protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbf33c96b2850186da8d677f62d5d6a
https://doi.org/10.1073/pnas.2110241118
https://doi.org/10.1073/pnas.2110241118
Autor:
Tania Rahim, R. Stephen Lloyd, Joann B. Sweasy, Melis Kant, Alireza G. Senejani, Madison Levinson, Stephen E. Maher, Miral Dizdaroglu, Caroline J. Zeiss, Rithy Meas, Marina Cardó-Vila, Sesha L. A. Paluri, Kaylyn Clairmont, Michael Kashgarian, Isabel Alvarado-Cruz, Pawel Jaruga, Alfred L. M. Bothwell, Erdem Coskun, Matthew J. Burak
Publikováno v:
DNA Repair (Amst)
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity and fidelity, and is also deficient in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ed4da1a3471381db99c441029e0b4f
https://pubmed.ncbi.nlm.nih.gov/34186496
https://pubmed.ncbi.nlm.nih.gov/34186496
Autor:
Jung Ho Kim, Yong Beom Park, Alfred L. M. Bothwell, Sankar Ghosh, Jae Seung Moon, Chin Hee Mun, Chun Chang Ho, Sung Dong Park, Sang Kyou Lee, Jin Su Shin, Sang Won Lee, Tae Yoon Park, Jen Young Cho
Publikováno v:
Kidney International. 93:1118-1130
Excessive expression of Tbet and IFNγ is evidence of systemic lupus erythematosus (SLE) in lupus patients. In this study, the nucleus-transducible form of Transcription Modulation Domain (TMD) of Tbet (ntTbet-TMD), which is a fusion protein between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7be4081abf7d58b5a1e430a55f1818
https://doi.org/10.1016/j.kint.2017.11.017
https://doi.org/10.1016/j.kint.2017.11.017