Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alfred L, Williams"'
Autor:
Seoyeon Bok, Dong Yeon Shin, Alisha R. Yallowitz, Mark Eiseman, Michelle Cung, Ren Xu, Na Li, Jun Sun, Alfred L. Williams, John E. Scott, Bing Su, Jae-Hyuck Shim, Matthew B. Greenblatt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Neurofibromatosis type I (NF1) is characterized by prominent skeletal abnormalities mediated in part by aberrant ERK pathway activation due to NF1 loss-of-function. Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation
Externí odkaz:
https://doaj.org/article/1bdc5e8883dd407b82aab19c4cfb975b
Autor:
Valentine R. St. Hilaire, William E. Hopkins, Yenteeo S. Miller, Srinivasa R. Dandepally, Alfred L. Williams
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 72-78 (2019)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines
Externí odkaz:
https://doaj.org/article/e47bc779dd024d47b625b58bbd5df528
Autor:
Stephen T.C. Wong, Li-An Yeh, John E. Scott, Hong Zhao, Alexandria T. Phan, Alfred L. Williams, Syed Ahmad, Xiaoping Zhu, Timothy Liu, Ren Kong
PDF file - 506KB, Supp. Fig. S1 2D structures of Amoxapine, Amoxapine's metabolites, Loxapine, and the previous reported potent GUS inhibitors - Inhibitor 1 and 2. Suppl. Fig. S2 The initial structures (left panel, Before MD) and the last snapshots (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a225afd9a133bef2e1e79e54383b80
https://doi.org/10.1158/1078-0432.22454507
https://doi.org/10.1158/1078-0432.22454507
Autor:
Stephen T.C. Wong, Li-An Yeh, John E. Scott, Hong Zhao, Alexandria T. Phan, Alfred L. Williams, Syed Ahmad, Xiaoping Zhu, Timothy Liu, Ren Kong
Purpose: Irinotecan (CPT-11) induced diarrhea occurs frequently in patients with cancer and limits its usage. Bacteria β-glucuronidase (GUS) enzymes in intestines convert the nontoxic metabolite of CPT-11, SN-38G, to toxic SN-38, and finally lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92418d4a91128658e5adf62c7b2a8f9a
https://doi.org/10.1158/1078-0432.c.6522764.v1
https://doi.org/10.1158/1078-0432.c.6522764.v1
Autor:
Alfred L. Williams, Smritee Pokharel, Gordon C. Ibeanu, Srinivasa R. Dandepally, Nailya S. Gliyazova
Publikováno v:
Exp Ther Med
Reactive oxygen species (ROS) play a central role in oxidative stress-associated neuronal cell death during ischemia. Further investigation into the inhibition of excessive ROS generation post-stroke is urgently required for the treatment of ischemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15591efe17e2a293a6179136ae535310
https://europepmc.org/articles/PMC8688931/
https://europepmc.org/articles/PMC8688931/
Autor:
Alfred L. Williams, William E Hopkins, Yenteeo S Miller, Valentine R. St. Hilaire, Srinivasa R. Dandepally
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 72-78 (2019)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6850e82e12ddfa02e22fdc50d138133
https://doi.org/10.3762/bjoc.15.8
https://doi.org/10.3762/bjoc.15.8
Autor:
Mark Eiseman, Matthew B. Greenblatt, Jae-Hyuck Shim, Jun Sun, Alisha R. Yallowitz, Dong Yeon Shin, Na Li, Michelle Cung, Bing Su, Seoyeon Bok, Ren Xu, Alfred L. Williams, John E. Scott
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Neurofibromatosis type I (NF1) is characterized by prominent skeletal manifestations caused by NF1 loss. While inhibitors of the ERK activating kinases MEK1/2 are promising as a means to treat NF1, the broad blockade of the ERK pathway produced by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f24f190ae8316acceb682d204a810
http://europepmc.org/articles/PMC7658220
http://europepmc.org/articles/PMC7658220
Autor:
Syed Ahmad, Valentine R. St. Hilaire, Gary L. Johnson, Srinivasa R. Dandepally, Alfred L. Williams, John E. Scott
Publikováno v:
Biochemical and Biophysical Research Communications. 496:205-211
The kinase MEKK2 (MAP3K2) activates the MEK5/ERK5 cell signaling pathway and may play an important role in tumor growth and metastasis. Thus, MEKK2 may represent a novel kinase target for cancer. In order to identify inhibitors of MEKK2, we screened
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2c5f2b0736238f8568e07025a255e1
https://doi.org/10.1016/j.bbrc.2018.01.027
https://doi.org/10.1016/j.bbrc.2018.01.027
Publikováno v:
Tetrahedron. 73:6712-6717
Starting from 3-methoxy N -acylpyrazinium salts, a new approach towards the synthesis of the antischistosomal drug praziquantel (PZQ) has been developed. Utilization of a palladium-catalyzed intramolecular Heck reaction to form dehydro-PZQ followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182ca95082c51c54aac896d3e6be1c0d
https://doi.org/10.1016/j.tet.2017.10.006
https://doi.org/10.1016/j.tet.2017.10.006
Autor:
Valentine R, St Hilaire, William E, Hopkins, Yenteeo S, Miller, Srinivasa R, Dandepally, Alfred L, Williams
Publikováno v:
Beilstein Journal of Organic Chemistry
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21bf4e0e02f82fd1aa50e2152a255c4e
https://pubmed.ncbi.nlm.nih.gov/30680041
https://pubmed.ncbi.nlm.nih.gov/30680041