Zobrazeno 1 - 10
of 7 413
pro vyhledávání: '"Alfred H."'
Autor:
Alfred H. Makura, Davison Zireva
Publikováno v:
Frontiers in Education, Vol 9 (2024)
Our paper explores the online learning experiences of two female students living with albinism in South Africa and Zimbabwe during the COVID-19 era. Using a two-case qualitative research design, we conducted in-depth face to face interviews with the
Externí odkaz:
https://doaj.org/article/2a6447fe631e4d2bb437f279041e4839
Autor:
Jamie Rijmers, Irene A. Retmana, Viët Bui, Davinia Arguedas, Maria C. Lebre, Rolf W. Sparidans, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116720- (2024)
Opnurasib (JDQ443) is a newly developed oral KRASG12C inhibitor, with a binding mechanism distinct from the registered KRASG12C inhibitors sotorasib and adagrasib. Phase I and II clinical trials for opnurasib in NSCLC are ongoing. We evaluated the ph
Externí odkaz:
https://doaj.org/article/aee126997e694d2fb3116e085d0ab755
Autor:
Wenlong Li, Rolf W. Sparidans, Yaogeng Wang, Margarida L.F. Martins, Dirk R. de Waart, Olaf van Tellingen, Ji-Ying Song, Maria C. Lebre, Stéphanie van Hoppe, Els Wagenaar, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116644- (2024)
Transmembrane drug transporters can be important determinants of the pharmacokinetics, efficacy, and safety profiles of drugs. To investigate the potential cooperative and/or counteracting interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and
Externí odkaz:
https://doaj.org/article/397facf01d244b2c89255b44205a2de9
Autor:
Felix R. M. Koenig, Alfred H. Kielburg, Snehansh Roy Chaudhary, Christian Wassipaul, Akash Ganguly, Raoul Varga, Martin L. Watzenboeck, Iris-Melanie Noebauer-Huhmann
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1640 (2024)
Background: Early detection of soft tissue sarcoma (STS) recurrence is essential; however, the role and timeline of Magnetic resonance imaging (MRI) surveillance are still under debate. The aim of this study was to determine whether local recurrence
Externí odkaz:
https://doaj.org/article/d813aeab02114fcfb74ceda4923d4e4d
Autor:
Alfred H. Mazorodze, Peter Mkhize
Publikováno v:
South African Journal of Information Management, Vol 26, Iss 1, Pp e1-e6 (2024)
Background: In a competition for scarce resources, higher education institutions in developing countries have lost to other priorities. The article examines specific barriers to innovation in the higher education context. A thorough understanding and
Externí odkaz:
https://doaj.org/article/c32e53249772436ebcb622490a5ac42d
Autor:
David Damoiseaux, Alfred H. Schinkel, Jos H. Beijnen, Alwin D. R. Huitema, Thomas P. C. Dorlo
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract First‐in‐human dose predictions are primarily based on no‐observed‐adverse‐effect levels in animal studies. Predictions from these animal models are only as effective as their ability to predict human results. To narrow the gap bet
Externí odkaz:
https://doaj.org/article/4492d5c59a174fd3b85d7757ccdc1918
Autor:
Changpei Gan, Jing Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Els Wagenaar, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Sjoerd Klarenbeek, Rahmen Bin Ali, Colin Pritchard, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 618-631 (2023)
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout
Externí odkaz:
https://doaj.org/article/87e193186c58427c9b561d417264b90f
Autor:
Nancy H.C. Loos, Irene A. Retmana, Jamie Rijmers, Yaogeng Wang, Changpei Gan, Maria C. Lebre, Rolf W. Sparidans, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115304- (2023)
Adagrasib (Krazati™) is the second FDA-approved specific KRASG12C inhibitor for non-small cell lung cancer (NSCLC) patients harboring this mutation. The impact of the drug efflux transporters ABCB1 and ABCG2, and the drug-metabolizing enzymes CYP3A
Externí odkaz:
https://doaj.org/article/d1dc8905ed1b43a4a3acf85b155c81d5
Autor:
Changpei Gan, Jing Wang, Yaogeng Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Maria C. Lebre, Els Wagenaar, Hilde Rosing, Sjoerd Klarenbeek, Onno B. Bleijerveld, Ji-Ying Song, Maarten Altelaar, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114956- (2023)
Mammalian carboxylesterase 1 enzymes can hydrolyze many xenobiotic chemicals and endogenous lipids. We here identified and characterized a mouse strain (FVB/NKI) in which three of the eight Ces1 genes were spontaneously deleted, removing Ces1c and Ce
Externí odkaz:
https://doaj.org/article/6feb859d901d4d4c97531a2a7f1a6338
Autor:
Bo Peng, Kara K. L. Reeves, Shara W. Y. Lee, Tina H. Y. Chung, Heidi W. L. Hui, Alfred H. L. Leung, Johnson C. Y. Pang
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionThe COVID-19 pandemic has impacted children and adolescents’ physical activity (PA), sleeping patterns, and psychological and behavioral health. Yet, little is known about the differences between those in countries with various economic
Externí odkaz:
https://doaj.org/article/5b8423a5d22c43adac5bfc418bf47191