Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alfonzo D. Jordan"'
Autor:
Daniel I. Rosenthal, Pauline J. Sanfilippo, Cheryl P. Kordik, Anil H. Vaidya, Barry Dubinsky, Alfonzo D. Jordan, Allen B. Reitz, Wu-Nan Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2381-2386
A series of pyrido[1,2- a ]benzimidazoles (PBIs) with substitution on the N 5 -nitrogen has been synthesized and found to possess high affinity for the benzodiazepine (BZD) site on the GABA-A receptor. The compounds evaluated include those bearing a
Publikováno v:
Expert Opinion on Therapeutic Patents. 6:1047-1060
The treatment of anxiety disorders remains an active area of research. Behavioural tests developed in the 1960s have been augmented by specific receptor binding assays. Selective modulation of these binding sites offers the hope that the abuse liabil
Autor:
Alan C. Gibbs, John A. Masucci, Bruce E. Maryanoff, Diane K. Luci, Marta C. Abad, Ioanna Petrounia, David F. McComsey, William J. Jones, John O’Neill, Stephen C. Yabut, Alfonzo D. Jordan
Publikováno v:
ACS medicinal chemistry letters. 2(7)
Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. We
Publikováno v:
The Journal of Organic Chemistry. 58:4979-4988
The Diels-Alder reactions of two dienes derived from carbohydrates and their carbocyclic analogs are described. The dienes (2S)-3,4-dihydro-2-methoxy-6-vinyl-2H-pyran (1) and (4R)-3,4-dihydro-4-methoxy-6-vinyl-2H-pyran (2) were synthesied from tri-O-
Autor:
Allen B. Reitz, Richard P. Shank, D. J. Bennett, M. J. Renzi, J. L. Vaught, Alfonzo D. Jordan, R. G. Sherrill, D. J. Wustrow, Mark E. McDonnell, Bruce E. Maryanoff, E. W. Baxter, Malcolm K. Scott, M. E. Ortegon, E. A. Malloy, E. E. Codd
Publikováno v:
ChemInform. 27
Autor:
Daniel I. Rosenthal, Alfonzo D. Jordan, Barry Dubinsky, Allen B. Reitz, Wu-Nan Wu, Pauline J. Sanfilippo, Cheryl P. Kordik, Anil H. Vaidya
Publikováno v:
ChemInform. 33
A series of pyrido[1,2- a ]benzimidazoles (PBIs) with substitution on the N 5 -nitrogen has been synthesized and found to possess high affinity for the benzodiazepine (BZD) site on the GABA-A receptor. The compounds evaluated include those bearing a
Autor:
Jennifer Kirkpatrick, Ed Lawson, Carsten Schubert, James K. Kranz, Dennis J. Hlasta, Jukka Kervinen, Alfonzo D. Jordan, Hongchung Ma, Lawrence Kuo, Bart DeCorte, Wenfeng Sun, Matthew J. Todd, Matthew Wayne Olson
Publikováno v:
The FASEB Journal. 23
Publikováno v:
The Journal of Organic Chemistry. 55:5761-5766
Variable-temperature 1 H NMR experiments on six N 6 -alkyladenines, additionally substituted at N 3 , N 7 , or N 9 , were conducted in DMSO-d 6 , CDCl 3 and D 2 O. Two distinct conformations (syn and anti) were observed for N 3 , N 6 -disubstituted a
Autor:
Yifang Huang, Chi Luo, Richard S. Alexander, Ellen W. Baxter, François Paul Bischoff, Robert E. Boyd, Douglas E. Brenneman, Stefan Masure, Didier Berthelot, Allen B. Reitz, Mirielle Braeken, Brett A. Tounge, Marc Mercken, Kelly A. Conway, Ludo Edmond Josephine Kennis, Charles H. Reynolds, Hans De Winter, Junya Qu, Wouter David Bruinzeel, Serge Maria Aloysius Pieters, Michael H. Parker, Alfonzo D. Jordan, Malcolm K. Scott
Publikováno v:
Journal of medicinal chemistry. 50(18)
A new aspartic protease inhibitory chemotype bearing a 2-amino-3,4-dihydroquinazoline ring was identified by high-throughput screening for the inhibition of BACE-1. X-ray crystallography revealed that the exocyclic amino group participated in a hydro
Publikováno v:
The Journal of organic chemistry. 68(22)
The reaction of molecular bromine (Br2) with arylthioureas is known to produce 2-aminobenzothiazoles (Hugerschoff reaction). We show here that benzyltrimethylammonium tribromide (1, PhCH2NMe3Br3), a stable, crystalline organic ammonium tribromide (OA