Výsledky vyhledávání - "Alfred C.O. Vertegaal"

Akademický článek

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

Autor: Stanislau Yatskevich, Jessie S. Kroonen, Claudio Alfieri, Thomas Tischer, Anna C. Howes, Linda Clijsters, Jing Yang, Ziguo Zhang, Kaige Yan, Alfred C.O. Vertegaal, David Barford

Publikováno v: Cell Reports, Vol 34, Iss 13, Pp 108929- (2021)

Summary: The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic s

Externí odkaz: https://doaj.org/article/a1a5997169cd4317ae112753474d9c07

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Akademický článek

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage

Autor: Ivo A. Hendriks, Louise W. Treffers, Matty Verlaan-de Vries, Jesper V. Olsen, Alfred C.O. Vertegaal

Publikováno v: Cell Reports, Vol 10, Iss 10, Pp 1778-1791 (2015)

Small ubiquitin-like modifiers play critical roles in the DNA damage response (DDR). To increase our understanding of SUMOylation in the mammalian DDR, we employed a quantitative proteomics approach in order to identify dynamically regulated SUMO-2 c

Externí odkaz: https://doaj.org/article/76262e78632e4256b82e0811d7073aa4

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Supplementary Figure S5 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Autor: Peter ten Dijke, John W.M. Martens, Long Zhang, Huib Ovaa, Alfred C.O. Vertegaal, Wilma E. Mesker, Hong-Jian Zhu, Roman I. Koning, Bob van de Water, Sylvia E. Le Dévédec, Xiaobing Zhang, Erik Bos, Maarten van Dinther, Prasanna Vasudevan Iyengar, Raymond Kooij, Paul P. Geurink, Mengdi Zhang, Román González-Prieto, Sijia Liu

Supplementary Figure S5. Related to Figure 4. A, Real-time scratch assay of MDA-MB-231 cells that are engineered to overexpressed TÎ²RI, SMAD2 or SMAD3 using the IncuCyte system. Western blot analysis of TÎ²RI, SMAD2 or SMAD3 expression levels in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b74107504bcf858548057c1e3198b4
https://doi.org/10.1158/1078-0432.22475499.v1

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Supplementary information from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Supplementary methods, supplementary table legends, supplementary references.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fcdf23ab272f9114560a33c87522d9
https://doi.org/10.1158/1078-0432.22475490

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Supplementary video from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Supplementary video

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9c5e141037872dc441511266fae518
https://doi.org/10.1158/1078-0432.22475484.v1

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Supplementary tables from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Supplementary Table S1-S6.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b51368d6fdcbb7f58a14982d237dce
https://doi.org/10.1158/1078-0432.22475487

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Data from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Purpose:Therapies directed to specific molecular targets are still unmet for patients with triple-negative breast cancer (TNBC). Deubiquitinases (DUB) are emerging drug targets. The identification of highly active DUBs in TNBC may lead to novel thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5895d340a42510193dd26a86d13a1e8
https://doi.org/10.1158/1078-0432.c.6529092.v1

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BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Autor: Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, Arnoud de Ru, Peter A. van Veelen, Pablo Huertas, Alfred C.O. Vertegaal, Román González-Prieto

SUMMARYDeficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway, and, together with BARD1, forms a heterodimer with ubiquitin E3 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d841fe6cc59bbe1b8537c7861f1d0d09
https://doi.org/10.1101/2023.01.12.523782

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Site-specific proteomic strategies to identify ubiquitin and SUMO modifications: Challenges and opportunities

Autor: Fredrik Trulsson, Alfred C.O. Vertegaal

Publikováno v: Seminars in Cell & Developmental Biology, 132, 97-108. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Seminars in Cell and Developmental Biology

Ubiquitin and SUMO modify thousands of substrates to regulate most cellular processes. System-wide identification of ubiquitin and SUMO substrates provides global understanding of their cellular functions. In this review, we discuss the biological im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aac6ca5fc673f671dced4f46972844c
http://hdl.handle.net/1887/3563907

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