Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Alfons G Hoekstra"'
Autor:
Nathalie van der Velde, Liping Wang, Joost G Daams, Mariska M G Leeflang, Eveline P van Poelgeest, Anouschka C Pronk, Alfons G Hoekstra
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction Cardiovascular disorders are increasingly recognised as important fall risk factors in older adults. Falls are a major public health problem in older adults, and therefore, effective interventions for reducing falls are essential for thi
Externí odkaz:
https://doaj.org/article/4d69883c410a4727a0c744e84a626309
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66138 (2013)
Treatment of stenosed coronary arteries by balloon angioplasty and stenting results in arterial injury including severe damage to the endothelium at the site of treatment and initiates a complex cascade of inflammatory processes that may lead to the
Externí odkaz:
https://doaj.org/article/db78ea2cdc904a59b55972a4c7c7cdc8
Autor:
Christian J. Spieker, Gábor Závodszky, Clarisse Mouriaux, Pierre H. Mangin, Alfons G. Hoekstra
To analyze flow conditions and cellular behavior at the onset of a hemostatic response in the injury of a microneedle-induced vessel puncture, a combinedin silicoandin vitroplatform is created. A cell-resolved blood flow model is utilized for in-dept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b474df4b8538735e8e8461ce142c89
https://doi.org/10.1101/2023.05.11.540363
https://doi.org/10.1101/2023.05.11.540363
Hemodynamics is crucial for the activation and aggregation of platelets in response to flow-induced shear. A novel image-based computational model that can accurately simulate blood flow through and around platelet aggregates is presented. The micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067416fb757ba86c33d93516a317de22
https://doi.org/10.1101/2023.02.22.529480
https://doi.org/10.1101/2023.02.22.529480
Autor:
Liping Wang, Anouschka C. Pronk, Eveline P. van Poelgeest, Robert Briggs, Jurgen A.H.R. Claassen, Sofie Jansen, Marjolein Klop, Frederik J. de Lange, Carel C.G.M. Meskers, Vincent J. J. Odekerken, Stephen J. Payne, Marijke C. Trappenburg, Roland D. Thijs, Jeroen F. Uleman, Alfons G. Hoekstra, Nathalie van der Velde
Publikováno v:
Geroscience. Springer International Publishing AG
GeroScience. Springer International Publishing AG
Wang, L, Pronk, A C, van Poelgeest, E P, Briggs, R, Claassen, J A H R, Jansen, S, Klop, M, de Lange, F J, Meskers, C C G M, Odekerken, V J J, Payne, S J, Trappenburg, M C, Thijs, R D, Uleman, J F, Hoekstra, A G & van der Velde, N 2023, ' Applying systems thinking to unravel the mechanisms underlying orthostatic hypotension related fall risk ', GeroScience . https://doi.org/10.1007/s11357-023-00802-9
GeroScience. Springer International Publishing AG
Wang, L, Pronk, A C, van Poelgeest, E P, Briggs, R, Claassen, J A H R, Jansen, S, Klop, M, de Lange, F J, Meskers, C C G M, Odekerken, V J J, Payne, S J, Trappenburg, M C, Thijs, R D, Uleman, J F, Hoekstra, A G & van der Velde, N 2023, ' Applying systems thinking to unravel the mechanisms underlying orthostatic hypotension related fall risk ', GeroScience . https://doi.org/10.1007/s11357-023-00802-9
Orthostatic hypotension (OH) is an established and common cardiovascular risk factor for falls. An in-depth understanding of the various interacting pathophysiological pathways contributing to OH-related falls is essential to guide improvements in di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d38129db272c8a8ffcf0e5d4a3d5320
https://pure.amc.nl/en/publications/applying-systems-thinking-to-unravel-the-mechanisms-underlying-orthostatic-hypotension-related-fall-risk(2cef388c-3871-4824-95ea-92456b2a00dc).html
https://pure.amc.nl/en/publications/applying-systems-thinking-to-unravel-the-mechanisms-underlying-orthostatic-hypotension-related-fall-risk(2cef388c-3871-4824-95ea-92456b2a00dc).html
Autor:
Raymond M. Padmos, Nerea Arrarte Terreros, Tamás I. Józsa, Gábor Závodszky, Henk A. Marquering, Charles B. L. M. Majoie, Stephen J. Payne, Alfons G. Hoekstra
Publikováno v:
Journal of the Royal Society, Interface, 19(195):20220649
Journal of the Royal Society, Interface / the Royal Society, 19(195):20220649. Royal Society of London
Journal of the Royal Society Interface, 19(195)
Padmos, R M, Arrarte Terreros, N, Józsa, T I, Závodszky, G B, Marquering, H A, Majoie, C B L M, Payne, S J & Hoekstra, A G 2022, ' Modelling collateral flow and thrombus permeability during acute ischaemic stroke ', Journal of the Royal Society, Interface, vol. 19, no. 195, 20220649, pp. 20220649 . https://doi.org/10.1098/rsif.2022.0649
Journal of the Royal Society, Interface / the Royal Society, 19(195):20220649. Royal Society of London
Journal of the Royal Society Interface, 19(195)
Padmos, R M, Arrarte Terreros, N, Józsa, T I, Závodszky, G B, Marquering, H A, Majoie, C B L M, Payne, S J & Hoekstra, A G 2022, ' Modelling collateral flow and thrombus permeability during acute ischaemic stroke ', Journal of the Royal Society, Interface, vol. 19, no. 195, 20220649, pp. 20220649 . https://doi.org/10.1098/rsif.2022.0649
The presence of collaterals and high thrombus permeability are associated with good functional outcomes after an acute ischaemic stroke. We aim to understand the combined effect of the collaterals and thrombus permeability on cerebral blood flow duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae68f87d176c01ecc07867a694c02b1
https://research.vumc.nl/en/publications/45425a47-c791-4f01-bf84-1b1d5e999001
https://research.vumc.nl/en/publications/45425a47-c791-4f01-bf84-1b1d5e999001
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, 10:18604. Nature Publishing Group
Scientific Reports
Scientific Reports, 10:18604. Nature Publishing Group
Scientific Reports
Occlusive thrombi formed under high flow shear rates develop very rapidly in arteries and may lead to myocardial infarction or stroke. Rapid platelet accumulation (RPA) and occlusion of platelet-rich thrombi and clot shrinkage have been studied after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0916b08b0191e9574dc8ae10aaad998c
http://link.springer.com/article/10.1038/s41598-020-74518-7
http://link.springer.com/article/10.1038/s41598-020-74518-7
Publikováno v:
Biophysical Journal, 119(3), 638-651. Biophysical Society
Biophys J
NARCIS
Microsoft Academic Graph
Biophysical Journal
Biophys J
NARCIS
Microsoft Academic Graph
Biophysical Journal
The fibrin clot is gelatinous matter formed upon injury to stop blood loss and is later destroyed by fibrinolysis, an enzymatic cascade with feedback. Pharmacological fibrinolysis stimulation is also used to destroy pathological, life-threatening clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4961cf4eb383960b18dd022f020bd129
https://doi.org/10.1016/j.bpj.2020.06.020
https://doi.org/10.1016/j.bpj.2020.06.020
Publikováno v:
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology, 19(2), 681-692. Springer Verlag
Biomechanics and Modeling in Mechanobiology, 19(2), 681-692. Springer Verlag
Endothelial cells (ECs) play a major role in the healing process following angioplasty to inhibit excessive neointima. This makes the process of EC healing after injury, in particular EC migration in a stented vessel, important for recovery of normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c0c94f761a636fb38fd1fb512ec9c7
https://doi.org/10.1007/s10237-019-01239-w
https://doi.org/10.1007/s10237-019-01239-w
Publikováno v:
International Journal for Uncertainty Quantification, 10(4), 333-349. Begell House Inc.
In order to accurately describe the mechanics of red blood cells (RBCs) and resulting fluid dynamics, a cell-resolved blood flow fluid solver is required. The parameters of the material model for the RBC membranes are carefully tuned to reproduce the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3c75bb05c338e2fa8bfe386fb0210b
https://doi.org/10.1615/int.j.uncertaintyquantification.2020033186
https://doi.org/10.1615/int.j.uncertaintyquantification.2020033186