Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Alfred, Sandrock"'
Autor:
Peter A. Calabresi, Ludwig Kappos, Gavin Giovannoni, Tatiana Plavina, Irene Koulinska, Michael R. Edwards, Bernd Kieseier, Carl deMoor, Elias S. Sotirchos, Elizabeth Fisher, Richard A. Rudick, Alfred Sandrock
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 11, Pp 2166-2173 (2021)
Abstract Objective To assess the independent contributions of clinical measures (relapses, Expanded Disability Status Scale [EDSS] scores, and neuroperformance measures) and nonclinical measures (new brain magnetic resonance imaging [MRI] activity an
Externí odkaz:
https://doaj.org/article/fa352fd8745148f48a725597ae0f7a77
Autor:
Ih Chang, Ludwig Kappos, Gavin Giovannoni, Peter A Calabresi, Alfred Sandrock, Wenting Cheng, Shan Xiao, Katherine Riester, Shibeshih Belachew, Aaron Deykin, Bing Zhu
Publikováno v:
Multiple Sclerosis Journal. 28:2263-2273
Background: Overall Disability Response Score (ODRS) is a composite endpoint including Expanded Disability Status Scale, Timed 25-foot Walk, and 9-Hole Peg Test, designed to quantify both disability improvement and worsening in multiple sclerosis (MS
Autor:
Ludwig Kappos, Michael R. Edwards, Peter A. Calabresi, Elizabeth Fisher, Irene Koulinska, Alfred Sandrock, Bernd C. Kieseier, Gavin Giovannoni, Tatiana Plavina, Carl de Moor, Richard A. Rudick, Elias S. Sotirchos
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 8, Iss 11, Pp 2166-2173 (2021)
Annals of Clinical and Translational Neurology, Vol 8, Iss 11, Pp 2166-2173 (2021)
Objective To assess the independent contributions of clinical measures (relapses, Expanded Disability Status Scale [EDSS] scores, and neuroperformance measures) and nonclinical measures (new brain magnetic resonance imaging [MRI] activity and serum n
Autor:
Catrinel Popescu, Anthony T. Reder, Maha Radhakrishnan, Aaron Berdofe, Anjali Nagpal, Karen Smirnakis, Rajani Rajbhandari, Maria L. Naylor, Arman Altincatal, Carl de Moor, Michelle Kim, Alfred Sandrock, Eunice Jung, Diego Centonze
Publikováno v:
CNS Drugs
Background Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and alter its clinical course. We assessed
Autor:
Edward D. Plowey, Thierry Bussiere, Raj Rajagovindan, Jennifer Sebalusky, Stefan Hamann, Christian von Hehn, Carmen Castrillo-Viguera, Alfred Sandrock, Samantha Budd Haeberlein, Christopher H. van Dyck, Anita Huttner
Publikováno v:
Acta neuropathologica. 144(1)
Amyloid beta (Aβ) plaque is a defining pathologic feature of Alzheimer disease (AD). Aducanumab, a monoclonal IgG1 that selectively binds aggregated species of Aβ, has been shown by amyloid positron emission tomography (Amyloid PET) to reduce Aβ p
Autor:
Robert C. Bucelli, Manjit McNeill, Shafeeq Ladha, Angela Genge, Stephanie Fradette, Ivan Nestorov, John Ravits, Philip Van Damme, Roger Lane, Christopher J McDermott, Jonathan Glass, Merit Cudkowicz, Laura Fanning, C. Frank Bennett, Heiko Runz, Ih Chang, Hani Houshyar, Toby A. Ferguson, Alfred Sandrock, Alan Pestronk, Danielle Graham, Timothy M. Miller, Randall G. Trudell, Nazem Atassi, Peter M. Andersen, François Salachas, Nicholas J. Maragakis, Albert L. Ludolph, Pamela J. Shaw, Lorne Zinman, Alexander McCampbell
Publikováno v:
New England Journal of Medicine. 383:109-119
Background Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administratio...
Autor:
Alfred Sandrock
Publikováno v:
Annals of neurology. 90(6)
Autor:
Nancy L. Kuntz, Julie A. Parsons, Russell J. Butterfield, Francy Shu, Sandra P. Reyna, Janbernd Kirschner, Sarah Gheuens, Marco Petrillo, Darryl C. De Vivo, Kathryn J. Swoboda, Christopher Stebbins, Wildon Farwell, Wuh-Liang Hwu, Haluk Topaloglu, Enrico Bertini, Kristina Johnson, Richard Foster, Douglas A. Kerr, Valeria A. Sansone, Monique M. Ryan, Tawfeg Ben-Omran, Stephanie Fradette, Ishir Bhan, Thomas O. Crawford, Richard S. Finkel, Alfred Sandrock, John F. Staropoli, Yuh-Jyh Jong, Gabriel Braley
Publikováno v:
Neuromuscular Disorders
Highlights • NURTURE is an ongoing study of nusinersen started in a presymptomatic stage of SMA. • All infants were ≥25 months old, and alive without permanent ventilation. • All infants achieved independent sitting and 88% (22/25) were walki
Autor:
Christian von Hehn, Spyros Chalkias, Laura Nisenbaum, Ying Zhu, Ivan Nestorov, Samantha Budd Haeberlein, Kumar Kandadi Muralidharan, LeAnne Skordos, Ying Tian, Katie Harrison, Shuang Wu, Craig Mallinckrodt, Tianle Chen, Raj Rajagovindan, Alfred Sandrock, Gersham Dent
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Revere P. Kinkel, Richard A. Rudick, Ray Su, Bob Engle, Carol Singh, Alfred Sandrock, Bernd C. Kieseier, Tatiana Plavina, Dipen Sangurdekar, Suzanne Szak, Carl de Moor, Elizabeth Fisher, Arie R Gafson, Jaya Goyal
Publikováno v:
JAMA Netw Open
IMPORTANCE: Data are needed on the potential long-term prognostic association of serum neurofilament light in multiple sclerosis (MS). OBJECTIVE: To evaluate serum neurofilament light as a biomarker associated with long-term disease outcomes in clini