Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Alfonso M. Lechuga-Sancho"'
Autor:
María Heredia-Torrejón, Raúl Montañez, Antonio González-Meneses, Atilano Carcavilla, Miguel A. Medina, Alfonso M. Lechuga-Sancho
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract The diagnostic odysseys for rare disease patients are getting shorter as next-generation sequencing becomes more widespread. However, the complex genetic diversity and factors influencing expressivity continue to challenge accurate diagnosis
Externí odkaz:
https://doaj.org/article/e0e505386b544a9fa9b07c54af507670
Autor:
Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos, Alfonso M. Lechuga-Sancho
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no specific definition of
Externí odkaz:
https://doaj.org/article/e3183f1a486c44a6831df6b055916cf3
Autor:
Jesus Dominguez-Riscart, Nuria Buero-Fernandez, Ana Garcia-Zarzuela, Celia Morales-Perez, Ana Garcia-Ojanguren, Alfonso M. Lechuga-Sancho
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Type 1 diabetes (T1D) is a chronic condition, with increased morbidity and mortality, due to a higher rate of cardiovascular disease among other factors. Cardiovascular risk increases with the worse glycemic profile. Nutrition has a deep impact on di
Externí odkaz:
https://doaj.org/article/32455d93b01845a8bee325c095a540fc
Autor:
Jesus Dominguez-Riscart, Nuria Buero-Fernandez, Ana Garcia-Zarzuela, Fernando A. Marmolejo-Franco, Ana C. Perez-Guerrero, Alfonso M. Lechuga-Sancho
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
The goal in type 1 diabetes (T1D) therapy is to maintain optimal glycemic control under any circumstance. Diabetes technology is in continuous development to achieve this goal. The most advanced Food and Drug Administration- and European Medicines Ag
Externí odkaz:
https://doaj.org/article/7950cfe2bd7b4231be760adb682ac632
Autor:
José M. Palma, Rosa M. Mateos, Javier López-Jaramillo, Marta Rodríguez-Ruiz, Salvador González-Gordo, Alfonso M. Lechuga-Sancho, Francisco J. Corpas
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101525- (2020)
Catalase is a powerful antioxidant metalloenzyme located in peroxisomes which also plays a central role in signaling processes under physiological and adverse situations. Whereas animals contain a single catalase gene, in plants this enzyme is encode
Externí odkaz:
https://doaj.org/article/5f82f1484abc4c8ba716b656f1cf5806
Autor:
Antonia Diaz-Ganete, Aranzazu Quiroga-de-Castro, Rosa M. Mateos, Francisco Medina, Carmen Segundo, Alfonso M. Lechuga-Sancho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2559 (2021)
Basic research on types 1 and 2 diabetes mellitus require early stage studies using beta cells or cell lines, ideally of human origin and with preserved insulin secretion in response to glucose. The 1.1E7 cells are a hybrid cell line resulting from t
Externí odkaz:
https://doaj.org/article/d17a1028f71244b5bcb2897a20682855
Autor:
Álvaro González-Domínguez, Francisco Visiedo, Jesus Domínguez-Riscart, Beatriz Ruiz-Mateos, Ana Saez-Benito, Alfonso M. Lechuga-Sancho, Rosa María Mateos
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 244 (2021)
Childhood obesity, and specifically its metabolic complications, are related to deficient antioxidant capacity and oxidative stress. Erythrocytes are constantly exposed to multiple sources of oxidative stress; hence, they are equipped with powerful a
Externí odkaz:
https://doaj.org/article/a45555e2c19244e995a653677f49963e
Autor:
Celeste Santos-Rosendo, Fernando Bugatto, Alvaro González-Domínguez, Alfonso M. Lechuga-Sancho, Rosa Maria Mateos, Francisco Visiedo
Publikováno v:
Antioxidants, Vol 9, Iss 9, p 794 (2020)
Pregnancy-related disorders, including preeclampsia and gestational diabetes, are characterized by the presence of an adverse intrauterine milieu that may ultimately result in oxidative and nitrosative stress. This scenario may trigger uncontrolled p
Externí odkaz:
https://doaj.org/article/929ac7ac8c4848edbe02bc007a217e1f
Autor:
Elena Mendoza-Barberá, Josep Julve, Stefan K. Nilsson, Aivar Lookene, Jesús M. Martín-Campos, Rosa Roig, Alfonso M. Lechuga-Sancho, John H. Sloan, Pablo Fuentes-Prior, Francisco Blanco-Vaca
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 649-661 (2013)
During the diagnosis of three unrelated patients with severe hypertriglyceridemia, three APOA5 mutations [p.(Ser232_Leu235)del, p.Leu253Pro, and p.Asp332ValfsX4] were found without evidence of concomitant LPL, APOC2, or GPIHBP1 mutations. The molecul
Externí odkaz:
https://doaj.org/article/cc9ad1a45bfe42628d75543c29056fa3
Autor:
Antonia Diaz-Ganete, Gloria Baena-Nieto, Isabel M. Lomas-Romero, Jose Francisco Lopez-Acosta, Irene Cozar-Castellano, Francisco Medina, Carmen Segundo, Alfonso M. Lechuga-Sancho
Publikováno v:
International Journal of Endocrinology, Vol 2015 (2015)
Ghrelin is a peptidic hormone, which stimulates cell proliferation and inhibits apoptosis in several tissues, including pancreas. In preclinical stage of type 1 diabetes, proinflammatory cytokines generate a destructive environment for β-cells known
Externí odkaz:
https://doaj.org/article/780c03d93e1d4f6891dc1d4c843f89b8