Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alfred Chappell"'
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
Lijiang Shen, Patricia C. Giclas, Michael K. Pangburn, Alfred Chappell, Paul R. Reynolds, Ashley Frazer-Abel, Scott P. Henry, Husam Younis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:709-717
Differences in sensitivity of monkeys and humans to antisense oligonucleotide (ASO)-induced complement alternative pathway (AP) activation were evaluated in monkeys, humans, and in serum using biochemical assays. Transient AP activation was evident i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0364d32afaadda8615ec7a57d43b90
https://doi.org/10.1124/jpet.114.219378
https://doi.org/10.1124/jpet.114.219378
Autor:
Christian J. Leumann, Damian Ittig, Michaela Norrbom, Sue Murray, Thazha P. Prakash, Erich Koller, Andres Berdeja, Punit P. Seth, Alfred Chappell, Eric E. Swayze
Publikováno v:
Murray, Sue; Ittig, Damian; Koller, Erich; Berdeja, Andres; Chappell, Alfred; Prakash, Thazha P.; Norrbom, Michaela; Swayze, Eric E.; Leumann, Christian J.; Seth, Punit P. (2012). TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues-a comparative study of oligonucleotide length, design and chemistry. Nucleic acids research, 40(13), pp. 6135-6143. London: Oxford University Press 10.1093/nar/gks273
Nucleic Acids Research
Nucleic Acids Research
We report the evaluation of 20-, 18-, 16- and 14-mer phosphorothioate (PS)-modified tricycloDNA (tcDNA) gapmer antisense oligonucleotides (ASOs) in T(m), cell culture and animal experiments and compare them to their gap-matched 20-mer 2'-O-methoxyeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c92c0d56c63c1061e54f365f9315968
https://boris.unibe.ch/15321/1/6135.full-text-lowres.pdf
https://boris.unibe.ch/15321/1/6135.full-text-lowres.pdf
Autor:
S, Geary Richard, Z, Yu Rosie, Tanya, Watanabe, P, Henry Scott, E, Hardee Greg, Alfred, Chappell, John, Matson, Henri, Sasmor, Len, Cummins, A, Levin Arthur
Publikováno v:
Drug Metabolism and Disposition; November 2003, Vol. 31 Issue: 11 p1419-28, 10p