Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alfonso Schiavi"'
Autor:
Alfonso Schiavi, Claudia Cirotti, Lora-Sophie Gerber, Giulia Di Lauro, Silvia Maglioni, Priscila Yumi Tanaka Shibao, Sabrina Montresor, Janine Kirstein, Patrick Petzsch, Karl Köhrer, Roel P. F. Schins, Tina Wahle, Daniela Barilà, Natascia Ventura
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-22 (2023)
Abstract Alzheimer’s disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex biological process concurrently shaped by genetic, dietary and environmental factors
Externí odkaz:
https://doaj.org/article/b943984ede4d4379a2a87b1088dc502b
Autor:
Alfonso Schiavi, Eva Salveridou, Vanessa Brinkmann, Anjumara Shaik, Ralph Menzel, Sumana Kalyanasundaram, Ståle Nygård, Hilde Nilsen, Natascia Ventura
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106448- (2023)
Summary: Excessive iron accumulation or deficiency leads to a variety of pathologies in humans and developmental arrest in the nematode Caenorhabditis elegans. Instead, sub-lethal iron depletion extends C. elegans lifespan. Hypoxia preconditioning pr
Externí odkaz:
https://doaj.org/article/718e9a6fdb4d42a78172e8de69e26027
Autor:
Silvia Maglioni, Alfonso Schiavi, Marlen Melcher, Vanessa Brinkmann, Zhongrui Luo, Anna Laromaine, Nuno Raimundo, Joel N. Meyer, Felix Distelmaier, Natascia Ventura
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Mitochondrial deficiency causes rare incurable disorders. Here, the authors use C. elegans to study these diseases and find that the natural compound lutein prevents neurodevelopmental deficits, thus pointing to a possible therapeutic target for the
Externí odkaz:
https://doaj.org/article/58b5a0011c434f13b5493957dc295694
Autor:
Alfonso Schiavi, Alessandra Runci, Teresa Maiorino, Francesco Davide Naso, Marta Barenys, Ellen Fritsche, Flavie Strappazzon, Natascia Ventura
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Severe oxygen and iron deficiencies have evolutionarily conserved detrimental effects, leading to pathologies in mammals and developmental arrest as well as neuromuscular degeneration in the nematode Caenorhabditis elegans. Yet, similar to the benefi
Externí odkaz:
https://doaj.org/article/c752c67eeb67431790c27c68db397cc6
Autor:
Carmen Martínez-Fernández, Milana Bergamino, Alfonso Schiavi, David Brena, Natascia Ventura, Sebastian Honnen, Alberto Villanueva, Ernest Nadal, Julián Cerón
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used the nematode Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin. In this stu
Externí odkaz:
https://doaj.org/article/cdcb1c8b76c94909a5a92b8767d40b32
Autor:
Didac Carmona-Gutierrez, Andreas Zimmermann, Katharina Kainz, Federico Pietrocola, Guo Chen, Silvia Maglioni, Alfonso Schiavi, Jihoon Nah, Sara Mertel, Christine B. Beuschel, Francesca Castoldi, Valentina Sica, Gert Trausinger, Reingard Raml, Cornelia Sommer, Sabrina Schroeder, Sebastian J. Hofer, Maria A. Bauer, Tobias Pendl, Jelena Tadic, Christopher Dammbrueck, Zehan Hu, Christoph Ruckenstuhl, Tobias Eisenberg, Sylvere Durand, Noélie Bossut, Fanny Aprahamian, Mahmoud Abdellatif, Simon Sedej, David P. Enot, Heimo Wolinski, Jörn Dengjel, Oliver Kepp, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Junichi Sadoshima, Natascia Ventura, Stephan J. Sigrist, Guido Kroemer, Frank Madeo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple or
Externí odkaz:
https://doaj.org/article/5a077fc79ab04bd9a229474d374a66e5
Autor:
Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, Jennifer Kleinjohann, Alfonso Schiavi, Swantje Steinwachs, Charlotte Esser, Ralph Menzel, Sara Giani Tagliabue, Laura Bonati, Fiona Cox, Niloofar Ale-Agha, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Xavier Coumoul, Natascia Ventura
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 613 (2022)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how th
Externí odkaz:
https://doaj.org/article/fae757d48604452eaa2ef9ce87487b2d
Autor:
Silvia Maglioni, Nayna Arsalan, Anna Hamacher, Shiwa Afshar, Alfonso Schiavi, Mathias Beller, Natascia Ventura
Publikováno v:
Cells, Vol 11, Iss 1, p 100 (2021)
The aging process is concurrently shaped by genetic and extrinsic factors. In this work, we screened a small library of natural compounds, many of marine origin, to identify novel possible anti-aging interventions in Caenorhabditis elegans, a powerfu
Externí odkaz:
https://doaj.org/article/fd91548b434e4f5ea9ba58a8cf384c13
Autor:
Katja Merches, Alfonso Schiavi, Heike Weighardt, Swantje Steinwachs, Nadine Teichweyde, Irmgard Förster, Katrin Hochrath, Beatrix Schumak, Natascia Ventura, Patrick Petzsch, Karl Köhrer, Charlotte Esser
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2249 (2020)
Background Aryl hydrocarbon receptor (AHR)-deficient mice do not support the expansion of dendritic epidermal T cells (DETC), a resident immune cell population in the murine epidermis, which immigrates from the fetal thymus to the skin around birth.
Externí odkaz:
https://doaj.org/article/0f9be0f543554e1598a8094073e15b6d
Publikováno v:
Aging. 13:104-133
Genetic, dietary, and environmental factors concurrently shape the aging process. The aryl hydrocarbon receptor (AhR) was discovered as a dioxin-binding transcription factor involved in the metabolism of different environmental toxicants in vertebrat