Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Alfred Buck"'
Autor:
Simon J. Schreiner, Jiri M. G. Van Bergen, Anton F. Gietl, Alfred Buck, Christoph Hock, Klaas P. Pruessmann, Anke Henning, Paul G. Unschuld
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract Gamma‐hydroxy‐butyric acid (GABA) and glutamate are neurotransmitters with essential importance for cognitive processing. Here, we investigate relationships between GABA, glutamate, and brain ß‐amyloid (Aß) burden before clinical man
Externí odkaz:
https://doaj.org/article/5685ad73cd2641eba10e30c1dc8f0245
Autor:
Sonja M. Kagerer, Clemens Schroeder, Jiri M. G. van Bergen, Simon J. Schreiner, Rafael Meyer, Stefanie C. Steininger, Laetitia Vionnet, Anton F. Gietl, Valerie Treyer, Alfred Buck, Klaas P. Pruessmann, Christoph Hock, Paul G. Unschuld
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionHippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.MethodsData
Externí odkaz:
https://doaj.org/article/3e05d9bc1cb34efd91ea88ff605336e5
Autor:
Markus Jehl, Ekaterina Mikhaylova, Valerie Treyer, Marlena Hofbauer, Martin Hüllner, Philipp A. Kaufmann, Alfred Buck, Geoff Warnock, Viet Dao, Charalampos Tsoumpas, Daniel Deidda, Kris Thielemans, Max Ludwig Ahnen, Jannis Fischer
Publikováno v:
Journal of Imaging, Vol 9, Iss 1, p 2 (2022)
NeuroLF is a dedicated brain PET system with an octagonal prism shape housed in a scanner head that can be positioned around a patient’s head. Because it does not have MR or CT capabilities, attenuation correction based on an estimation of the atte
Externí odkaz:
https://doaj.org/article/cf58eebdc7404731ba4ba255f665a5e2
Autor:
Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock, Simon M. Ametamey
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-6 (2019)
Abstract Purpose (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising results in rodents and
Externí odkaz:
https://doaj.org/article/25e65f188ff04962924eeba6d01738bc
Autor:
Johannes Streffer, Valerie Treyer, Alfred Buck, Simon M. Ametamey, Milen Blagoev, Ralph P Maguire, Aurélie Gautier, Yves P. Auberson, Mark E. Schmidt, Ivan-Toma Vranesic, Baltazar Gomez-Mancilla, Fabrizio Gasparini
Publikováno v:
NeuroImage, Vol 230, Iss , Pp 117785- (2021)
Mavoglurant binds to same allosteric site on metabotropic glutamate receptor 5 (mGluR5) as [11C]-ABP688, a radioligand. This open-label, single-center pilot study estimates extent of occupancy of mGluR5 receptors following single oral doses of mavogl
Externí odkaz:
https://doaj.org/article/ade72d8efd5c49d88ff715c43ad5a8a3
Autor:
Valerie Treyer, Anton F. Gietl, Husam Suliman, Esmeralda Gruber, Rafael Meyer, Andreas Buchmann, Anass Johayem, Paul G. Unschuld, Roger M. Nitsch, Alfred Buck, Simon M. Ametamey, Christoph Hock
Publikováno v:
Brain and Behavior, Vol 10, Iss 6, Pp n/a-n/a (2020)
Abstract Introduction Metabotropic glutamate receptors play a critical role in the pathogenesis of Alzheimer's disease due to their involvement in processes of memory formation, neuroplasticity, and synaptotoxity. The objective of the current study w
Externí odkaz:
https://doaj.org/article/438971daf0114def963995fe9ad8c0ec
Autor:
Irene B. Meier, Patrick J. Lao, Anton Gietl, Robert S. Vorburger, José Gutierrez, Christopher M. Holland, Charles R.G. Guttmann, Dominik S. Meier, Alfred Buck, Roger M. Nitsch, Christoph Hock, Paul G. Unschuld, Adam M. Brickman
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 1, Iss , Pp 100001- (2020)
Background: The amyloid cascade hypothesis characterizes the stereotyped progression of pathological changes in Alzheimer's disease (AD) beginning with beta amyloid deposition, but does not address the reasons for amyloid deposition. Brain areas with
Externí odkaz:
https://doaj.org/article/fcc1603aeac24327962386aa041d5061
Autor:
Tetsuro Sekine, Alfred Buck, Gaspar Delso, Bradley Kemp, Edwin E G W Ter Voert, Martin Huellner, Patrick Veit-Haibach, Sandeep Kaushik, Florian Wiesinger, Geoffrey Warnock, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233886 (2020)
BACKGROUND:The purpose of this study was to assess the impact of vendor-provided atlas-based MRAC on FDG PET/MR for the evaluation of Alzheimer's disease (AD) by using simulated images. METHODS:We recruited 47 patients, from two institutions, who und
Externí odkaz:
https://doaj.org/article/515bfa284b1441a2b0d7d0f14e121359
Autor:
Frances C. Quevenco, Maria G. Preti, Jiri M. G. van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J. Schreiner, Stefanie C. Steininger, Rafael Meyer, Irene B. Meier, Adam M. Brickman, Sandra E. Leh, Anton F. Gietl, Alfred Buck, Roger M. Nitsch, Klaas P. Pruessmann, Peter C. M. van Zijl, Christoph Hock, Dimitri Van De Ville, Paul G. Unschuld
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-11 (2017)
Abstract Background The incidence of Alzheimer’s disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investigate the relationsh
Externí odkaz:
https://doaj.org/article/44703892075b44069f945e5a61cf174d
Autor:
Sebastian C Holst, Alexandra Sousek, Katharina Hefti, Sohrab Saberi-Moghadam, Alfred Buck, Simon M Ametamey, Milan Scheidegger, Paul Franken, Anke Henning, Erich Seifritz, Mehdi Tafti, Hans-Peter Landolt
Publikováno v:
eLife, Vol 6 (2017)
Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here demonstrate that metab
Externí odkaz:
https://doaj.org/article/827159348a494799a89ae5068a6fd19c