Výsledky vyhledávání - "Alfred G. Knudson"

Akademický článek

Meta-analysis identifies NF-κB as a therapeutic target in renal cancer.

Autor: Suraj Peri, Karthik Devarajan, Dong-Hua Yang, Alfred G Knudson, Siddharth Balachandran

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76746 (2013)

OBJECTIVE:To determine the expression patterns of NF-κB regulators and target genes in clear cell renal cell carcinoma (ccRCC), their correlation with von Hippel Lindau (VHL) mutational status, and their association with survival outcomes. METHODS:M

Externí odkaz: https://doaj.org/article/7aa75c666b5346caaf6d3008e6454414

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Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation

Publikováno v: Oncotarget

// Suraj Peri 1 , Elena Caretti 2 , Rossella Tricarico 2 , Karthik Devarajan 1 , Mitchell Cheung 3 , Eleonora Sementino 3 , Craig W. Menges 3 , Emmanuelle Nicolas 3 , Lisa A. Vanderveer 4 , Sharon Howard 5 , Peggy Conrad 6 , James A. Crowell 7 , Kerr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3019690a2ab8180bf4a2b3044b29f657
https://pubmed.ncbi.nlm.nih.gov/27682873

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APC+/− alters colonic fibroblast proteome in FAP

Autor: Alfred G. Knudson, Harry S. Cooper, Yin A. He, Anthony T. Yeung, Steven H. Seeholzer, Renata A. Coudry, James A. Crowell, David Cheng, Bruce M. Boman, Sharon Howard, Levy Kopelovich, Elena L. Blagoi, Alfonso Bellacosa, Dawn M. Riddle, Emmanuelle Nicolas, Bhavinkumar B. Patel, Xin-Ming Li, Maketa P. Dixon, Peggy Conrad

Publikováno v: Oncotarget

Here we compared the proteomes of primary fibroblast cultures derived from morphologically normal colonic mucosa of familial adenomatous polyposis (FAP) patients with those obtained from unaffected controls. The expression signature of about 19% of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3231a779ec73123b30b956e1bc3ca500
http://europepmc.org/articles/PMC3195363

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Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations

Publikováno v: Cancer Prevention Research. 3:48-61

We hypothesized that cells bearing a single inherited “hit” in a tumor suppressor gene express an altered mRNA repertoire that may identify targets for measures that could delay or even prevent progression to carcinoma. We report here on the tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1199866c0684479ca91aa9acb8c151
https://doi.org/10.1158/1940-6207.capr-09-0078

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Revisiting tissue specificity of germline cancer predisposing mutations

Autor: John M. Maris, Alfred G. Knudson

Publikováno v: Nature reviews. Cancer. 15(2)

Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d24c53cbad32b5422527be2e3c93129
https://pubmed.ncbi.nlm.nih.gov/25688405

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Radiation dose-rate effects, endogenous DNA damage, and signaling resonance

Autor: Alfred G. Knudson, Michael M. Vilenchik

Publikováno v: Proceedings of the National Academy of Sciences. 103:17874-17879

We previously concluded, from our analysis of the published data of other investigators, that the yield of germ-line and somatic mutations after exposure to ionizing radiation is parabolically related to the logarithm of the dose-rate at which a give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8184f26db6ab8e91c8b88633f8659012
https://doi.org/10.1073/pnas.0607995103

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