Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Alfons Verbruggen"'
Autor:
Maarten Ooms, Sofie Celen, Ronald De Hoogt, Ilse Lenaerts, Johnny Liebregts, Greet Vanhoof, Xavier Langlois, Andrey Postnov, Michel Koole, Alfons Verbruggen, Koen Van Laere, Guy Bormans
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 1, Iss 1, Pp 1-17 (2016)
Abstract Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JN
Externí odkaz:
https://doaj.org/article/d4dd4237d5784bcaae606d3049b031e4
Autor:
Junjie Li, Feng Chen, Yuanbo Feng, Marlein Miranda Cona, Jie Yu, Alfons Verbruggen, Jian Zhang, Raymond Oyen, Yicheng Ni
Publikováno v:
Translational Oncology, Vol 6, Iss 1, Pp 42-50 (2013)
OBJECTIVE: Differently located tumors of the same origin may exhibit diverse responses to the same therapeutics. To test this hypothesis, we compared the responses of rodent hepatic and subcutaneous engrafts of rhabdomyosarcoma-1 (R1) to a vascular d
Externí odkaz:
https://doaj.org/article/8d27742ce1a346029154537af41e8c31
Autor:
Muneer Ahamed, Daisy van Veghel, Christoph Ullmer, Koen van Laere, Alfons Verbruggen, Guy M Bormans
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Abstract The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification
Externí odkaz:
https://doaj.org/article/f9e6956787ab4c3d8a374e421b63d61c
Autor:
Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Early clinical results of two tau tracers, [ 18 F]T808 and [ 18 F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire compara
Externí odkaz:
https://doaj.org/article/614086a8936e4b7ebe4f365af2458065
Autor:
Matthias Bauwens, Marijke De Saint-Hubert, Jan Cleynhens, Laura Brams, Ellen Devos, Felix M Mottaghy, Alfons Verbruggen
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38428 (2012)
INTRODUCTION: In vivo pH imaging has been a field of interest for molecular imaging for many years. This is especially important for determining tumor acidity, an important driving force of tumor invasion and metastasis formation, but also in the pro
Externí odkaz:
https://doaj.org/article/0519488d8c9f4b6da0853fba4fce2275
Publikováno v:
Handbook of Radiopharmaceuticals
Autor:
Jan Cleynhens, Alfons Verbruggen
Publikováno v:
Reference Module in Biomedical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e656e996c6faf72acb36f4ef0347b2
https://doi.org/10.1016/b978-0-12-822960-6.00006-5
https://doi.org/10.1016/b978-0-12-822960-6.00006-5
Autor:
Uwe Himmelreich, Frederik Cleeren, Alfons Verbruggen, Wim Maes, Sarah Belderbos, Marlies Van de Wouwer, Michel Koole, Guy Bormans, Nick Geukens, Emilie M. F. Billaud
Publikováno v:
Bioconjugate Chemistry. 28:2915-2920
In cancer research, pretargeted positron emission tomography (PET) imaging has emerged as an effective two-step approach that combines the excellent target affinity and selectivity of antibodies with the advantages of using short-lived radionuclides
Autor:
José Ignacio Andrés, Michel Koole, Diederik Moechars, Katleen Fierens, Xavier Langlois, Frederik J. R. Rombouts, Koen Van Laere, Guy Bormans, Lieven Declercq, Jonas Mariën, Rik Vandenberghe, Thomas Tousseyn, Gregor James Macdonald, Wim Vanduffel, Mark E. Schmidt, Alfons Verbruggen
Publikováno v:
Journal of Nuclear Medicine. 58:975-981
In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥500×) in vitro selectivity for tau over β-amyloid, in comparison with the benchmark comp
Publikováno v:
ChemCatChem. 8:3692-3700
Carbon dioxide (CO2) as a synthon in organic transformations is very useful, especially when combined with transition metal catalysts. CO2 insertion on carbon(Aryl)-metal bonds are an elegant way to construct carbon-carbon bonds. A limited number of