Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alfred, Tonelli"'
Autor:
Kathleen Van den Bulck, Siegrid Damsch, Gary Eichenbaum, Elaine Knight, Alfred Tonelli, L. Lammens, Bianca Feyen, Adriana Looszova, Kelley Michael F
Publikováno v:
Toxicologic Pathology. 39:337-347
In a three-week oral gavage toxicity study in rats, a high incidence of respiratory symptoms and high mortality was noted in compound-dosed rats only. Because of audible respiration, an effect in the upper respiratory tract was suspected and the nasa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeb0670f86d8562e44e032636d30290
https://doi.org/10.1177/0192623310388430
https://doi.org/10.1177/0192623310388430
Autor:
Gary Eichenbaum, Alfred Tonelli, V. Hillsamer, Kelley Michael F, Siegrid Damsch, K. Van den Bulck, Anton Megens, Elaine Knight, John Vandenberghe, Adriana Looszova, Karen Roels, L. Lammens, Bianca Feyen
Publikováno v:
Journal of Applied Toxicology. 31:342-354
Unscheduled mortality preceded by adverse respiratory clinical signs in rats dosed by oral gavage may not only be caused by technical gavage error or systemic toxicity but may also be caused by gastro-esophageal reflux and subsequent aspiration of hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ff8971b43cae218cee5942d7eda914
https://doi.org/10.1002/jat.1592
https://doi.org/10.1002/jat.1592
Autor:
Subrahmanyam Vangala, Alfred Tonelli
Publikováno v:
The AAPS Journal. 9:E284-E297
Application of “omics” technology during drug discovery and development is rapidly evolving. This review evaluates the current status and future role of “metabonomics” as a tool in the drug development process to reduce the safety-related att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8cf224d4f7be78434a6022aacb1376
https://doi.org/10.1208/aapsj0903031
https://doi.org/10.1208/aapsj0903031
Gavage-related reflux in rats: identification, pathogenesis, and toxicological implications (review)
Autor:
Anton Megens, Kathleen Van den Bulck, L. Lammens, Bianca Feyen, Kelley Michael F, Siegrid Damsch, John Vandenberghe, Elaine Knight, Gary Eichenbaum, Alfred Tonelli
Publikováno v:
Toxicologic pathology. 39(2)
After oral gavage dosing of rats, reflux may occur, resulting in serious respiratory effects and mortality. Published information on gavage-related reflux is limited, as it has not yet been a focus of research. Nevertheless, it represents a recurrent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df25fb5f42291659f18fcbdf201cc21
https://pubmed.ncbi.nlm.nih.gov/21422261
https://pubmed.ncbi.nlm.nih.gov/21422261
Autor:
Alfred Tonelli
Publikováno v:
Bioanalysis. 1(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a5cc086f9861e6e070ceee4420f911
https://pubmed.ncbi.nlm.nih.gov/21083127
https://pubmed.ncbi.nlm.nih.gov/21083127
Publikováno v:
Early Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b88d02aa35c678d2181997439e4006
https://doi.org/10.1002/9780470613191.ch8
https://doi.org/10.1002/9780470613191.ch8
Publikováno v:
Journal of clinical pharmacology. 50(4)
The FDA guidance on exploratory IND studies is intended to enable sponsors to move ahead more efficiently with the development of promising candidates. A survey of PhRMA member companies was conducted in 2007 to obtain a cross-sectional industry pers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6712e35efe5eb2f6115f7a663ad82ae4
https://pubmed.ncbi.nlm.nih.gov/20097935
https://pubmed.ncbi.nlm.nih.gov/20097935
Autor:
Judy S. Kelloway, Curtis A Johnson, Atanu Dutta, Robert Faulkner, Bruce E. Shapiro, Charles E. Halstenson, Stephen W Zimmerman, Douglas S Greene, Alfred Tonelli, John Haynes, Olatunde Kuye
Publikováno v:
Clinical Pharmacology and Therapeutics. 51:32-41
Tazobactam is an irreversible inhibitor of many beta-lactamases. In combination with piperacillin, tazobactam exhibits synergy against many beta-lactamase-producing bacteria. The pharmacokinetics of piperacillin and tazobactam were evaluated in eight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf83cf1c7fd83cde580af3cf860e80c
https://doi.org/10.1038/clpt.1992.5
https://doi.org/10.1038/clpt.1992.5
Publikováno v:
Drugs and the Pharmaceutical Sciences ISBN: 9781574448825
Preclinical Drug Development
Preclinical Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e608302e0dc2b2e93f926bd2f69d4c3
https://doi.org/10.1201/9780849360237.ch4
https://doi.org/10.1201/9780849360237.ch4
Autor:
Donna Donigi, Gale, Linda J, Landells, Domenico, Spina, Alan J, Miller, Kate, Smith, Terry, Nichols, Yakov, Rotshteyn, Alfred, Tonelli, Peter, Lacouture, Ronald M, Burch, Clive P, Page, Brian J, O'Connor
Publikováno v:
British journal of clinical pharmacology. 54(5)
To assess the pharmacokinetic and pharmacodynamic profile of the novel PDE4 inhibitor V11294A (3-(3-cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H purine hydrochloride) in healthy male volunteers.This was a double-blind, single dose, ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fab102809bea3937a5e59edc48d96ee3
https://pubmed.ncbi.nlm.nih.gov/12445026
https://pubmed.ncbi.nlm.nih.gov/12445026