Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Alfonso, Bellacosa"'
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-37 (2024)
Abstract AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a range of normal cellular physiologies that also underlie several pathological conditions, including inflammatory and autoimmune diseases, overgro
Externí odkaz:
https://doaj.org/article/2abffedc50794523b4958f6123a95c28
Autor:
Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, Stéphanie Le Gras, Isabelle Stoll, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Alfonso Bellacosa, Christian Bronner, Ali Hamiche
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination o
Externí odkaz:
https://doaj.org/article/5389b4aa773a4bfe8eefdf04a989867d
Publikováno v:
Journal of Molecular Pathology, Vol 2, Iss 4, Pp 281-295 (2021)
Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromer
Externí odkaz:
https://doaj.org/article/8bb04d890a5543f89a7e83203097a7e1
Autor:
Atsushi Onodera, Edahí González-Avalos, Chan-Wang Jerry Lio, Romain O. Georges, Alfonso Bellacosa, Toshinori Nakayama, Anjana Rao
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not reco
Externí odkaz:
https://doaj.org/article/22b84e20f85e4b3baaf5156ae16cde0f
Autor:
Michael Hamm, Pierre Sohier, Valérie Petit, Jérémy H. Raymond, Véronique Delmas, Madeleine Le Coz, Franck Gesbert, Colin Kenny, Zackie Aktary, Marie Pouteaux, Florian Rambow, Alain Sarasin, Nisamanee Charoenchon, Alfonso Bellacosa, Luis Sanchez-del-Campo, Laura Mosteo, Martin Lauss, Dies Meijer, Eirikur Steingrimsson, Göran B. Jönsson, Robert A. Cornell, Irwin Davidson, Colin R. Goding, Lionel Larue
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in th
Externí odkaz:
https://doaj.org/article/963d00b98bc54a4ea97659da7f5bc553
Autor:
Valeria Masciullo, Tommaso Susini, Giacomo Corrado, Marina Stepanova, Alessandro Baroni, Irene Renda, Francesca Castiglione, Corrado Minimo, Alfonso Bellacosa, Benito Chiofalo, Enrico Vizza, Giovanni Scambia
Publikováno v:
Diagnostics, Vol 12, Iss 10, p 2401 (2022)
Beta-catenin is involved in intercellular adhesion and participates in the Wnt signaling pathway. This study evaluated the expression pattern and prognostic value of β-catenin in a series of endometrial carcinoma patients. Immunohistochemical analys
Externí odkaz:
https://doaj.org/article/799d2b95cdbc4c1e9380283f27c28e5c
Publikováno v:
Advanced Genetics, Vol 2, Iss 1, Pp n/a-n/a (2021)
Abstract DNA methylation is a critical process in the regulation of gene expression with dramatic effects in development and continually expanding roles in oncogenesis. 5‐Methylcytosine was once considered to be an inherited and stably repressive e
Externí odkaz:
https://doaj.org/article/05953e231fae4ad6a9c8b1d9670bae1f
Autor:
Alfred G. Knudson, Levy Kopelovich, Eric Ross, Henry T. Lynch, James A. Crowell, Margie L. Clapper, Anthony T. Yeung, Emmanuelle Nicolas, Kerry S. Campbell, Sharon Howard, Mary Daly, Yan Zhou, Carolyn Slater, Betsy Bove, Lisa Vanderveer, Elena Caretti, Karthik Devarajan, Suraj Peri, Andrew K. Godwin, Alfonso Bellacosa
We hypothesized that cells bearing a single inherited “hit” in a tumor suppressor gene express an altered mRNA repertoire that may identify targets for measures that could delay or even prevent progression to carcinoma. We report here on the tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f028d0affc83af02d79b29ac06cda94
https://doi.org/10.1158/1940-6207.c.6544698.v1
https://doi.org/10.1158/1940-6207.c.6544698.v1
Autor:
Alfred G. Knudson, Levy Kopelovich, Eric Ross, Henry T. Lynch, James A. Crowell, Margie L. Clapper, Anthony T. Yeung, Emmanuelle Nicolas, Kerry S. Campbell, Sharon Howard, Mary Daly, Yan Zhou, Carolyn Slater, Betsy Bove, Lisa Vanderveer, Elena Caretti, Karthik Devarajan, Suraj Peri, Andrew K. Godwin, Alfonso Bellacosa
Perspective on this Article from Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321a5a3ec1c10e98ac9d026d8ac1cbdf
https://doi.org/10.1158/1940-6207.22525347
https://doi.org/10.1158/1940-6207.22525347
Autor:
Alfred G. Knudson, Levy Kopelovich, Eric Ross, Henry T. Lynch, James A. Crowell, Margie L. Clapper, Anthony T. Yeung, Emmanuelle Nicolas, Kerry S. Campbell, Sharon Howard, Mary Daly, Yan Zhou, Carolyn Slater, Betsy Bove, Lisa Vanderveer, Elena Caretti, Karthik Devarajan, Suraj Peri, Andrew K. Godwin, Alfonso Bellacosa
Supplementary Methods, Tables 1-3, Figure 1 from Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4002f5049475c5c1c10bf559d42b76f0
https://doi.org/10.1158/1940-6207.22525344
https://doi.org/10.1158/1940-6207.22525344