Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Alfonso Rubio Navarro"'
Autor:
Maiko Matsui, Lauren E. Lynch, Isabella Distefano, Allison Galante, Aravind R. Gade, Hong-Gang Wang, Nicolas Gómez-Banoy, Patrick Towers, Daniel S. Sinden, Eric Q. Wei, Adam S. Barnett, Kenneth Johnson, Renan Lima, Alfonso Rubio-Navarro, Ang K. Li, Steven O. Marx, Timothy E. McGraw, Paul S. Thornton, Katherine W. Timothy, James C. Lo, Geoffrey S. Pitt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The canonical G406R mutation that increases Ca2+ influx through the CACNA1C-encoded CaV1.2 Ca2+ channel underlies the multisystem disorder Timothy syndrome (TS), characterized by life-threatening arrhythmias. Severe episodic hypoglycemia is
Externí odkaz:
https://doaj.org/article/c69ae191aabc414ca794e63e3df33805
Autor:
Melania Guerrero-Hue, Mercedes Vallejo-Mudarra, Cristina García-Caballero, Gina Marcela Córdoba-David, Alejandra Palomino-Antolín, Carmen Herencia, Beatriz Vendrell-Casana, Alfonso Rubio-Navarro, Jesús Egido, Luis Miguel Blanco-Colio, Juan Antonio Moreno
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115925- (2023)
Background: Rhabdomyolysis is a severe clinical syndrome associated to acute kidney injury (AKI) and chronic kidney disease (CKD). TWEAK/Fn14 signaling axis regulates renal inflammation and tubular cell death. However, the functional role of TWEAK/Fn
Externí odkaz:
https://doaj.org/article/a38a6f4bb8ce421fb7c661f8c5c2adac
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/f0582031a8414957bf5f905c129ba10f
Autor:
Jason Mighty, Alfonso Rubio-Navarro, Cui Shi, Jing Zhou, Miguel Flores-Bellver, Søren Heissel, Onyekwere Onwumere, Linda Einbond, Rajendra Gharbaran, Daniel S. Casper, Alberto Benito-Martin, Stephen Redenti
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
IntroductionDiabetic Retinopathy (DR) is a potentially blinding retinal disorder that develops through the pathogenesis of diabetes. The lack of disease predictors implies a poor prognosis with frequent irreversible retinal damage and vision loss. Ex
Externí odkaz:
https://doaj.org/article/b129fb42bb9a4132a2d3c9daef2b77e0
Autor:
Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, Lisa Stoll, Friederike Dündar, Alex M. Mawla, Lunkun Ma, Eric Cortada, Paul Zumbo, Ang Li, Moritz Reiterer, Nathalia Montoya-Oviedo, Edwin A. Homan, Norihiro Imai, Ankit Gilani, Chengyang Liu, Ali Naji, Boris Yang, Angie Chi Nok Chong, David E. Cohen, Shuibing Chen, Jingli Cao, Geoffrey S. Pitt, Mark O. Huising, Doron Betel, James C. Lo
Publikováno v:
Nature Cell Biology. 25:565-578
Autor:
Melania Guerrero-Hue, Alfonso Rubio-Navarro, Ángel Sevillano, Claudia Yuste, Eduardo Gutiérrez, Alejandra Palomino-Antolín, Elena Román, Manuel Praga, Jesús Egido, Juan Antonio Moreno
Publikováno v:
Nefrología, Vol 38, Iss 1, Pp 13-26 (2018)
La hemoglobina y la mioglobina son hemoproteínas que juegan un papel fundamental en el organismo ya que participan en el transporte de oxígeno. Sin embargo, debido a su estructura química, estas moléculas pueden ejercer efectos deletéreos cuando
Externí odkaz:
https://doaj.org/article/07ab050ab12f4b47accfcbbb65b2f559
Autor:
Melania Guerrero-Hue, Alfonso Rubio-Navarro, Ángel Sevillano, Claudia Yuste, Eduardo Gutiérrez, Alejandra Palomino-Antolín, Elena Román, Manuel Praga, Jesús Egido, Juan Antonio Moreno
Publikováno v:
Nefrología (English Edition), Vol 38, Iss 1, Pp 13-26 (2018)
Haemoglobin and myoglobin are haem proteins that play a key role as they help transport oxygen around the body. However, because of their chemical structure, these molecules can exert harmful effects when they are released massively into the bloodstr
Externí odkaz:
https://doaj.org/article/d0b8f204dfc844bf9f3ac017ea81710b
Autor:
Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Melania Guerrero-Hue, Cristina García-Caballero, Carmen Herencia, Eduardo Gutiérrez, Claudia Yuste, Ángel Sevillano, Manuel Praga, Javier Egea, Pablo Cannata, Isabel Cortegano, Belén de Andrés, María Luisa Gaspar, Susana Cadenas, Patrycja Michalska, Rafael León, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. We inv
Externí odkaz:
https://doaj.org/article/db9f163feba548e684515e2a31a59e8a
Autor:
Eric Cortada, Jun Yao, Yu Xia, Friederike Dündar, Paul Zumbo, Boris Yang, Alfonso Rubio-Navarro, Björn Perder, Miaoyan Qiu, Anthony M. Pettinato, Edwin A. Homan, Lisa Stoll, Doron Betel, Jingli Cao, James C. Lo
Publikováno v:
bioRxiv
The immune system coordinates the response to cardiac injury and is known to control regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade inflammation associated with heart failure. Here we profiled the inflammatory r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf17d632c7df2f261f3587e7610cbac
https://doi.org/10.1101/2023.03.15.532865
https://doi.org/10.1101/2023.03.15.532865
Autor:
Melania Guerrero-Hue, Sandra Rayego-Mateos, Cristina Vázquez-Carballo, Alejandra Palomino-Antolín, Cristina García-Caballero, Lucas Opazo-Rios, José Luis Morgado-Pascual, Carmen Herencia, Sebastián Mas, Alberto Ortiz, Alfonso Rubio-Navarro, Javier Egea, José Manuel Villalba, Jesús Egido, Juan Antonio Moreno
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 39 (2020)
Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or
Externí odkaz:
https://doaj.org/article/1b7bfe55885f4191b65646457b3e8d96